伤口世界

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星期二, 15 10月 2019

同步报告病例1（第五回）：TurboHawk斑块旋切系统开通股浅动脉支架闭塞病例

原创：十六点五中山二院糖尿病足中心

换药、换药、换药

继续、继续、继续

星期二, 15 10月 2019

同步报告病例2（第十一回）：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过

原创：十六点五中山二院糖尿病足中心

转眼3周过去了

病人再次回来复诊

回顾一下患者在家换药的历程

2018年12月14日

星期二, 15 10月 2019

同步报告病例2（第十回）：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过

中山二院糖尿病足中心

这只熟悉的脚

已经在一些会议上得到了展示

很多人在关注着你

现在到底如何？

2018年12月5日

星期二, 15 10月 2019

同步报告病例3（第七回）：一个家庭护理失败的案例，并“夹生足”的同步治疗经过

原创：十六点五中山二院糖尿病足中心

经过合作医院差不多20天的治疗

患者再次转入我科

回顾病人这段时间的变化

2018年12月22日

星期二, 15 10月 2019

同步报告病例4（第八回）：没有最烂，只有更烂。一个危重足患者保脚经历

原创：十六点五中山二院糖尿病足中心

在瑟瑟寒风中

我们迎来了新的一年---2019年

可惜在新的一年的第一天

心情如同广州的天气

没有明媚的阳光

也没有和煦的春风

只要冷冷的细雨

星期二, 15 10月 2019

同步报告病例4（第七回）：没有最烂，只有更烂一个危重足患者保脚经历

原创：十六点五中山二院糖尿病足中心

又到了一个治疗的节点

2018年12月21日

患者的左足准备装负压

装负压前的情况为

K2 Content

Efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms 2024-11-27 00:00

Xianghua Zhang1 Delphine Kerob2 Zhongxing Zhang1 Han Tao1 Xiaofeng He3 Yi Yi3 Xiaofeng Fang3 Wenna Wang3 Andrew Steel3

1 L’Oreal Dermatological Beauty, L’Oréal China, Shanghai, China

2 La Roche-Posay Laboratoire Pharmaceutique, Levallois Perret, La Roche-Posay, France

3 Research and Innovation Center, L’Oréal China, Shanghai, China

Correspondence

Xianghua Zhang, L’Oreal Dermatological Beauty, L’Oréal China, Shanghai, China.

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Abstract

Background: Sensitive skin is a common condition affecting a significant proportion of the population, and there is a growing demand for effective and safe management.

Aim: To evaluate the efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate as an optimal care for facial sensitive skin.

Methods: A total of 110 participants (64 in group A and 46 in group B) with facial sensitive skin applied the cream twice daily for 28 days. Group A evaluated their sensitive skin, product efficacy, and product use experience at D0 (15 min), D1, D14, and D28. In group B, skin barrier function-related indicators were measured at baseline and on D1, D7, D14, and D28. Dermatologists evaluated tolerance for all participants.

Results: After 28 days of use, in group A, 100% of participants reported mildness and comfort with product use. Participants demonstrated significant improvements in skin barrier function-related indicators, including increased stratum corneum moisture content, reduced erythema index, elevated sebum content, decreased trans-epidermal water loss, and diminished skin redness parameter a* value (all p < 0.05). Dermatologist evaluations revealed excellent tolerance among all participants.

Conclusion: The panthenol-enriched cream with prebiotics and probiotic lysate exhibited substantial clinical efficacy in ameliorating facial sensitive skin conditions, coupled with a high safety profile.

