伤口世界

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星期五, 30 8月 2019

糖尿病足治疗的“三心”：信心、细心、耐心

原创：十六点五中山二院糖尿病足中心

无数来到我科“中心”的外地病人唯一的理由就是：他们要截我的脚！

星期五, 30 8月 2019

糖尿病足治疗与交响乐

原创：十六点五中山二院糖尿病足中心

糖尿病足的治疗是当今医学界的难题之一，但细细想来，目前糖尿病足的治疗的关键技术好像都不是非常困难，也不是什么高科技，更没有多少“原始创新”。

星期五, 30 8月 2019

为什么糖尿病人足部一个小小的伤口会造成如此严重的后果

原创：十六点五中山二院糖尿病足中心

有些糖尿病人来到中心的糖尿病足工作室，会产生很大的疑问，为什么我的脚明明只有一个很小洞，却在工作室被大大地切开？另外一些患者发现，脚上的一个小小的伤口，几个月甚至几年都不愈合，而另外的一些人却发现，仅仅是剪脚指甲时留下的一个小小的伤口，几天之后自己的脚就变成像猪头一样，到处流脓，而且臭气熏天，苦不堪言。这是为什么？

星期五, 30 8月 2019

糖尿病足患者应该找哪个科看病

原创：十六点五中山二院糖尿病足中心

随着糖尿病患病人数的不断增加，糖尿病足的病人也越来越多，在平时的临床实践中，笔者发现很多糖尿病足病友搞不清楚糖尿病足应该由什么科管？或者说哪个科的医师负责糖尿病足的诊断和治疗。

星期五, 30 8月 2019

糖尿病足患者是否一定要用胰岛素控制血糖？

原创：十六点五中山二院糖尿病足中心

控制血糖是预防糖尿病足最重要的措施之一，也是治疗糖尿病足综合治疗的基础之一。当出现严重的并发症糖尿病足的时候，控制血糖最重要的方法目前一般认为是胰岛素治疗，而且最好是胰岛素的强化治疗。但很多患者不是非常理解，往往产生很多问题，对于其中一些有代表性的问题做一些回答。

星期五, 30 8月 2019

糖尿病足患者为什么要保足

原创：十六点五中山二院糖尿病足中心

有不少医护人员为了糖尿病足病患者殚精竭虑地工作着，但是也有很多人不理解这种工作的意义，认为糖尿病足患者如果尽快截肢（踝关节以上），可以省去很多医疗资源和社会资源的投入，而且目前各种支具的生产越来越精巧、越来越智能、也越来越便宜，这种劳神费力的工作真有意义吗？

K2 Content

异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream 2024-11-19 00:00

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病足治疗的“三心”：信心、细心、耐心

糖尿病足治疗与交响乐

为什么糖尿病人足部一个小小的伤口会造成如此严重的后果

糖尿病足患者应该找哪个科看病

糖尿病足患者是否一定要用胰岛素控制血糖？

糖尿病足患者为什么要保足

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病足治疗的“三心”：信心、细心、耐心

糖尿病足治疗与交响乐

为什么糖尿病人足部一个小小的伤口会造成如此严重的后果

糖尿病足患者应该找哪个科看病

糖尿病足患者是否一定要用胰岛素控制血糖？

糖尿病足患者为什么要保足

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学术会议

伤口世界提示