Inhibition of polymicrobial biofilm formation by saw palmetto oil, lauric acid and myristic acid

Yong-Guy Kim† Jin-Hyung Lee† Sunyoung Park, Sanghun Kim and Jintae Lee * School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Korea.

Received 8 March, 2021; revised 22 May, 2021; accepted 23 May,*For correspondence. E-mail 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel. (+82) 53 810 2533; Fax (+82) 53 810 4631. †† Y.-G.K. and J.-H.L. contributed equally to this work. Microbial Biotechnology (2022) 15(2), 590–602

doi:10.1111/1751-7915.13864

Funding information

This research was supported by grants from the Basic Science Research Program through the NRF funded by the Ministry of Education (2021R1I1A3A04037486 to J.-H. Lee, 2019R1C1C1008329 to Y.-G. Kim), the NRF grant funded by the Korea government (MSIT) (No. 2021R1A2C1008368 to J. Lee), and by a grant from the Priority Research Centers Program through the NRF funded by the Ministry of Education (2014R1A6A1031189).

Summary

       Biofilms are communities of bacteria, fungi or yeasts that form on diverse biotic or abiotic surfaces, and play important roles in pathogenesis and drug resistance. A generic saw palmetto oil inhibited biofilm formation by Staphylococcus aureus, Escherichia coli O157:H7 and fungal Candida albicans without affecting their planktonic cell growth. Two main components of the oil, lauric acid and myristic acid, are responsible for this antibiofilm activity. Their antibiofilm activities were observed in dual-species biofilms as well as three-species biofilms of S. aureus, E. coli O157:H7 and C. albicans. Transcriptomic analysis showed that lauric acid and myristic acid repressed the expressions of haemolysin genes (hla and hld) in S. aureus, several biofilm-related genes (csgAB, fimH and flhD) in E. coli and hypha cell wall gene HWP1 in C. albicans, which supported biofilm inhibition. Also, saw palmetto oil, lauric acid and myristic acid reduced virulence of three microbes in a nematode infection model and exhibited minimal cytotoxicity. Furthermore, combinatorial treatment of fatty acids and antibiotics showed synergistic antibacterial efficacy against S. aureus and E. coli O157:H7. These results demonstrate that saw palmetto oil and its main fatty acids might be useful for controlling bacterial infections as well as multispecies biofilms.

The Use of Telemedicine to Support Interventional Pain Care: Case Series and Commentary

Benedict J. Alter , MD, PhD,* Rohit Navlani, DO,* Leath Abdullah, MD,* Ajay D. Wasan, MD, MSc,*,† and Edward Heres, MD*

Departments of *Anesthesiology and Perioperative Medicine; and † Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Benedict J. Alter and Rohit Navlani contributed equally to this work.

Funding sources: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the International Anesthesia Research Society in the form of the Mentored Research Award (B.J.A.) and the American Academy of Pain Medicine Early Investigator Research Grant (B.J.A.).

Conflicts of interest: There are no conflicts of interest to report.

The role of eHealth, telehealth, and telemedicine for chronic disease patients during COVID-19 pandemic: A rapid systematic review

Hind Bitar1 and Sarah Alismail2

1 Department of Information Systems, King Abdulaziz University, Jeddah,

Saudi Arabia

2 Center for Information Systems & Technology, Claremont Graduate

University, Claremont, USA

Corresponding author:

Hind Bitar, Department of Information Systems, King Abdulaziz University,

Al Ehtifalat St, Jeddah 21589, Saudi Arabia.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Objective: To summarize the current status of, and the current expert opinions, recommendation and evidence associated with the use and implementation of electronic health (eHealth), telemedicine, and/or telehealth to provide healthcare services for chronic disease patients during the COVID-19 pandemic.

Materials and methods: We searched four electronic databases (PubMed, Google Scholar, Science Direct, and Web of Science Core Collection) to identify relevant articles published between 2019 and 2020. Searches were restricted to English language articles only. Two independent reviewers screened the titles, abstracts, and keywords for relevance. The potential eligible articles, papers with no abstract, and those that fall into the uncertain category were read in full text independently. The reviewers met and discussed which articles to include in the final review and reached a consensus.

Results: We identified 51 articles of which 25 articles met the inclusion criteria. All included articles indicated the promising potential of eHealth, telehealth, and/or telemedicine solutions in delivering healthcare services to patients living with chronic diseases/conditions during the COVID-19 pandemic. We synthesized the main findings into ten usages and eight recommendations concerning the different activities for delivering healthcare services remotely for those living with chronic diseases/conditions in the era of COVID-19.

Discussion and conclusions: There is limited evidence available about the effectiveness of such solutions. Further research is required during this pandemic to improve the credibility of evidence on telemedicine, telehealth, and/or eHealth-related outcomes for those living with chronic diseases.

