伤口世界

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星期五, 18 10月 2019

外科换药之一二三四五

axun_dxy 负压引流与创面修复

可以说每一名外科医生都是从换药开始成长起来，恰当的换药能够减轻患者的痛苦，不当的换药可能造成感染、创口不愈合等严重后果。

星期五, 18 10月 2019

再次改良：‘小黑+大白’负压引流治疗大创面

胡海涛负压引流与创面修复

封闭式负压引流起源：

1993年德国Fleischmann教授提出将传统负压引流与现代封闭式敷料相结合的新型疗法，并用它治疗开放性骨折创面，获得了成功。

星期五, 18 10月 2019

晚期回家等死的伤口患者，在护士手里又获得新生！

原创：张桂美、胡海涛负压引流与创面修复

面对晚期肿瘤，医生、护士、患者、家属都很无奈，只能默默的接受！

星期五, 18 10月 2019

糖足患者说：你让我们找得好辛苦！

原创：胡海涛负压引流与创面修复

最近，一位来自广西的伤口患者，出院时说：我这个伤口去广西、广州很多大医院看了，都建议截肢，说不可能保肢的因为病史已经8年了，来时是打算试一试的，结果很意外，历时2月，居然保肢成功，还能走路！

星期五, 18 10月 2019

20天碘伏消毒的伤口肿痛加重，盐水清洗1周痊愈！

原创：胡海涛负压引流与创面修复

今天伤口朋友圈的一个重要知识点：‘碘伏’对创面愈合的‘是与非’！

星期五, 18 10月 2019

被狗咬，该不该打狂犬疫苗？

负压引流与创面修复

以下文章来源于迷途小羔羊9527 ，作者阿莫医生三院

关于狂犬病疫苗注射的问题，经常被问到。

不该打的时候打了，花冤枉钱还遭罪；

该打的时候不打，却又是一朝发病，神仙难救。

因此，该不该打的问题，往往让人左右为难，无论是医生还是患者均受此困扰

K2 Content

An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair 2024-11-25 00:00

Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5

1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea

2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea

4 UltraV Co., Ltd. R&D Center, Seoul, South Korea

5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea

Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 and 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.

Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.

Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.

Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.

KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200
异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

外科换药之一二三四五

再次改良：‘小黑+大白’负压引流治疗大创面

晚期回家等死的伤口患者，在护士手里又获得新生！

糖足患者说：你让我们找得好辛苦！

20天碘伏消毒的伤口肿痛加重，盐水清洗1周痊愈！

被狗咬，该不该打狂犬疫苗？

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

外科换药之一二三四五

再次改良：‘小黑+大白’负压引流治疗大创面

晚期回家等死的伤口患者，在护士手里又获得新生！

糖足患者说：你让我们找得好辛苦！

20天碘伏消毒的伤口肿痛加重，盐水清洗1周痊愈！

被狗咬，该不该打狂犬疫苗？

消息订阅

学术会议

伤口世界提示