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    蔡道章院长

    Custom Mod Mega1

    主任医师、教授、博导,南方医科大学第三附属医院(广东省骨科医院)院长

    • 中德骨科伤口管理学校校长
    • 广东省骨科研究院运动医学研究所所长
    • 广东省内运动医学专业唯一的博士研究生导师
    • 美国哈弗大学医学院骨科访问学者
    • 专业特长处于省内领先、国内或国际先进水平以上
    • 2018年获得“国之名医卓越建树”荣誉称号
    • 2017年被评为全国卫生计生系统先进工作者、广东省医学领军人才
    • 中国医师协会运动医师分会副会长
    • STCOT中国部运动医学分会副主任委员
    • 广东省医学会关节外科分会主任委员
    • 广东省医学会运动医学会分会名誉主任委员
    • 独立承担过国家“863”课题,主持过10余项省、部级科研项目
    • 多份专业杂志编委
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    最新文献
    • Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits 2025-07-15 00:00

      Loϊc Binan,1,2 Aiping Jiang,3,4,5 Serwah A. Danquah,1,6,12 Vera Valakh,1,6,13 Brooke Simonton,2,14 Jon Bezney,2,15 Robert T. Manguso,3,4,5 Kathleen B. Yates,3,4,5 Ralda Nehme,6 Brian Cleary,7,8,9,10,11,* and Samouil L. Farhi1,16,*

      1 Spatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

      2 Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

      3 Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA

      4 Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02144, USA

      5 Department of Medicine, Harvard Medical School, Boston, MA 02115, USA

      6 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

      7 Faculty of Computing and Data Sciences, Boston University, Boston, MA 02215, USA

      8 Department of Biology, Boston University, Boston, MA 02215, USA

      9 Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA

      10 Program in Bioinformatics, Boston University, Boston, MA 02215, USA

      11 Biological Design Center, Boston University, Boston, MA 02215, USA

      12 Present address: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA

      13 Present address: Stoke Therapeutics, Bedford, MA, USA

      14 Present address: The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

      15 Present address: Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA

      16 Lead contact

      *Correspondence: bcleary@bu.edu (B.C.), sfarhi@broadinstitute.org (S.L.F.)

      https://doi.org/10.1016/j.cell.2025.02.012

      SUMMARY

      Pooled optical screens have enabled the study of cellular interactions, morphology, or dynamics at massive scale, but they have not yet leveraged the power of highly plexed single-cell resolved transcriptomic readouts to inform molecular pathways. Here, we present a combination of imaging spatial transcriptomics with parallel optical detection of in situ amplified guide RNAs (Perturb-FISH). Perturb-FISH recovers intracellular effects that are consistent with single-cell RNA-sequencing-based readouts of perturbation effects (Perturb-seq) in a screen of lipopolysaccharide response in cultured monocytes, and it uncovers intercellular and density-dependent regulation of the innate immune response. Similarly, in three-dimensional xenograft models, Perturb-FISH identifies tumor-immune interactions altered by genetic knockout. When paired with a functional readout in a separate screen of autism spectrum disorder risk genes in human-induced pluripotent stem cell (hIPSC) astrocytes, Perturb-FISH shows common calcium activity phenotypes and their associated genetic interactions and dysregulated molecular pathways. Perturb-FISH is thus a general method for studying the genetic and molecular associations of spatial and functional biology at single-cell resolution.

    • Resurrection of endogenous retroviruses during aging reinforces senescence 2025-07-11 00:00

      Xiaoqian Liu,1,5,6,7,21 Zunpeng Liu,1,5,7,21 Zeming Wu,2,5,7,21 Jie Ren,3,5,7,21 Yanling Fan,3,7 Liang Sun,9 Gang Cao,8 Yuyu Niu,11,12,13 Baohu Zhang,1,7 Qianzhao Ji,2,7 Xiaoyu Jiang,2,7 Cui Wang,3,7 Qiaoran Wang,3,7 Zhejun Ji,1,5,7 Lanzhu Li,2,7 Concepcion Rodriguez Esteban,18 Kaowen Yan,2,5,7 Wei Li,4 Yusheng Cai,2,5,7 Si Wang,4,5,7,15,16 Aihua Zheng,7,19 Yong E. Zhang,7,14 Shengjun Tan,14 Yingao Cai,7,14 Moshi Song,2,5,6,7 Falong Lu,7,10 Fuchou Tang,17 Weizhi Ji,11,12,20 Qi Zhou,1,5,6,7,20 Juan Carlos Izpisua Belmonte,18,20 Weiqi Zhang,3,5,7,* Jing Qu,1,5,6,7,* and Guang-Hui Liu2,4,5,6,7,22,*

