Xue Liu1 | Tamer-Whittle Hage1 | Li-Chi Chen2 | Eddy Hsi Chun Wang1 | I-Chien Liao1 | Jodi Goldberg1 | Sabina Gosto1 | Paula Cziryak1 | Maryanne Senna2 | Ying Chen1 | Qian Zheng1
1 L'Oreal Research and Innovation, Clark, New Jersey, USA | 2Harvard Medical School, Boston & Beth Israel Lahey Health, Burlington, Massachusetts, USA
Correspondence: Xue Liu (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)
Received: 14 May 2024 | Revised: 4 October 2024 | Accepted: 18 October 2024
Keywords: anti-inflammatory | antioxidant | barrier function
Jingyi Wang | Hu Huang | Kan Tao | Lili Guo | Xincheng Hu | Huailong Chang
Global R&D Center, Shanghai Chicmax Cosmetic Co. Ltd., Global Harbor Tower B, Shanghai, China
Correspondence
Huailong Chang, Global R&D Center, Shanghai Chicmax Cosmetic Co. Ltd., Global Harbor Tower B, 3300 North Zhongshan Road, Putuo District, Shanghai 200065, China.
Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Abstract
Background: Skin aging is one of the most abundant aging-related disorders that can be accelerated by excessive exposure to ultraviolet irradiation. Topically applied fermented skincare ingredients have gained mounting attentions due to their high concentration of various skin nourishing nutrients and bioactive components and low skin irritation potency.
Aims: In the present study, we aim to fully demonstrate the skin-related benefits of a novel extract of Thermus thermophilus and Bacillus subtilis mixed-culture ferment (TBFE).
Methods: TBFE was prepared through an innovative mixed-culture fermentation process. The contents of nutrients and bioactive ingredients were quantified by different methods accordingly. Both in vitro tests and randomized controlled human trial were utilized to further demonstrate multifaceted beneficial effects on human skin, as well as the potential mechanisms.
Results: Our results showed that TBFE upregulated the expression of type IV collagen, elastin, aquaporin-3, and dermal-epidermal junction markers, while inhibited production of melanin, in different skin cell models. Moreover, TBFE inhibited the generation of reactive oxygen species and pro-inflammatory mediators induced by ultraviolet irradiation in normal human keratinocytes, while stimulated autophagy in senescent keratinocytes. Results from clinical studies confirmed those in vitro findings, demonstrating that TBFE at 5% and 20% concentration provides anti-aging properties in subjects with sensitive skin, in terms of improving wrinkles, moisturization, and skin
Conclusions: In summary, we demonstrate that a novel mixed-culture ferment extract has promising anti-aging effects, which may be attributed to anti-oxidation, antiinflammation, and promotion of autophagy in skin cells.
KEYWORDS
anti-aging, anti-inflammation, anti-oxidation, autophagy, mixed-culture fermentation
在医学上,皮肤病是有关皮肤的疾病,是严重影响人民健康的常见病、多发病之一,如麻风、疥疮、真菌病、皮肤细菌感染等。皮肤病是皮肤(包括毛发和甲)受到内外因素的影响后,其形态、结构和功能均发生变化,产生病理过程,并相应的产生各种临床先后表现。皮肤病的发病率很高,多比较轻,常不影响健康,但少数较重甚至可以危及生命。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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