伤口世界

电子邮件地址: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

星期四, 17 10月 2019

穿合适的鞋子，降低糖尿病足发生率！

原创：胡海涛负压引流与创面修复

糖尿病足病是糖尿病慢性并发症之一，治疗困难，医疗费用高，预后差，但预防很有效。国际糖尿病足工作组(IWGDF)2015年发布《糖尿病足预防指南》，旨在在世界范围内，贯彻糖尿病足预防为主的理念。

星期四, 17 10月 2019

严重糖足，报危急值的低钾、低钙，咋处理？

原创：胡海涛负压引流与创面修复

星期四, 17 10月 2019

这些漂亮的‘雨伞’，起源于长期口服通便药！

原创：胡海涛负压引流与创面修复

星期四, 17 10月 2019

27岁的胃癌，给我们的警示有哪些？

萤火虫医生负压引流与创面修复

星期四, 17 10月 2019

单位体检，能帮你发现早期肿瘤吗？

萤火虫医生负压引流与创面修复

临床所见——很多患者单位体检结果示‘身体健康状态良好’，几个月后却被确诊为‘癌症’。单位体检’未能发现存在的早期癌症，质疑当前的‘体检’意义，难道它是形式吗?

星期四, 17 10月 2019

长期服用泻药、养颜通便茶，会致癌，你知道吗？

萤火虫医生负压引流与创面修复

病例：

男性患者，77岁，退休教师，便秘多年，长期口服各类‘通便茶’，因‘消瘦半年’就诊，肠镜是结肠肿瘤、肠黑变病，病理示结肠腺癌，行腹腔镜手术+术后化疗。

K2 Content

Motor and vestibular signals in the visual cortex permit the separation of self versus externally generated visual motion 2025-07-04 00:00

Mateo Ve´ lez-Fort,1,3 Lee Cossell,1,3 Laura Porta,1 Claudia Clopath,1,2 and Troy W. Margrie1,4,*

1 Sainsbury Wellcome Centre, University College London, London, UK

2 Bioengineering Department, Imperial College London, London, UK

3 These authors contributed equally

4 Lead contact

*Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

https://doi.org/10.1016/j.cell.2025.01.032

SUMMARY

Knowing whether we are moving or something in the world is moving around us is possibly the most critical sensory discrimination we need to perform. How the brain and, in particular, the visual system solves this motion-source separation problem is not known. Here, we find that motor, vestibular, and visual motion signals are used by the mouse primary visual cortex (VISp) to differentially represent the same visual flow information according to whether the head is stationary or experiencing passive versus active translation. During locomotion, we find that running suppresses running-congruent translation input and that translation signals dominate VISp activity when running and translation speed become incongruent. This cross-modal interaction between the motor and vestibular systems was found throughout the cortex, indicating that running and translation signals provide a brain-wide egocentric reference frame for computing the internally generated and actual speed of self when moving through and sensing the external world.
Mapping the landscape of social behavior 2025-07-03 00:00

Ugne Klibaite,1,4,* Tianqing Li,2,4 Diego Aldarondo,1,3 Jumana F. Akoad,1 Bence P. O¨ lveczky,1,* and Timothy W. Dunn2,5,*

1 Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA

2 Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA

3 Present address: Fauna Robotics, New York, NY 10003, USA

4 These authors contributed equally

5 Lead contact

*Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (U.K.), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (B.P.O¨ .), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (T.W.D.)

https://doi.org/10.1016/j.cell.2025.01.044

SUMMARY

Social interaction is integral to animal behavior. However, lacking tools to describe it in quantitative and rigorous ways has limited our understanding of its structure, underlying principles, and the neuropsychiatric disorders, like autism, that perturb it. Here, we present a technique for high-resolution 3D tracking of postural dynamics and social touch in freely interacting animals, solving the challenging subject occlusion and partassignment problems using 3D geometric reasoning, graph neural networks, and semi-supervised learning. We collected over 110 million 3D pose samples in interacting rats and mice, including seven monogenic autism rat lines. Using a multi-scale embedding approach, we identified a rich landscape of stereotyped actions, interactions, synchrony, and body contacts. This high-resolution phenotyping revealed a spectrum of changes in autism models and in response to amphetamine not resolved by conventional measurements. Our framework and large library of interactions will facilitate studies of social behaviors and their neurobiological underpinnings.
Large language models deconstruct the clinical intuition behind diagnosing autism 2025-06-26 00:00

Jack Stanley,1,2,6 Emmett Rabot,3,4,6 Siva Reddy,1 Eugene Belilovsky,1,5 Laurent Mottron,3,4,7 and Danilo Bzdok1,2,7,8,*

1 Mila - Que´ bec Artificial Intelligence Institute, Montre´ al, QC H2S3H1, Canada

2 The Neuro - Montre´ al Neurological Institute (MNI), McConnell Brain Imaging Centre, Department of Biomedical Engineering, Faculty of Medicine, School of Computer Science, McGill University, Montre´ al, QC H3A2B4, Canada

3 Research Center, Centre Inte´ gre´ Universitaire de Sante´ et de Services Sociaux du Nord-de-lIle-de-Montre´ al (CIUSSS-NIM), Montre´ al, QC H4K1B3, Canada

4 Universite´ de Montre´ al, Montre´ al, QC H3C3J7, Canada

5 Department of Computer Science and Software Engineering, Concordia University, Montreal, QC H3G 1M8, Canada

6 These authors contributed equally

7 These authors contributed equally

8 Lead contact

*Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

https://doi.org/10.1016/j.cell.2025.02.025

SUMMARY

Efforts to use genome-wide assays or brain scans to diagnose autism have seen diminishing returns. Yet the clinical intuition of healthcare professionals, based on longstanding first-hand experience, remains the gold standard for diagnosis of autism. We leveraged deep learning to deconstruct and interrogate the logic of expert clinician intuition from clinical reports to inform our understanding of autism. After pre-training on hundreds of millions of general sentences, we finessed large language models (LLMs) on >4,000 free-form health records from healthcare professionals to distinguish confirmed versus suspected autism cases. By introducing an explainability strategy, our extended language model architecture could pin down the most salient single sentences in what drives clinical thinking toward correct diagnoses. Our framework flagged the most autism-critical DSM-5 criteria to be stereotyped repetitive behaviors, special interests, and perception-based behaviors, which challenges today,s focus on deficits in social interplay, suggesting necessary revision of long-trusted diagnostic criteria in gold-standard instruments.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

穿合适的鞋子，降低糖尿病足发生率！

严重糖足，报危急值的低钾、低钙，咋处理？

这些漂亮的‘雨伞’，起源于长期口服通便药！

27岁的胃癌，给我们的警示有哪些？

单位体检，能帮你发现早期肿瘤吗？

长期服用泻药、养颜通便茶，会致癌，你知道吗？

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

穿合适的鞋子，降低糖尿病足发生率！

严重糖足，报危急值的低钾、低钙，咋处理？

这些漂亮的‘雨伞’，起源于长期口服通便药！

27岁的胃癌，给我们的警示有哪些？

单位体检，能帮你发现早期肿瘤吗？

长期服用泻药、养颜通便茶，会致癌，你知道吗？

消息订阅

学术会议

伤口世界提示