王肃生

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25 10月 2019

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Author : 伤口世界

专业方向：对颌面部与躯干和四肢的组织缺损、畸形、溃面，各类体表的良恶性肿和斑痣瘢痕，周围血管疾病，手部外伤和畸形等病症有丰富的诊治经验。

整形外科主任，广东医师协会整形分会副主任委员，广州医学会医学美学美容分会主任委员

Latest from 伤口世界

Enhancement of skin regeneration through activation of TGF-β/SMAD signaling pathway by Panax ginseng meyer non-edible callus-derived extracellular vesicles
Leveraging Single Nucleotide Polymorphism Profiling for Precision Skin Care: How SNPs Shape Individual Responses in Cosmetic Dermatology
Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin
Preparation and Evaluation of Complexed Ubiquinone (Coenzyme Q10) Antiaging Hyaluronic Acid–Vitamin C Serum for Skin Care
Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights

K2 Content

Enhancement of skin regeneration through activation of TGF-β/SMAD signaling pathway by Panax ginseng meyer non-edible callus-derived extracellular vesicles 2025-04-01 00:00

Ha Young Park a , Min Ho Kang a , Guewha Lee b , Jin Woo Kim a,c,*

a Department of Food Science, Sunmoon University, Chungcheongnam-do, Republic of Korea

b Hu evergreen Pharm Inc., Incheon, Republic of Korea

c Center for Next-Generation Semiconductor Technology, Sun Moon University, Chungnam, Republic of Korea

ARTICLE INFO

Keywords: Ginseng non-edible callus Extracellular vesicle Skin regeneration Collagen synthesis Proliferation

1 . ABSTRACT

Background: This study aimed to investigate the effects of ginseng non-edible callus-derived extracellular vesicle (GNEV) on skin regeneration, particularly focusing on its impact on proliferation and migration in human dermal fibroblast (HDF).

Methods: GNEV was isolated from ginseng non-edible callus using sequential filtration and size exclusion chromatography (SEC). The extracellular vesicle was characterized using nanoparticle tracking analysis (NTA). HDF was treated with various concentrations of GNEV, and cell viability, proliferation, and migration were assessed using MTT and scratch wound healing assays. Gene expression related to collagen synthesis (TGF-β, SMAD-2, SMAD-3, COL1A1) was measured using RT-PCR.

Results: Treatment of HDF with GNEV resulted in a significant 2.5-fold increase in cell migration compared to the non-treated group. Furthermore, GNEV demonstrated the upregulation of collagen synthesis genes, specifically TGF-β, SMAD-2, SMAD-3, and COL1A1, by 41.7 %, 59.4 %, 60.2 %, and 21.8 %, respectively. These findings indicated that GNEV activates the TGF-β/SMAD signaling pathway, showcasing its potential to induce skin

Conclusions: In conclusion, GNEV exhibits a notable ability to enhance skin regeneration through its stimulatory effects on cell migration and the upregulation of key collagen synthesis genes. The activation of the TGF-β/SMAD signaling pathway further suggests the potential of GNEV as a promising candidate for drug delivery systems in the fields of cosmetics and pharmaceuticals, opening avenues for further research and application in skincare and dermatology
Leveraging Single Nucleotide Polymorphism Profiling for Precision Skin Care: How SNPs Shape Individual Responses in Cosmetic Dermatology 2025-03-31 00:00

Diala Haykal

Centre Médical Laser Palaiseau, Palaiseau, France

Correspondence: Diala Haykal (docteur.haykal@gmail.com)

Received: 5 December 2024 | Accepted: 15 December 2024

Funding: The author received no specific funding for this work.

Keywords: cosmetic dermatology | genetic predisposition | personalized skincare | precision medicine | single nucleotide polymorphisms (SNPs) profiling
Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin 2025-03-28 00:00

Liang Chen1,2 | Fudi Wang3 | Xiaoyun Hu1,2 | Nihong Li1,2 | Ying Gao4 | Fengfeng Xue5 | Ling Xie1,2 | Min Xie1,2

1 Scientific Research Laboratory, Shanghai Le-Surely Biotechnology Co. Ltd, Shanghai, China |

2 SASELOMO Research Institute and Biological Laboratory, Shanghai Chuanmei Industrial Co. Ltd, Shanghai, China |

3 Evelab Insight (Singapore) Pte. Ltd, Singapore, Singapore |

4 Zhejiang Moda Biotech Co. Ltd, Hangzhou, China |

5 Nanomedicine and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China

Correspondence: Liang Chen (liang_chen13@fudan.edu.cn) | Fengfeng Xue (xuefengfeng@msn.com)

Received: 5 September 2024 | Revised: 25 December 2024 | Accepted: 24 January 2025

Funding: The authors received no specific funding for this work.

Keywords: antiaging | baicalin | bio-vesicle | skin physiology and cell culture | transdermal delivery

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

王肃生

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