伤口世界

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星期一, 16 9月 2019

精彩案例分享：新生儿头部伤口愈合经过！

原创：李磊负压引流与创面修复

星期一, 16 9月 2019

夜间1点电话催儿子交住院费，原因让医生很感动！

原创：胡海涛负压引流与创面修复

平时工作中，有很多其他特殊患者——熟人、领导介绍的，交费大都不积极，甚至会出现逃费情况，这种情况我遇到过，再次遇到熟人介绍的患者，如果他不担保，其它都得按程序走。

星期一, 16 9月 2019

艾灸致糖足接近截肢，2月花费10万才保下来！

原创：胡海涛负压引流与创面修复

案例介绍

从阳西转来一个严重的糖尿病足患者，当地医院建议截肢，为了保肢，家属驱车几百公里四处求医!

看到病人那一刻，她的病情很重——无精打采、寡言少语，很累很累的样子，近几天胃口很差，有低热，患足没有疼痛，异味很重。

星期一, 16 9月 2019

烂脚丫进行性加重致足肿胀、起水泡，甚至小腿皮下出血！

原创：胡海涛负压引流与创面修复

病例特点：

男性患者，38岁，双足肿痛5天，因为在北京出差，未能及时治疗，病情进行性加重，回到当地治疗。

查体：双足肿胀，右足背多个水泡，小腿皮下淤血，见图

星期一, 16 9月 2019

老师的这个职业病，不要等到烂了才治疗

原创：胡海涛负压引流与创面修复

教师节的今天，介绍一位特殊的患者，他是77岁的退休老师，因为老烂腿痛的忍无可忍时才肯定至医院就诊，高龄+严重的小腿色素沉着+巨大溃疡+静脉曲张，当地多家医院也束手无策。

星期一, 16 9月 2019

慢性伤口，快速愈合的奥秘七招！

原创：胡海涛负压引流与创面修复

为啥，我的治疗患者伤口愈合快速快？

因为外科医生的性格偏急，总是在追求让自己的患者快速康复后出院！

主要原因，找到了让急慢性伤口快速愈合的奥秘！

K2 Content

An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair 2024-11-25 00:00

Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5

1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea

2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea

4 UltraV Co., Ltd. R&D Center, Seoul, South Korea

5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea

Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 and 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.

Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.

Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.

Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.

KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200
异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

精彩案例分享：新生儿头部伤口愈合经过！

夜间1点电话催儿子交住院费，原因让医生很感动！

艾灸致糖足接近截肢，2月花费10万才保下来！

烂脚丫进行性加重致足肿胀、起水泡，甚至小腿皮下出血！

老师的这个职业病，不要等到烂了才治疗

慢性伤口，快速愈合的奥秘七招！

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

精彩案例分享：新生儿头部伤口愈合经过！

夜间1点电话催儿子交住院费，原因让医生很感动！

艾灸致糖足接近截肢，2月花费10万才保下来！

烂脚丫进行性加重致足肿胀、起水泡，甚至小腿皮下出血！

老师的这个职业病，不要等到烂了才治疗

慢性伤口，快速愈合的奥秘七招！

消息订阅

学术会议

伤口世界提示