1 | Introduction
The dermal extracellular matrix (ECM) serves as a scaffold composed of various proteins, with collagen being the predominant component that imparts durability and structural support to the skin. The structural and functional significance of collagen in the skin cannot be overstated. Collagen fibers, primarily type I and III, confer tensile strength and contribute to the maintenance of skin thickness and elasticity. The delicate balance between collagen synthesis and degradation is paramount for skin homeostasis, and disruptions in this equilibrium are implicated in various dermatological conditions, including premature aging, skin sagging, and impaired wound healing [1].
Collagen synthesis, degradation, and remodeling are meticulously regulated processes, with hormonal signals playing a pivotal role in modulating these intricate mechanisms. Among these hormones, estrogen, traditionally linked to reproductive functions, emerges as a key influencer of skin physiology with its multifaceted effects. The decline in estrogen levels, particularly during menopause, represents a significant reduction in skin health such as overall thinning, fine wrinkles, and
this article is excerpted from the Journal of Cosmetic Dermatology, 2025; 24:e16719 by Wound World.
