Anna Ericsson a,* , Karin Borgstrom¨ b,c , Christine Kumlien a,c,d , Magdalena Gershater Annersten a,c , Tautgirdas Ruzgas b,c , Johan Engblom b,c , Petri Gudmundsson b,c , Victoria Lazer a , Skaidre Jankovskaja b,c , Eva Lavant b,c , Sophia Ågren-Witteschus d , Sebastian Bjorklund ¨ b,d , Saman Salim e,f , Mikael Åstrom¨ g , Stefan Acosta f
a Department of Care Science, Faculty of Health and Society, Malm¨ o University, Malm¨ o, Sweden
b Department of Biomedical Science, Faculty of Health and Society, Malm¨ o University, Malm¨ o, Sweden
c Biofilms – Research Center for Biointerfaces, Malm¨ o University, Malm¨ o, Sweden
d Department of Cardiothoracic and Vascular Surgery, Skåne University Hospital, Malm¨ o, Sweden
e Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark
f Department of Clinical Sciences, Lund University, Malmo, ¨ Sweden
g StatCons, Sweden
ARTICLE INFO
Keywords: Diabetes mellitus Dry feet Prevention Foot-xerosis Self-care
ABSTRACT
Introduction: To minimize the risk of developing foot-ulcers, persons with diabetes are given the advice to daily inspect their feet and to apply skincare formulations. However, commercially available skincare products have rarely been developed and evaluated for diabetes foot care specifically. The primary aim of this randomized controlled trial (RCT) is to evaluate the effects in reducing foot xerosis in persons with diabetes without footulcers using two skincare creams containing different humectants (interventions) against a cream base nonhumectant (comparator). Secondary outcomes are to evaluate differences on skin barrier integrity, lowmolecular weight biomarkers and skin microbiota, microcirculation including transcutaneous oxygen pressure, degree of neuropathy, and HbA1c between intervention-comparator creams.
Methods: Two-armed double-blind RCT, registered in ClinicalTrials.gov Identifier: NCT06427889. With 80 % power, two-tailed significance of 2.5 % in each arm, 39 study persons is needed in each arm, total 78 persons, 98 including dropouts, to be able to prove a reduction of at least one category in the Xerosis Severity Scale with the intervention creams compared to the comparator. In one arm, each participant will treat one foot with one of the intervention creams (Oviderm® or Canoderm®), while the opposite foot will be treated with the comparator cream (Decubal®lipid cream), twice a day. If needed, participants are enrolled after a wash-out period of two weeks. The participants will undergo examinations at baseline, day 14 and day 28.
Discussion: This RCT evaluate the potential effects of humectants in skin creams against foot xerosis in persons with diabetes.
Ha Young Park a , Min Ho Kang a , Guewha Lee b , Jin Woo Kim a,c,*
a Department of Food Science, Sunmoon University, Chungcheongnam-do, Republic of Korea
b Hu evergreen Pharm Inc., Incheon, Republic of Korea
c Center for Next-Generation Semiconductor Technology, Sun Moon University, Chungnam, Republic of Korea
Keywords: Ginseng non-edible callus Extracellular vesicle Skin regeneration Collagen synthesis Proliferation
1 . ABSTRACT
Background: This study aimed to investigate the effects of ginseng non-edible callus-derived extracellular vesicle (GNEV) on skin regeneration, particularly focusing on its impact on proliferation and migration in human dermal fibroblast (HDF).
Methods: GNEV was isolated from ginseng non-edible callus using sequential filtration and size exclusion chromatography (SEC). The extracellular vesicle was characterized using nanoparticle tracking analysis (NTA). HDF was treated with various concentrations of GNEV, and cell viability, proliferation, and migration were assessed using MTT and scratch wound healing assays. Gene expression related to collagen synthesis (TGF-β, SMAD-2, SMAD-3, COL1A1) was measured using RT-PCR.
Results: Treatment of HDF with GNEV resulted in a significant 2.5-fold increase in cell migration compared to the non-treated group. Furthermore, GNEV demonstrated the upregulation of collagen synthesis genes, specifically TGF-β, SMAD-2, SMAD-3, and COL1A1, by 41.7 %, 59.4 %, 60.2 %, and 21.8 %, respectively. These findings indicated that GNEV activates the TGF-β/SMAD signaling pathway, showcasing its potential to induce skin
Conclusions: In conclusion, GNEV exhibits a notable ability to enhance skin regeneration through its stimulatory effects on cell migration and the upregulation of key collagen synthesis genes. The activation of the TGF-β/SMAD signaling pathway further suggests the potential of GNEV as a promising candidate for drug delivery systems in the fields of cosmetics and pharmaceuticals, opening avenues for further research and application in skincare and dermatology
擅长大面积深度烧伤的早期救治、各种烧烫伤创面的综合处理、烧伤后瘢痕增生挛缩畸形的修复。长期致力于急性皮肤缺损、慢性皮肤溃疡(褥疮、糖尿病足等)的外科治疗。
南方医科大学珠江医院烧伤整形科主任,广东省医疗行业协会伤口管理分会副主委。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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