伤口世界

电子邮件地址: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

星期一, 14 10月 2019

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第三回）

原创：十六点五中山二院糖尿病足中心

星期一, 14 10月 2019

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第二回）

原创：十六点五中山二院糖尿病足中心

梁某，女，60岁，糖尿病病史7年，平时不规则用药，血糖控制一般。10余天前不小心刺伤左脚第2趾，到当地医院看病，感染扩散，当地医院建议截肢，患者要求转院于2018年10月27日转入我院。

星期一, 14 10月 2019

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第一回）

原创：十六点五中山二院糖尿病足中心

截肢与保肢只差一个中山二院的距离

星期一, 14 10月 2019

病例分享：我院糖尿病足MDT团队成功诊治复杂性左下肢复合溃疡一例

原创：血管工程师血管工程师

胡奶奶今年73岁高龄，10年前发现糖尿病，血糖一直控制不佳，还有高血压等疾病，3年前因右下肢静脉曲张在当地医院做过手术。1月前因左下肢无力、麻木，当地医院考虑为左下肢静脉曲张再次入院行左下肢静脉曲张手术。

星期一, 14 10月 2019

同步报告病例1：TurboHawk斑块旋切系统开通股浅动脉支架内闭塞病例（第一回）

原创：十六点五中山二院糖尿病足中心

张某，男，71岁，因多饮多尿26年，右足溃烂2年入院。

2016年无明显诱因下发现右脚第二脚趾皮肤溃烂发黑，后逐渐累及第一、第三及第四脚趾，周边皮肤发红，疼痛明显，伴低热，遂至外院就诊。

星期一, 14 10月 2019

糖尿病足与全身性炎症反应综合征（SIRS）

中山二院糖尿病足中心

K2 Content

An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair 2024-11-25 00:00

Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5

1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea

2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea

4 UltraV Co., Ltd. R&D Center, Seoul, South Korea

5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea

Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 and 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.

Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.

Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.

Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.

KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200
异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第三回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第二回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第一回）

病例分享：我院糖尿病足MDT团队成功诊治复杂性左下肢复合溃疡一例

同步报告病例1：TurboHawk斑块旋切系统开通股浅动脉支架内闭塞病例（第一回）

糖尿病足与全身性炎症反应综合征（SIRS）

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

同步报告病例2： 截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第三回）

同步报告病例2： 截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第二回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第一回）

病例分享：我院糖尿病足MDT团队成功诊治复杂性左下肢复合溃疡一例

同步报告病例1：TurboHawk斑块旋切系统开通股浅动脉支架内闭塞病例（第一回）

糖尿病足与全身性炎症反应综合征（SIRS）

消息订阅

学术会议

伤口世界提示

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第三回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第二回）