KEYWORDS panthenol, prebiotics, probiotics, sensitive skin, skin barrier function
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study 2024-11-26 00:00

Marta Arnal‑Forné1 · Tamara Molina‑García2 · María Ortega2 · Víctor Marcos‑Garcés2,3 · Pilar Molina4 · Antonio Ferrández‑Izquierdo1,2,5 · Pilar Sepulveda1,6,7 · Vicente Bodí2,3,6,8 · César Ríos‑Navarro1,2,6 · Amparo Ruiz‑Saurí1,2,6

Accepted: 10 June 2024 / Published online: 2 July 2024

© The Author(s) 2024

Abstract

Skin represents the main barrier against the external environment, but also plays a role in human relations, as one of the prime determinants of beauty, resulting in a high consumer demand for skincare-related pharmaceutical products. Given the importance of skin aging in both medical and social spheres, the present research aims to characterize microscopic changes in human skin composition due to intrinsic aging (as opposed to aging infuenced by external factors) via histological analysis of a photoprotected body region. Samples from 25 autopsies were taken from the periumbilical area and classifed into four age groups: group 1 (0–12 years), group 2 (13–25 years), group 3 (26–54 years), and group 4 (≥55 years). Diferent traditional histological (hematoxylin–eosin, Masson’s trichrome, orcein, toluidine, Alcian blue, and Feulgen reaction) and immunohistochemical (CK20, CD1a, Ki67, and CD31) stains were performed. A total of 1879 images photographed with a Leica DM3000 optical microscope were morphometrically analyzed using Image ProPlus 7.0 for further statistical analysis with GraphPad 9.0. Our results showed a reduction in epidermis thickness, interdigitation and mitotic indexes, while melanocyte count was raised. Papillary but not reticular dermis showed increased thickness with aging. Specifcally, in the papillary layer mast cells and glycosaminoglycans were expanded, whereas the reticular dermis displayed a diminution in glycosaminoglycans and elastic fbers. Moreover, total cellularity and vascularization of both dermises were diminished with aging. This morphometric analysis of photoprotected areas reveals that intrinsic aging signifcantly infuences human skin composition. This study paves the way for further research into the molecular basis underpinning these alterations, and into potential antiaging strategies.

Keywords Skin aging · Intrinsic aging · Morphometric analysis · Human biopsies

César Ríos-Navarro

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* Amparo Ruiz-Saurí 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

1 Department of Pathology, University of Valencia, Avda. Blasco Ibáñez 15. 46010, Valencia, Spain

2 Instituto de Investigación Sanitaria INCLIVA Biomedical Research Institute, Avda. Menéndez Pelayo 4acc,

46010 Valencia, Spain

3 Cardiology Department, Hospital Clínico Universitario, Valencia, Spain

4 Department of Pathology, Instituto de Medicina Legal y Ciencias Forenses, Valencia, Spain

5 Anatomic Pathology Department, Hospital Clínico Universitario, Valencia, Spain

6 Centro de Investigación Biomédica en Red (CIBER)-CV, Madrid, Spain

7 Regenerative Medicine and Heart Transplantation Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain

8 Department of Medicine, University of Valencia, Valencia, Spain
An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair 2024-11-25 00:00

Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5

1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea

2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea

4 UltraV Co., Ltd. R&D Center, Seoul, South Korea

5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea

Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

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Abstract

Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.

Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.

Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.

Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.

KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

同步报告病例1（第五回）：TurboHawk斑块旋切系统开通股浅动脉支架闭塞病例

同步报告病例2（第十一回）：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过

同步报告病例2（第十回）：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过

同步报告病例3（第七回）：一个家庭护理失败的案例，并“夹生足”的同步治疗经过

同步报告病例4（第八回）：没有最烂，只有更烂。一个危重足患者保脚经历

同步报告病例4（第七回）：没有最烂，只有更烂一个危重足患者保脚经历

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

同步报告病例1（第五回）：TurboHawk斑块旋切系统开通股浅动脉支架闭塞病例

同步报告病例2（第十一回）：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过

同步报告病例2（第十回）：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过

同步报告病例3（第七回）：一个家庭护理失败的案例，并“夹生足”的同步治疗经过

同步报告病例4（第八回）：没有最烂，只有更烂。一个危重足患者保脚经历

同步报告病例4（第七回）：没有最烂，只有更烂 一个危重足患者保脚经历

消息订阅

学术会议

伤口世界提示

同步报告病例4（第七回）：没有最烂，只有更烂一个危重足患者保脚经历