Matthew Simonson1 · Yanliang Li2 · J. Jason McAnany2 · Jason C. Park2 · Felix Y. Chau2 · Bharati Prasad3,4 · Silvana Pannain5 · Erin C. Hanlon5 · Eve Van Cauter5 · Kirstie K. Danielson6 · Brian T. Layden6 · Hui Chen7 · George E. Chlipala8 · Carlos Martinez8 · Stephanie J. Crowley9 · Sirimon Reutrakul6
Received: 23 August 2025 / Accepted: 23 February 2026 © The Author(s) 2026
Keywords Metabolomics · Diabetic retinopathy · Diabetes Mellitus · Retina
Communicated by Massimo Federici, M.D Matthew Simonson 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
1 College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA
2 Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Chicago, IL, USA
3 Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA
4 Jesse Brown Department of Veterans Affairs Hospital, Chicago, IL, USA
5 Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Chicago, Chicago, IL, USA
6 Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA
7 Mass Spectrometry Core, Research Resource Center, Office of Vice Chancellor for Research, University of Illinois at Chicago, Chicago, IL, USA
8 Research Informatics Core, Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA
9 Biological Rhythms Research Laboratory, Department of Psychiatry & Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
Xiaoyan Wang1 · Run Yang1 · Jingxiang Li1 · Yongqi Liang2 · Chenxi Jin1 · Yining Xu1 · Xianbo Wu2 · Mengchen Zou1
Received: 4 July 2025 / Accepted: 30 September 2025 / Published online: 15 October 2025 © The Author(s) 2025
Abstract
Background Excess weight is a progressive metabolic epidemic, and inflammation plays an important role in the progres-sion of disease. Insulin resistance (IR) is an important feature of obesity, but it does not reflect systemic inflammation. Cur-rently, there is a lack of effective clinical tools for early risk stratification and intervention in physically active people.
Methods This was a prospective cohort of 72,262 overweight but physically active persons in the UK Biobank. The TyG was combined with hsCRP, waist circumference (WC), or body mass index (BMI) as indices of IR. Adjusted Cox regression, interaction tests, restricted cubic splines (RCS) analysis, Kaplan-Meier analysis, and Harrell’s C-index were used to examine the relations and time-dependent predictive power.
Results During 12.7 years of follow-up, 1,477 participants developed metabolic dysfunction-associated fatty liver disease (MAFLD). RCS analysis suggested TyG-hsCRP had a nonlinear positive correlations with all-cause mortality. Compared to the lowest quartile group, the corrected hazard ratio (HR) (95% confidence interval [CI]) of new-onset MAFLD in maximum quartile groups for TyG-hsCRP was 1.94(1.62–2.32), for TyG-WC was 1.78(1.44–2.18), for TyG-BMI was 1.36(1.12–1.65), and for TyG was 1.41(1.15–1.72). The relation between C-index of TyG-hsCRP and MAFLD was higher than that of other TyG indices. Similar results were observed in all-cause mortality.
Conclusion TyG-hsCRP is superior to other indices for identifying risk of MAFLD and all-cause mortality in overweight but physically active people. Our findings suggest the importance of inflammatory metabolism and provide evidence for effectively early anti-inflammatory treatments.
Keywords Excess weight · Inflammation · Insulin resistance · Physically active
Communicated by Salvatore Corrao, M.D
Mengchen Zou
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Xianbo Wu
1 Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Road North, Guangzhou 510515, China
2 Department of Occupational Health and Medicine, School of Public Health, Southern Medical University, Guangzhou, China
在所有下肢溃疡中，静脉曲张性的溃疡占70%以上，静脉曲张性溃疡即下肢静脉曲张引起溃疡。
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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