Ademilton Costa Alves † , Sergio Murilo da Silva Braga Martins, Jr. † , José Victor Trindade Belo, Mauro Victor Castro Lemos , Carlos Emanuel de Matos Chaves Lima, Carlos Drielson da Silva, Adrielle Zagmignan and Luís Cláudio Nascimento da Silva *
Citation: Alves, A.C.; Martins, S.M.d.S.B., Jr.; Belo, J.V.T.; Lemos, M.V.C.; Lima, C.E.d.M.C.; Silva, C.D.d.; Zagmignan, A.; Nascimento da Silva, L.C. Global Trends and Scientific Impact of Topical Probiotics in Dermatological Treatment and Scientific Microorganisms 2024, 12, 2010. https://doi.org/10.3390/ microorganisms12102010 Academic Editor: Alex Galanis Received: 16 August 2024 Revised: 21 September 2024 Accepted: 24 September 2024 Published: 3 October 2024
Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)
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Abstract: The skin plays a crucial role in maintaining homeostasis and protecting against external ag gressors. Recent research has highlighted the potential of probiotics and postbiotics in dermatological treatments and skincare. These beneficial microorganisms interact with the skin microbiota, modulate the immune response, and enhance the skin barrier, offering a promising therapeutic avenue for various skin conditions, such as acne, dermatitis, eczema, and psoriasis. This bibliometric study aims to analyze the global trends and scientific impact of topical probiotics in dermatology. By reviewing 106 articles published between 2013 and 2023, the study categorizes the applications of probiotics in wound healing, inflammatory skin diseases, and general skincare. The findings indicate a sig nificant increase in publications from 2021 onwards, attributed to the heightened focus on medical research during the COVID-19 pandemic. This study also identifies the most productive countries, institutions, and authors in this field, highlighting the importance of international collaborations. The results underscore the efficacy of probiotic-based topical formulations in improving skin health, reducing inflammation, and enhancing wound healing. This comprehensive analysis supports the development of new therapeutic strategies based on topical probiotics and encourages high-quality research in this promising area.
Keywords: topical probiotics; skin microbiome; wound healing; inflammatory skin diseases; skin care
- Introduction
As the largest organ in the human body, the skin plays a multifaceted and crucial role in maintaining homeostasis. It serves as a vital physical barrier, regulating essential functions such as hydration, temperature control, and local immunity [1,2]. The skin shields the body from a variety of external aggressors, including pathogens, ultraviolet radiation, pollution, and harmful chemicals [3,4]. However, these environmental factors can promote the development of persistent skin disorders, such as dermatitis, acne, eczema, rosacea, psoriasis, wounds, and various infections. Such conditions can compromise the skin’s natural protective capabilities and adversely impact the quality of life for affected individuals [5,6]. Similar to the gastrointestinal tract, the skin harbors a complex community of mi croorganisms that interact with the host, protecting against pathogens, modulating the immune response, and preserving the skin barrier integrity [7,8]. The skin microbiome is a dynamic and complex ecosystem influenced by various factors, such as body region, age, gender, and geographic location. Common skin microbiota species include Staphylo coccus epidermidis, Cutibacterium acnes, and Corynebacterium species, each playing distinct