Keywords

Chronic, eHealth, telehealth, telemedicine, technology Submission date: 22 August 2020; Acceptance date: 20 March 2021

Opportunities of Telemedicine for Orthopedics and Trauma Surgery

Michael Nerlich1*, Tanja Herbst1 , Antonio Ernstberger1 , Markus Blaetzinger2

1 Department of Trauma Surgery, University Hospital Regensburg, Regensburg, Germany

2 AUC - Akademie der Unfallchirurgie GmbH Munich, Munich, Germany

Corresponding Author: Michael Nerlich, MD, Professor, Department of Trauma Surgery, University Hospital Regensburg, Regensburg, Germany. Tel: 0941/944-6805, Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Received February 4, 2019; Accepted April 25, 2019; Online Published June 6, 2019

Abstract

       Today telemedicine, or eHealth, is an important tool in everyday medical life. In all areas, from the preclinical to aftercare, significant improvements in communication structures have been seen in various eHealth options, which have had significant, positive effects on the quality of patient care in orthopedics and trauma surgery. Initially, there were several isolated solutions and many small individual projects; however, there was a lack of interdisciplinary and comprehensive systems in all healthcare fields. The German Trauma Society (DGU) together with the AUC GmbH took the lead and paved the way for a modulated, comprehensive, interface-compatible teleradiology system. Nevertheless, there are still deficits across all sectors which, in the future, will need to be optimized by eHealth methods and systems. Overall, there is an effort towards patient-centered solutions (patient empowerment). In Germany, telemedicine has gradually gained acceptance in various sectors and is being used nationwide. Telemedicine has proven itself, especially in trauma networks.

Keywords: Telemedicine, Teleradiology, eHealth, Orthopaedics, Trauma Surgery, Patient Care, Patient Participation

The Internet Hospital as a Telehealth Model in China: Systematic Search and Content Analysis

Yangyang Han, BS, Reidar K Lie, MD, PhD, and Rui Guo, PhD

Abstract

Background

The internet hospital is an innovative organizational form and service mode under the tide of internet plus in the Chinese medical industry. It is the product of the interaction between consumer health needs and supply-side reform. However, there has still been no systematic summary of its establishment and definition, nor has there been an analysis of its service content.

Objective

The primary purpose of this study was to understand the definition, establishment, and development status of internet hospitals.

Methods

Data on internet hospitals were obtained via the Baidu search engine for results up until January 1, 2019. Based on the results of the search, we obtained more detailed information from the official websites and apps of 130 online hospitals and formed a database for descriptive analysis.

Results

By January 2019, the number of registered internet hospitals had expanded to approximately 130 in 25 provinces, accounting for 73.5% of all provinces or province-level municipalities in China. Internet hospitals, as a new telehealth model, are distinct but overlap with online health, telemedicine, and mobile medical. They offer four kinds of services—convenience services, online medical services, telemedicine, and related industries. In general, there is an underlying common treatment flowchart of care in ordinary and internet hospitals. There are three different sponsors—government-led integration, hospital-led, and enterprise-led internet hospitals—for which stakeholders have different supporting content and responsibilities.

Conclusions

Internet hospitals are booming in China, and it is the joint effort of the government and the market to alleviate the coexistence of shortages of medical resources and wasted medical supplies. The origin of internet hospitals in the eastern and western regions, the purpose of the establishment initiator, and the content of online and offline services are different. Only further standardized management and reasonable industry freedom can realize the original intention of the internet hospital of meeting various health needs.

Keywords: Internet hospital, telehealth, telemedicine, ehealth, digital health, digital medicine, health services research, China

Does telemedicine reduce the carbon footprint of healthcare? A systematic review

Authors: Amy Purohit,A James SmithB and Arthur HibbleC

ABSTRACT

       In the rapidly progressing field of telemedicine, there is a multitude of evidence assessing the effectiveness and financial costs of telemedicine projects; however, there is very little assessing the environmental impact despite the increasing threat of the climate emergency. This report provides a systematic review of the evidence on the carbon footprint of telemedicine. The identified papers unanimously report that telemedicine does reduce the carbon footprint of healthcare, primarily by reduction in transport-associated emissions. The carbon footprint savings range between 0.70–372 kg CO2e per consultation. However, these values are highly context specific. The carbon emissions produced from the use of the telemedicine systems themselves were found to be very low in comparison to emissions saved from travel reductions. This could have wide implications in reducing the carbon footprint of healthcare services globally. In order for telemedicine services to be successfully implemented, further research is necessary to determine context-specific considerations and potential rebound effects.

KEYWORDS: telemedicine, sustainability, e-health, carbon footprint

DOI: 10.7861/fhj.2020-0080