      1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

       2 State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

      3 CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China

      4 Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

      5 Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

      6 Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

      7 University of Chinese Academy of Sciences, Beijing 100049, China

      8 State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China

      9 NHC Beijing Institute of Geriatrics, NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine of Chinese Academy of Medical Sciences, National Center of Gerontology/Beijing Hospital, Beijing 100730, China

      10 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China

      11 State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China

      12 Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China

      13 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China

      14 Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

      15 Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China

      16 The Fifth People’s Hospital of Chongqing, Chongqing 400062, China

      17 Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China

      18 Altos Labs, Inc., San Diego, CA 94022, USA

      19 State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

      20 Senior author

      21 These authors contributed equally

      22 Lead contact

      *Correspondence: zhangwq@big.ac.cn (W.Z.), qujing@ioz.ac.cn (J.Q.), ghliu@ioz.ac.cn (G.-H.L.)

      https://doi.org/10.1016/j.cell.2022.12.017

      SUMMARY

      Whether and how certain transposable elements with viral origins, such as endogenous retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the aging process is largely unknown. In human senescent cells, we found that HERVK (HML-2), the most recently integrated human ERVs, are unlocked to transcribe viral genes and produce retrovirus-like particles (RVLPs). These HERVK RVLPs constitute a transmissible message to elicit senescence phenotypes in young cells, which can be blocked by neutralizing antibodies. The activation of ERVs was also observed in organs of aged primates and mice as well as in human tissues and serum from the elderly. Their repression alleviates cellular senescence and tissue degeneration and, to some extent, organismal aging. These findings indicate that the resurrection of ERVs is a hallmark and driving force of cellular senescence and tissue aging.

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22 10月 2019
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Author :   伤口世界
王春兰

护理学本科毕业,上海交通大学医学院附属瑞金医院烧伤科总带教、创面修复中心护理组长、创面治疗师、中国创面修复专科建设“1239”三年行动计划专家委员会委员。

Latest from  伤口世界

  • Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits
  • Resurrection of endogenous retroviruses during aging reinforces senescence
  • Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells
  • Motor and vestibular signals in the visual cortex permit the separation of self versus externally generated visual motion
  • Mapping the landscape of social behavior

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  • K2 Content
  • Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits 2025-07-15 00:00

    Loϊc Binan,1,2 Aiping Jiang,3,4,5 Serwah A. Danquah,1,6,12 Vera Valakh,1,6,13 Brooke Simonton,2,14 Jon Bezney,2,15 Robert T. Manguso,3,4,5 Kathleen B. Yates,3,4,5 Ralda Nehme,6 Brian Cleary,7,8,9,10,11,* and Samouil L. Farhi1,16,*

    1 Spatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

    2 Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

    3 Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA

    4 Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02144, USA

    5 Department of Medicine, Harvard Medical School, Boston, MA 02115, USA

    6 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

    7 Faculty of Computing and Data Sciences, Boston University, Boston, MA 02215, USA

    8 Department of Biology, Boston University, Boston, MA 02215, USA

    9 Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA

    10 Program in Bioinformatics, Boston University, Boston, MA 02215, USA

    11 Biological Design Center, Boston University, Boston, MA 02215, USA

    12 Present address: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA

    13 Present address: Stoke Therapeutics, Bedford, MA, USA

    14 Present address: The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    15 Present address: Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA

    16 Lead contact

    *Correspondence: bcleary@bu.edu (B.C.), sfarhi@broadinstitute.org (S.L.F.)

