Mateo Ve´ lez-Fort,1,3 Lee Cossell,1,3 Laura Porta,1 Claudia Clopath,1,2 and Troy W. Margrie1,4,*
1 Sainsbury Wellcome Centre, University College London, London, UK
2 Bioengineering Department, Imperial College London, London, UK
3 These authors contributed equally
4 Lead contact
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https://doi.org/10.1016/j.cell.2025.01.032
SUMMARY
Knowing whether we are moving or something in the world is moving around us is possibly the most critical sensory discrimination we need to perform. How the brain and, in particular, the visual system solves this motion-source separation problem is not known. Here, we find that motor, vestibular, and visual motion signals are used by the mouse primary visual cortex (VISp) to differentially represent the same visual flow information according to whether the head is stationary or experiencing passive versus active translation. During locomotion, we find that running suppresses running-congruent translation input and that translation signals dominate VISp activity when running and translation speed become incongruent. This cross-modal interaction between the motor and vestibular systems was found throughout the cortex, indicating that running and translation signals provide a brain-wide egocentric reference frame for computing the internally generated and actual speed of self when moving through and sensing the external world.
擅长疾病 : 慢性创面修复,如压疮、糖尿病足、静脉性溃疡、放射性溃疡、开胸手术后切口不愈合、皮肤肿瘤、外伤后骨外露等。各种瘢痕及溃疡。
中华医学会烧伤、医学美容整形专业会员,海南省医学会烧伤整形专业委员会常委兼秘书,海南省医学会烧伤整形专业委员会主要发起人之一。 1988年海南大学医学部毕业,一直从事烧伤救治、创面修复、瘢痕整形的临床医疗工作和科研,为具有烧伤外科专业、整形外科专业资格的执业医师。
大面积危重烧伤救治,各种原因烧烫伤,皮肤瘢痕整形,各种难愈创面的治疗如慢性溃疡、外伤后皮肤软组织缺损、糖尿病足等。
长期从事美容、整形及烧伤专业的临床、教学及科研工作,尤其擅长于体表肿瘤的诊治、瘢痕防治、精于各类美容整形手术、烧伤治疗和创面处理等。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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