王肃生

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25 10月 2019

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Author : 伤口世界

专业方向：对颌面部与躯干和四肢的组织缺损、畸形、溃面，各类体表的良恶性肿和斑痣瘢痕，周围血管疾病，手部外伤和畸形等病症有丰富的诊治经验。

整形外科主任，广东医师协会整形分会副主任委员，广州医学会医学美学美容分会主任委员

Latest from 伤口世界

Anti-Aging Effects of Flavonoids from Plant Extracts
Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+ ) by Synergistic Inhibition of CD38 Expression
Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review
Holistic investigation of the anti-wrinkle and repair efficacy of a facial cream enriched with C-xyloside
Mitigating Glycation and Oxidative Stress in Aesthetic Medicine: Hyaluronic Acid and Trehalose Synergy for Anti-AGEs Action in Skin Aging Treatment

K2 Content

Anti-Aging Effects of Flavonoids from Plant Extracts 2025-05-08 00:00

Bogdan Păcularu-Burada 1,2 , Alexandru-Ionut, Cîrîc 3,* and Mihaela Begea 3

1 ICA Research & Development S.R.L., 202 Splaiul Independent,ei, 060021 Bucharest, Romania; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Dan Voiculescu Foundation for the Development of Romania, 011885 Bucharest, Romania

3 Faculty of Biotechnical Systems Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independent,ei, 060042 Bucharest, Romania; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Citation: Păcularu-Burada, B.; Cîrîc, A.-I.; Begea, M. Anti-Aging Effects of Flavonoids from Plant Extracts. Foods

2024, 13, 2441. https://doi.org/ 10.3390/foods13152441

Academic Editor: Barry Parsons

Received: 4 July 2024

Revised: 25 July 2024

Accepted: 29 July 2024

Published: 2 August 2024

Copyright: © 2024 by the authors.

Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Abstract: Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues’ and cells’ morphology and functionality and consequently being responsible for aging-related diseases. Taking into account the actual preoccupations of both consumers and researchers, healthy anti-aging alternatives are being intensively studied in order to address such concerns. Due to their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights the possibilities to use flavonoids extracted from various plants for their antiaging potential on the skin, brain, and heart. Moreover, their anticarcinogenic, anti-inflammatory, and anti-diabetic properties are summarized, along with the senescence-associated mechanisms. Both the nutraceutical and cosmeceutical fields are continuously developing and flavonoids originating from plants are promising candidates to obtain such products. Thus, the bioactive compounds’ extraction and their subsequent involvement in innovative product manufacturing must be carefully performed while being aware of the various intrinsic and extrinsic factors that may affect the phytochemicals’ structures, bioavailability, and health effects.

Keywords: flavonoids; senescence; diseases; anti-aging; nutraceuticals
Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+ ) by Synergistic Inhibition of CD38 Expression 2025-05-07 00:00

Seongsu Kang 1 , Jiwon Park 1 , Zhihong Cheng 2 , Sanghyun Ye 1 , Seung-Hyun Jun 1,* and Nae-Gyu Kang 1,*

1 LG Household and Health Care R&D Center, Seoul 07795, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.K.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (J.P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.Y.)

2 Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.-H.J.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (N.-G.K.); Tel.: +82-2-6980-1239 (S.-H.J.); +82-2-6980-1533 (N.-G.K.)

Citation: Kang, S.; Park, J.; Cheng, Z.; Ye, S.; Jun, S.-H.; Kang, N.-G. Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+ ) by Synergistic Inhibition of CD38 Expression. Cells 2024, 13, 1799.

https://doi.org/10.3390/ cells13211799

Academic Editor: Paweł Kordowitzki

Received: 8 October 2024

Revised: 28 October 2024

Accepted: 28 October 2024

Published: 30 October 2024

Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Abstract: Nicotinamide adenine dinucleotide (NAD+ ) is indispensable for the regulation of biological metabolism. Previous studies have revealed its role in aging and degenerative diseases, while crucially showing that supplementation with NAD+ or its precursors could ameliorate or reverse the progression of aging. Despite extensive evidence for the role and action of NAD+ in aging, its pharmacological activity on the skin, or even its mechanism, has not been elucidated. In this study, we established a novel approach to effectively utilize NAD+ for skin anti-aging by enhancing the pharmacological efficacy of exogenous NAD+ using a phytochemical complex consisting of quercetin, and enoxolone through inhibition of CD38. Through the comprehensive in vitro experiments based on human fibroblasts, we observed that exogenous NAD+ could exert protective effects against both extrinsic aging induced by ultraviolet light exposure and intrinsic aging. Additionally, we found that its effects were significantly boosted by quercetin and enoxolone. In this in-depth study, we demonstrated that these beneficial effects are mediated by improved sirtuin activation, autophagy, and mitochondrial functionality. Our approach is expected to verify the applicability of the topical application of NAD+ and offer more effective solutions for the unmet needs of patients and consumers who demand more effective anti-aging effects.

Keywords: nicotinamide adenine dinucleotide (NAD+ ); quercetin; enoxolone; anti-aging; topical application; CD38
Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review 2025-05-06 00:00

Andrada Pintea 1 , Andrei Manea 1,* , Cezara Pintea 1 , Robert-Alexandru Vlad 2 , Magdalena Bîrsan 3 , Paula Antonoaea 2 , Emöke Margit Rédai 2 and Adriana Ciurba 2

1 Medicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania

2 Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.C.)

3 Department of Drug Industry and Pharmaceutical Biotechnology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Academic Editors: Maurice Am Van

Steensel and Jean-Luc Poyet

Received: 29 November 2024

Revised: 28 December 2024

Accepted: 8 January 2025

Published: 9 January 2025

Citation: Pintea, A.; Manea, A.; Pintea, C.; Vlad, R.-A.; Bîrsan, M.; Antonoaea, P.; Rédai, E.M.; Ciurba, A.

Peptides: Emerging Candidates for the Prevention and Treatment of Skin

Senescence: A Review. Biomolecules 2025, 15, 88. https://doi.org/ 10.3390/biom15010088

Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).

Abstract: One class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products. Peptides are novel active ingredients that improve collagen synthesis, enhance skin cell proliferation, or decrease inflammation. Based on their mechanism of action, they can be classified into signal peptides, carrier peptides, neurotransmitter inhibitor peptides, and enzyme inhibitor peptides. This review focuses on the main types of peptides and their application in the cosmetic field, underlining their main limitations. One of the most significant drawbacks of cosmetic peptides is their poor permeability through membranes, which limits their delivery and effectiveness. As a result, this review follows the methods used for improving permeability through the stratum corneum. Increasing peptide bioavailability and stability for enhanced delivery to the desired site of action and visible effects have become central points for the latest research due to their promising features. For this purpose, several methods have been identified and described. Physical techniques include thermal ablation (radiofrequency and laser), electrical methods (electroporation, iontophoresis), mechanical approach (microneedles), and ultrasounds. As an alternative, innovative formulations have been developed in nanosystems such as liposomes, niosomes, ethosomes, nanoemulsions, and other nanomaterials to reduce skin irritation and improve product effectiveness. The purpose of this review is to provide the latest information regarding these noteworthy molecules and the reasoning behind their use in cosmetic formulations.

Keywords: cosmetic peptides; anti-aging products; permeability; nano-systems

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

王肃生

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

王肃生

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