李孝建

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26 8月 2019

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Author : 伤口世界

专长：重症烧伤救治。广东省医学会烧伤科分会主任委员、广东省医疗行业协会伤口管理分会副主委。

广东红十字会医院烧伤整形科主任医师，博士研究生导师。烧伤科大主任、烧伤ICU主任。

Latest from 伤口世界

Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells
Motor and vestibular signals in the visual cortex permit the separation of self versus externally generated visual motion
Mapping the landscape of social behavior
Large language models deconstruct the clinical intuition behind diagnosing autism
Jumbo phage killer immune system targets early infection of nucleus-forming phages

K2 Content

Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells 2025-07-09 00:00
Motor and vestibular signals in the visual cortex permit the separation of self versus externally generated visual motion 2025-07-04 00:00

Mateo Ve´ lez-Fort,1,3 Lee Cossell,1,3 Laura Porta,1 Claudia Clopath,1,2 and Troy W. Margrie1,4,*

1 Sainsbury Wellcome Centre, University College London, London, UK

2 Bioengineering Department, Imperial College London, London, UK

3 These authors contributed equally

4 Lead contact

*Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

https://doi.org/10.1016/j.cell.2025.01.032

SUMMARY

Knowing whether we are moving or something in the world is moving around us is possibly the most critical sensory discrimination we need to perform. How the brain and, in particular, the visual system solves this motion-source separation problem is not known. Here, we find that motor, vestibular, and visual motion signals are used by the mouse primary visual cortex (VISp) to differentially represent the same visual flow information according to whether the head is stationary or experiencing passive versus active translation. During locomotion, we find that running suppresses running-congruent translation input and that translation signals dominate VISp activity when running and translation speed become incongruent. This cross-modal interaction between the motor and vestibular systems was found throughout the cortex, indicating that running and translation signals provide a brain-wide egocentric reference frame for computing the internally generated and actual speed of self when moving through and sensing the external world.
Mapping the landscape of social behavior 2025-07-03 00:00

Ugne Klibaite,1,4,* Tianqing Li,2,4 Diego Aldarondo,1,3 Jumana F. Akoad,1 Bence P. O¨ lveczky,1,* and Timothy W. Dunn2,5,*

1 Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA

2 Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA

3 Present address: Fauna Robotics, New York, NY 10003, USA

4 These authors contributed equally

5 Lead contact

*Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (U.K.), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (B.P.O¨ .), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (T.W.D.)

https://doi.org/10.1016/j.cell.2025.01.044

SUMMARY

Social interaction is integral to animal behavior. However, lacking tools to describe it in quantitative and rigorous ways has limited our understanding of its structure, underlying principles, and the neuropsychiatric disorders, like autism, that perturb it. Here, we present a technique for high-resolution 3D tracking of postural dynamics and social touch in freely interacting animals, solving the challenging subject occlusion and partassignment problems using 3D geometric reasoning, graph neural networks, and semi-supervised learning. We collected over 110 million 3D pose samples in interacting rats and mice, including seven monogenic autism rat lines. Using a multi-scale embedding approach, we identified a rich landscape of stereotyped actions, interactions, synchrony, and body contacts. This high-resolution phenotyping revealed a spectrum of changes in autism models and in response to amphetamine not resolved by conventional measurements. Our framework and large library of interactions will facilitate studies of social behaviors and their neurobiological underpinnings.

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

李孝建

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Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

李孝建

Latest from 伤口世界

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