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Alfredo E. Hoyos，MDD；Mauricio E. Perez Pachon，MDD;
Matt Stefanelli，MD；Mariana Borras Osorio, MD； Justo Calderon
Mendoza，MSc；Maria Paula Castiblanco，MD；
Mateo Leon Machicado，MD；and Andres Pinzon Valero，MD
Abstract
Background: Despite the general safety of liposuction and fat grafting procedures，surgical-site infections (SSIs) remain a significant concern. These infections, ranging from minor to severe，can arise from various sources and pose a substantial burden. The overuse of antibiotics has led to increased antimicrobial resistance，highlighting the need for alternative infection prevention strategies like stabilized hypochlorous acid (s-HOCl). Objectives: The aim of the authors of this study is to evaluate the efficacy and safety of s-HOCl in preventing SSIs following liposculpture and other body contouring procedures. Methods: A prospective cohort study and matched control cohort were conducted at a single plastic surgery center in Bogota，Colombia (Dhara Clinic). Adult patients scheduled for liposculpture and fat grafting from January 2020 to December 2023 formed the intervention group，receiving s-HOCl as a washing solution for adipose grafts. A matched control cohort was drawn from patients who underwent similar procedures from January 2017 to December 2019 without s-HOCl. Data on demographics，surgical characteristics，and SSI outcomes were collected and analyzed. Results: A total of 1008 patients were included，with 502 in the s-HOCl group and 506 in the control group. The infection rate in the s-HOCl group was 0.2 per 100 grafted muscles, compared with 0.54 in the control group. Relative risk of SSIs in the s-HOCl group was 0.4，indicating a reduction in infection rates. The small absolute risk reduction of 0.59% underscores the clinical importance，considering SSIs, although rare，are severe and life-threatening events，with significant impact on outcomes and healthcare costs. A reduction in the severity of infection and the level of required treatment was also observed. Conclusions: s-HOCl demonstrated potential to reduce SSI risk following liposuction and fat grafting. This intervention offers a valuable alternative to antibiotics，effectively reducing infection rates and contributing to improved patient outcomes and public health in postantibiotic era.
王昳娜1，何振华1，周瑾1，孙晓芬2
1.绍兴文理学院元培学院，浙江 312000；2.浙江中医药大学附属第二医院
Research progress on the application of hypochlorous acid in wound care
WANG Yi'na，HE Zhenhua，ZHOU Jin，SUN Xiaofen
Shaoxing University，Yuanpei College，Zhejiang 312000 China
Keywords hypochlorous acid solution；wound；infection；bacterial biofilm；clinical application；review
摘要 介绍了次氯酸溶液的发展史、杀菌机制、特点、与其他伤口清洁消毒剂的比较、使用方法以及当前研究的不足，旨在为次氯酸
溶液在伤口治疗、护理中的应用提供依据。
关键词 次氯酸溶液；伤口；感染；细菌生物膜；临床应用；综述
杨金燕1，孙丹1，夏婷婷1，施施1，杨育卉2，闫中强1.3
1.解放军总医院海南医院疾病预防控制科2.血液科，海南 三亚 572014；3.解放军总医院第二医学中心疾病预防控制科，北京 100039
摘要:次氟酸消毒剂以其强大的消毒杀菌能力和环境友好特性，在医疗领域得到广泛关注及应用。有效浓度的次氟酸不仅能高效杀灭细菌、病毒等微生物,同时具有低毒、无残留、低腐蚀性等优势,适用于各种精密设备及复杂的医疗场景。次氯酸消毒剂可用于儿科病房、血液透析室等重点医疗场所的环境消毒。此外，在口腔护理、伤口处理、手术部位消毒等领域展现了独特的优势。本文探讨了次氯酸消毒剂的性能,为其在医疗机构的合理应用提供参考。随着清洁消毒技术的不断进步和应用的深入拓展，次氟酸消毒剂在医疗领域的应用前景将更加广阔。
关键词:次氯酸；次氯酸消毒剂；医疗机构；理化性质；临床消毒
中图分类号:R187 文献标识码:A 文章编号:1005-4529（2025）03-0476-05
Progress of research on clinical application of hypochlorous acid disinfectant
YANG Jinyan*，SUN Dan，XIA Tingting，SHI Shi，YANG Yuhui，YAN Zhongqiang* Hainan Hos pital of PLAGeneral Hospital，Sanya ，Hainan 572014，China
Abstract: Hypochlorous acid disinfectant has been widely noticed and applied in the medical field due to its power-ful disinfecting and sterilizing ability and environmental friendly characteristics.Effective concentration of hypo-chlorous acid disinfectant can not only efficiently kill bacteria,viruses and other microorganisms, but also has theadvantages of low toxicity,no residue and low corrosion，which is suitable for all kinds of complicated equipmentand complex medical scenarios,It can be used for environmental disinfection in major medical places such as pedi-atric wards and hemodialysis rooms,In addition,it demonstrates unique advantages in the oral care,wound treat-ment， and surgical site disinfection, This article explores the properties of hypochlorous acid disinfectant to pro-vide reference for the reasonable application in healthcare facilities,With the continuous progress of cleaning anddisinfection technology and ir-depth expansion of application,the prospect of hypochlorous acid disinfectant appli-cation in the medical field will be broader.
Key words:Hypochlorous acid;Hypochlorous acid disinfectant; Medical institution;Physicochemical property;Disinfection
