张震宇

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27 8月 2019

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Author : 伤口世界

擅长糖尿病足治疗广东药科大学附属第三医院内分泌科主任医师

Latest from 伤口世界

Valorisation of Winery By-Products: Revealing the Polyphenolic Profile of Grape Stems and Their Inhibitory Effects on Skin Aging-Enzymes for Cosmetic and Pharmaceutical Applications
A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries
Exploring Anti-Aging Effects of Topical Treatments for Actinic Keratosis
Tailoring biomaterials for skin anti-aging
Curcumin and EGCG combined formulation in nanostructured lipid carriers for anti-aging applications

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Valorisation of Winery By-Products: Revealing the Polyphenolic Profile of Grape Stems and Their Inhibitory Effects on Skin Aging-Enzymes for Cosmetic and Pharmaceutical Applications 2025-05-28 00:00

Rui Dias-Costa 1,* , Concepción Medrano-Padial 2 , Raquel Fernandes 1 , Raúl Domínguez-Perles 2 , Irene Gouvinhas 1 and Ana Novo Barros 1,*

1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.F.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (I.G.)

2 Laboratorio de Fitoquímica y Alimentos Saludables (LabFAS), Centro de Edafología y Biología Aplicada del Segura-Spanish Council for Scientific Research (EBAS-CSIC), University Campus of Espinardo 25, 30100 Murcia, Spain; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (C.M.-P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.D.-P.)

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.D.-C.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.N.B.)

Citation: Dias-Costa, R.; MedranoPadial, C.; Fernandes, R.; DomínguezPerles, R.; Gouvinhas, I.; Barros, A.N. Valorisation of Winery By-Products: Revealing the Polyphenolic Profile of Grape Stems and Their Inhibitory Effects on Skin Aging-Enzymes for Cosmetic and Pharmaceutical Applications. Molecules 2024, 29, 5437.

https://doi.org/10.3390/molecules 29225437

Academic Editor: Michael Jourdes

Received: 17 October 2024

Revised: 9 November 2024

Accepted: 15 November 2024

Published: 18 November 2024

Copyright: © 2024 by the authors.

Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Abstract: Grape (Vitis vinifera L.) stems, a by-product of winemaking, possess significant potential value due to their rich polyphenolic composition, which allows their exploitation for cosmetic and pharmaceutical applications. This presents a promising opportunity for valorisation aimed at developing innovative products with potential health-promoting effects. In this study, the polyphenolic profile of extracts from grape stems of seven white grape varieties was determined using spectrophotometric and chromatographic methods, specifically high-performance liquid chromatography coupled with a photodiode array detector and electrospray ionization multi-stage mass spectrometry (HPLCPDA-ESI-MSn), as well as on their ferric-reducing antioxidant power (FRAP) and radical scavenging capacity, using 2,2-diphenyl-1-picrylhydrazyl (DPPH• ) and 2,2′ -azino-bis(3-ethylbenzothiazoline-6- sulfonic acid (ABTS•+ ) radicals. This study also evaluated the anti-aging activity and skin depigmenting activity of these extracts. These findings revealed a diverse polyphenolic profile, encompassing proanthocyanidins and catechin derivatives (PCDs), phenolic acids, and flavonols. Among the varieties studied, ‘Códega do Larinho’ exhibited the highest concentrations of six distinct polyphenols and the highest total phenolic content. It also demonstrated the highest results for antioxidant capacity and elastase and tyrosinase inhibition. Pearson’s correlation analysis showed a significant positive correlation between certain PCDs with both FRAP and DPPH assays, as well as between the identified flavonols and anti-elastase activity. These results underscore the potential health benefits of grape stem extracts and emphasize the importance of their polyphenolic composition in enhancing antioxidant and anti-aging properties, thus supporting their application in different industries.

Keywords: grape stems; polyphenolic profile; antioxidant capacity; anti-aging; valorisation
A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries 2025-05-27 00:00

Yu-Dan Wang 1 , Lu-Sheng Han 1 , Gen-Yue Li 1 , Kai-Li Yang 1 , Yan-Long Shen 2 , Hao Zhang 3 , Jian-Feng Hou 4 and En-Peng Wang 1,*

1 Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y.-D.W.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (L.-S.H.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (G.-Y.L.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.-L.Y.)

2 College of Innovation and Entrepreneurship, Changchun University of Chinese Medicine, Changchun 130117, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

3 Institute of Special Animal and Plant Sciences CAAS, Changchun 130112, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

4 Shiqi Biological R&D Centre (Suzhou Industrial Park) Co., Ltd., Suzhou 215125, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 * Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Citation: Wang, Y.-D.; Han, L.-S.; Li, G.-Y.; Yang, K.-L.; Shen, Y.-L.; Zhang, H.; Hou, J.-F.; Wang, E.-P. A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries. Molecules 2024, 29, 4962. https:// doi.org/ 10.3390/molecules29204962

Academic Editors: Jurca Tünde and

Laura Gratiela Vicas

Received: 5 September 2024

Revised: 14 October 2024

Accepted: 18 October 2024

Published: 20 October 2024

Copyright: © 2024 by the authors.

Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)

Abstract: This study was conducted to investigate the differences in chemical composition between red (RGBs) and yellow ginseng berries (YGBs) and their whitening and anti-aging skincare effects. The differences in the chemical composition between RGB and YGB were analyzed by ultrahigh-performance liquid chromatography tandem quadrupole electrostatic field orbit trap mass spectrometry (UHPLC-Q-Exactive-MS/MS) combined with multivariate statistics. An aging model was established using UVB radiation induction, and the whitening and anti-aging effects of the two ginseng berries were verified in vitro and in vivo using cell biology (HaCaT and B16-F10 cells) and zebrafish model organisms. A total of 31 differential compounds, including saponins, flavonoids, phenolic acids, and other chemical constituents, were identified between the two groups. Superoxide dismutase (SOD) activity was more significantly increased (p < 0.05) and malondialdehyde (MDA) content was more significantly decreased (p < 0.01) in RGB more than YGB induced by UVB ultraviolet radiation. In terms of whitening effects, YGB was more effective in inhibiting the melanin content of B16-F10 cells (p < 0.01). The results of zebrafish experiments were consistent with those of in vitro experiments and cell biology experiments. The DCFH fluorescence staining results revealed that both ginseng berries were able to significantly reduce the level of reactive oxygen species (ROS) in zebrafish (p < 0.01). Comparison of chemical composition and skin care activities based on RGB and YGB can provide a theoretical basis for the deep development and utilization of ginseng berry resources.

Keywords: ginseng; ginseng berry; chemical composition; anti-aging; anti-UVB; anti-melanin; whitening
Exploring Anti-Aging Effects of Topical Treatments for Actinic Keratosis 2025-05-26 00:00

Federica Li Pomi 1 , Andrea d’Aloja 2 , Dario Valguarnera 2 , Mario Vaccaro 2 and Francesco Borgia 2,*

1 Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, 98125 Messina, Italy; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.d.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (D.V.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (M.V.) * Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Academic Editor: Vita Lesauskaite.

Received: 3 January 2025

Revised: 14 January 2025

Accepted: 22 January 2025

Published: 24 January 2025

Citation: Li Pomi, F.; d’Aloja, A.;

Valguarnera, D.; Vaccaro, M.; Borgia, F.

Exploring Anti–Aging Effects of Topical Treatments for Actinic Keratosis. Medicina 2025, 61, 207.

https://doi.org/10.3390/ medicina61020207

Copyright: © 2025 by the authors.

Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

(https://creativecommons.org/ licenses/by/4.0/)

Abstract: Background and Objectives: Actinic keratosis (AK) is a precancerous cutaneous lesion driven by chronic ultraviolet (UV) exposure, often coexisting with features of photoaging, such as wrinkles and pigmentary irregularities. Recent evidence suggests that treatments for AK may also counteract photoaging through shared molecular pathways, including oxidative stress and inflammation. This narrative review explores the dual benefits of AK therapies, highlighting their potential anti-aging and skin-lightening effects, and implications for improving skin appearance alongside lesion clearance. Materials and Methods: The literature was analyzed to assess the efficacy, mechanisms, and cosmetic outcomes of commonly used AK treatments, including topical agents (5-fluorouracil (5-FU), imiquimod, diclofenac, and tirbanibulin), and photodynamic therapy (PDT). Studies highlighting their effects on photoaged skin, collagen remodeling, pigmentation, and patient satisfaction were reviewed. Results: PDT emerged as the most validated treatment, demonstrating improved collagen synthesis, skin texture, and pigmentation. 5-FU showed remodeling of the dermal matrix and increased procollagen levels, but local skin reactions represent a major limitation. Imiquimod enhanced dermal fibroplasia and reduced solar elastosis, while diclofenac provided mild photodamage improvements with minimal adverse effects. Tirbanibulin showed promising aesthetic outcomes, including skin lightening and a reduction in mottled pigmentation, with favorable tolerability. Conclusions: AK therapies offer a dual-purpose strategy, addressing both precancerous lesions and cosmetic concerns associated with photoaging. While PDT remains the gold standard, emerging agents like tirbanibulin ointment exhibit substantial potential. Future research should focus on optimizing treatment protocols and evaluating long-term cosmetic outcomes to enhance patient satisfaction and compliance.

Keywords: actinic keratosis; anti–aging; oxidative stress; photodynamic therapy; skin aging; skin lightening; solar lentigo; tirbanibulin; 5–fluorouracil

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

张震宇

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张震宇

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