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Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

This article is excerpted from the 《Frontiers in Physiology》 by Wound World

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This article is excerpted from the 《Frontiers in Nutrition》by Wound World

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Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial 2026-07-28 00:00

Azadeh Dorostkar¹ , Mehdi Ghahartars¹ , Mohammadreza Namazi¹ , Nafiseh Todarbary² , Maryam Hadibarhaghtalab¹ , Maryam Rezaee¹

1 Dermatology Department, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Key words: topical, sodium hypochlorite, acne vulgaris, treatment

Citation: Dorostkar A, Ghahartars M, Namazi M, Todarbary N, Hadibarhaghtalab M, Rezaee M. Sodium hypochlorite 0.005%

versus placebo in the treatment of mild to moderate acne: a double-blind randomized controlled trial. Dermatol Pract Concept.

2021;11(3):e2021046. DOI: https://doi.org/10.5826/dpc.1103a46

Accepted: December 9, 2020; Published: May 20, 2021

Copyright: ©2021 Dorostkar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License

BY-NC-4.0, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors

and source are credited.

Competing interests: The authors have no conflicts of interest to declare.

Funding: None

Corresponding author: Maryam Hadibarhaghtalab, Department of Dermatology, Faghihi Hospital, Zand Street, Shiraz, Iran.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

ABSTRACT

Background: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions.

Objective: This study determined the therapeutic efficacy of topical sodium hypochlorite solution (0.005%) in the treatment of mild to moderate acne lesions.

Methods: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochlorite to placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. The numbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation.

Results: The total number of papules and pustules decreased after topical application of sodium hypochlorite 0.005% for 1 month.

Conclusions: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mild to moderate acne, and its clinical efficacy was evaluated between the male and female groups and between the hormonal and non-hormonal ones.

Trial registration: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code number IRCT20200701047976N1.
Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial 2026-07-28 00:00

Azadeh Dorostkar¹ , Mehdi Ghahartars¹ , Mohammadreza Namazi¹ , Nafiseh Todarbary² , Maryam Hadibarhaghtalab¹ , Maryam Rezaee¹

1 Dermatology Department, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Key words: topical, sodium hypochlorite, acne vulgaris, treatment

Citation: Dorostkar A, Ghahartars M, Namazi M, Todarbary N, Hadibarhaghtalab M, Rezaee M. Sodium hypochlorite 0.005%

versus placebo in the treatment of mild to moderate acne: a double-blind randomized controlled trial. Dermatol Pract Concept.

2021;11(3):e2021046. DOI: https://doi.org/10.5826/dpc.1103a46

Accepted: December 9, 2020; Published: May 20, 2021

Copyright: ©2021 Dorostkar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License

BY-NC-4.0, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors

and source are credited.

Competing interests: The authors have no conflicts of interest to declare.

Funding: None

Corresponding author: Maryam Hadibarhaghtalab, Department of Dermatology, Faghihi Hospital, Zand Street, Shiraz, Iran.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

ABSTRACT

Background: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions.

Objective: This study determined the therapeutic efficacy of topical sodium hypochlorite solution (0.005%) in the treatment of mild to moderate acne lesions.

Methods: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochlorite to placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. The numbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation.

Results: The total number of papules and pustules decreased after topical application of sodium hypochlorite 0.005% for 1 month.

Conclusions: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mild to moderate acne, and its clinical efficacy was evaluated between the male and female groups and between the hormonal and non-hormonal ones.

Trial registration: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code number IRCT20200701047976N1.
Micropore drainage to prevent hematoma in axillary bromhidrosis A comparative study 2026-07-27 00:00

Jiao-Jiao Yang, MBBS^a , Jie-Ling Bai, MBBS^a , Shuai Qiang, PhD^b, Yong Ma, MBBS^c, *

Abstract

Axillary bromhidrosis is characterized by malodor stemming from hyperplastic and hypertrophic apocrine sweat glands. Although surgical excision remains the most definitive treatment, postoperative complications—particularly hematoma—can compromise outcomes and patient satisfaction. This study evaluated the effectiveness of a micropore drainage technique in reducing hematoma and improving overall results. This retrospective comparative study analyzed data from medical records of 73 patients diagnosed with axillary bromhidrosis who underwent surgical treatment at the 3201 Hospital in Hanzhong, China, from January 2020 to January 2024. Patients had initially been randomized into either the experimental group (group A, n = 38), which received micropore drainage combined with subdermal undermining via a miniature incision, or the control group (group B, n = 35), treated by subdermal undermining alone. Inclusion and exclusion criteria were strictly followed during retrospective selection. Outcomes, evaluated by blinded assessors, included malodor elimination, Dermatology Life Quality Index (DLQI) scores, hair growth reduction, scar formation, postoperative complications, and patient satisfaction. Both groups achieved significant improvements in malodor control and DLQI scores. Notably, the hematoma rate was 0% in Group A compared to 11.43% in Group B (P = .02). Group A also demonstrated higher patient satisfaction (81.58% vs 51.43%, P = .01). There were no significant differences between the groups in operative time, scar formation, DLQI improvement, or hair growth reduction. Incorporating micropore drainage into surgical management of axillary bromhidrosis effectively reduces postoperative hematoma and enhances patient satisfaction without increasing operative complexity or compromising apocrine gland removal. This technique shows promise as a safer, more reliable option for axillary bromhidrosis treatment, warranting further validation through larger multicenter studies and longer-term follow-up.

Abbreviations: AB = axillary bromhidrosis, DLQI = Dermatology Life Quality Index.

Keywords: apocrine glands, axillary bromhidrosis, Dermatology Life Quality Index, hematoma, micropore drainage, seroma, surgical treatment

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

Role of Vitamin C in Skin Diseases

Screening method and metabolic analysis of plant anti-aging microorganisms via ammoniainduced senescence in the duckweed Wolffia microscopica

Identification of Flavoanoids From Finger Citron and Evaluation on Their Antioxidative and Antiaging Activities

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Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

Role of Vitamin C in Skin Diseases

Screening method and metabolic analysis of plant anti-aging microorganisms via ammoniainduced senescence in the duckweed Wolffia microscopica

Identification of Flavoanoids From Finger Citron and Evaluation on Their Antioxidative and Antiaging Activities

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