    https://doi.org/10.1016/j.cell.2025.02.012

    SUMMARY

    Pooled optical screens have enabled the study of cellular interactions, morphology, or dynamics at massive scale, but they have not yet leveraged the power of highly plexed single-cell resolved transcriptomic readouts to inform molecular pathways. Here, we present a combination of imaging spatial transcriptomics with parallel optical detection of in situ amplified guide RNAs (Perturb-FISH). Perturb-FISH recovers intracellular effects that are consistent with single-cell RNA-sequencing-based readouts of perturbation effects (Perturb-seq) in a screen of lipopolysaccharide response in cultured monocytes, and it uncovers intercellular and density-dependent regulation of the innate immune response. Similarly, in three-dimensional xenograft models, Perturb-FISH identifies tumor-immune interactions altered by genetic knockout. When paired with a functional readout in a separate screen of autism spectrum disorder risk genes in human-induced pluripotent stem cell (hIPSC) astrocytes, Perturb-FISH shows common calcium activity phenotypes and their associated genetic interactions and dysregulated molecular pathways. Perturb-FISH is thus a general method for studying the genetic and molecular associations of spatial and functional biology at single-cell resolution.

  • Resurrection of endogenous retroviruses during aging reinforces senescence 2025-07-11 00:00

    Xiaoqian Liu,1,5,6,7,21 Zunpeng Liu,1,5,7,21 Zeming Wu,2,5,7,21 Jie Ren,3,5,7,21 Yanling Fan,3,7 Liang Sun,9 Gang Cao,8 Yuyu Niu,11,12,13 Baohu Zhang,1,7 Qianzhao Ji,2,7 Xiaoyu Jiang,2,7 Cui Wang,3,7 Qiaoran Wang,3,7 Zhejun Ji,1,5,7 Lanzhu Li,2,7 Concepcion Rodriguez Esteban,18 Kaowen Yan,2,5,7 Wei Li,4 Yusheng Cai,2,5,7 Si Wang,4,5,7,15,16 Aihua Zheng,7,19 Yong E. Zhang,7,14 Shengjun Tan,14 Yingao Cai,7,14 Moshi Song,2,5,6,7 Falong Lu,7,10 Fuchou Tang,17 Weizhi Ji,11,12,20 Qi Zhou,1,5,6,7,20 Juan Carlos Izpisua Belmonte,18,20 Weiqi Zhang,3,5,7,* Jing Qu,1,5,6,7,* and Guang-Hui Liu2,4,5,6,7,22,*

    1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

     2 State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

    3 CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China

    4 Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

    5 Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

    6 Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

    7 University of Chinese Academy of Sciences, Beijing 100049, China

    8 State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China

    9 NHC Beijing Institute of Geriatrics, NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine of Chinese Academy of Medical Sciences, National Center of Gerontology/Beijing Hospital, Beijing 100730, China

    10 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China

    11 State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China

    12 Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China

    13 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China

    14 Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

    15 Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China

    16 The Fifth People’s Hospital of Chongqing, Chongqing 400062, China

    17 Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China

    18 Altos Labs, Inc., San Diego, CA 94022, USA

    19 State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

    20 Senior author

    21 These authors contributed equally

    22 Lead contact

    *Correspondence: zhangwq@big.ac.cn (W.Z.), qujing@ioz.ac.cn (J.Q.), ghliu@ioz.ac.cn (G.-H.L.)

    https://doi.org/10.1016/j.cell.2022.12.017

    SUMMARY

    Whether and how certain transposable elements with viral origins, such as endogenous retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the aging process is largely unknown. In human senescent cells, we found that HERVK (HML-2), the most recently integrated human ERVs, are unlocked to transcribe viral genes and produce retrovirus-like particles (RVLPs). These HERVK RVLPs constitute a transmissible message to elicit senescence phenotypes in young cells, which can be blocked by neutralizing antibodies. The activation of ERVs was also observed in organs of aged primates and mice as well as in human tissues and serum from the elderly. Their repression alleviates cellular senescence and tissue degeneration and, to some extent, organismal aging. These findings indicate that the resurrection of ERVs is a hallmark and driving force of cellular senescence and tissue aging.

  • Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells 2025-07-09 00:00

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2019广东省医疗行业协会伤口管理分会年会

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  • 2019年6月15日 中国广州
  • 主办单位:广东省医疗行业协会伤口管理分会

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