Patrick Bogdanowicz 1,4囚 , Paul Bensadoun 2,4, Maïté Noizet 1 , Benoît Béganton 1 , Armony Philippe 1 , SandrineAlvarez‑Georges 1 , Gautier Doat 3 , AmélieTourette 1 , Sandrine Bessou‑Touya 1 , Jean‑Marc Lemaitre 2囚 & Hélène Duplan 1

1 R&D Pierre Fabre Dermo-Cosmétique & Personal Care, Toulouse, France.

2 INSERM IRMB UMR1183, Hôpital Saint Eloi, Université de Montpellier, Montpellier, France.

3 Laboratoires Dermatologiques Avène, Lavaur, France. 4These authors contributed equally: Patrick Bogdanowicz and Paul Bensadoun.

囚email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Intrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging. Senescent cells have a specific secretome, called the senescence-associated secretory phenotype (SASP) that includes MMPs, CXCLs and S100A8/9. Reducing the SASP with senotherapeutics is a promising strategy to reduce skin aging. Here we evaluated the effect of a formula containing niacinamide and hyaluronic acid, which are known to limit senescence and skin aging. We conducted three different studies. (1) Ex vivo explants treated with the formula had more collagen and glycosaminoglycan. (2) In a clinical trial with forty-four women, two months of treatment improved fne lines, wrinkles, luminosity, smoothness, homogeneity, and plumpness. (3) In a third study on thirty women, we treated one arm for two months and took skin biopsies to study gene expression. 101 mRNAs and 13 miRNAs were differentially expressed. We observed a likely senomorphic efect, as there was a decrease in many SASP genes including MMP12 and CXCL9 and a significant downregulation of autocrine signaling genes: S100A8 and S100A9. These pharmaco-clinical results are the first to demonstrate the senomorphic properties of an effective anti-aging formula in skin.

Merve Tomas1 , Deniz Günal-Köroğlu1 , Senem Kamiloglu2,3, Tugba Ozdal4 and Esra Capanoglu1,5*

*Correspondence: Esra Capanoglu 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

1 Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Türkiye

2 Department of Food Engineering, Faculty of Agriculture, Bursa Uludag University, 16059 Gorukle, Bursa, Türkiye

3 Science and Technology Application and Research Center (BITUAM), Bursa Uludag University, 16059 Gorukle, Bursa, Türkiye

4 Department of Food Engineering, Faculty of Engineering and Natural Sciences, Istanbul Okan University, 34959 Tuzla, Istanbul, Türkiye

5 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China

Abstract

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin’s structural integrity. Carotenoids, vitamins, essential fatty acids, and phenolic compounds work by acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, and elastase, which degrade skin structure, and reducing levels of inflammatory markers (IL-6, IL-8, etc.) and matrix metalloproteinases (MMP-1, MMP- 2) linked to aging. Recent research highlights that plant-based phytochemicals can improve skin elasticity, reduce hyperpigmentation, prevent the breakdown of important skin proteins, and support wound healing, making them valuable components for skin care and treatments. This review explores the multifaceted roles of phytochemicals in maintaining and improving skin health, highlighting their mechanisms of action and potential in skin anti-aging

Keywords Skin care, Anti-aging, Phytochemicals, Polyphenols, Carotenoids, Fatty acids, Saponins, Alkoloids

封红伟 陈丽琴 胡绣华

DOI：10.3969/j.issn.0253-9926.2020.21.004

基金项目：上海市宝山区科学技术委员会科技创新专

项资金项目(17-E-8)

作者单位：200940 上海市第一人民医院宝山分院护理

部

【摘 要】 目的 观察次氯酸消毒液联合湿性愈合方法在慢性伤口中的效果。方法 对 2017 年 1 月至 2019 年 5 月在我院伤口门诊就诊慢性伤口患者(150 例 229 处伤口)，采用随机数字表格法分为观察组(75 例 116 处伤口)，采用次氯酸消毒液联合湿性愈合方法；对照组(75 例 113 处伤口)，采用常规湿性换药方法。比较 2 组患者创面愈合率、愈合时间、换药次数。 结果 观察组的伤口愈合率高于对照组，愈合时间、换药次数均少于对照组，差异有统计学意义(P<0．05)。结论 应用次氯酸消毒液联合湿性愈合方法优于常规湿性愈合方法。

【关键词】 次氯酸；消毒药；伤口愈合

Observation on the curative effect of hypochlorite disinfectant combined with wet healing on chronic wounds

Feng Hongwei, Chen Liqin, Hu Xiuhua．Department of Nursing， Baoshan Branch of Shanghai First People′s Hospital，Shanghai 200940， China

【Abstract】 Objective

To observe the effect of hypochlorite disinfectant combined with wet healing on chronic wounds．

Methods

From January 2017 to May 2019 229 wounds in 150 patients with chronic wounds were randomly divided into two groups： the observation group (116 wounds in 75 patients) of using combination of hypochlorite disinfectant and wet healing method and the control group (113 wounds in 75 patients) of using conventional wet healing method． Wound healing rate， healing time and dressing change times between the two groups were compared． Results The wound healing rate of the observation group was higher than that of the control group (P < 0．05)， and the healing time and dressing change times of the observation group were also lower than those of the conventional group (P< 0．05)． Conclusion

The combination of hypochlorite disinfectant and wet healing method is better than the conven

tional wet healing method．

【Key words】 Hypochlorous acid； Disinfectants； Wound healing

DOI：10.3969/j.issn.0253-9926.2020.21.004

This article is excerpted from the INTERNATIONAL CONSENSUS UPDATE 2022 by Wound World.