Alfredo E. Hoyos,MDD;Mauricio E. Perez Pachon,MDD; Matt Stefanelli,MD;Mariana Borras Osorio, MD; Justo Calderon Mendoza,MSc;Maria Paula Castiblanco,MD;Mateo Leon Machicado,MD;and Andres Pinzon Valero,MD
AbstractBackground: Despite the general safety of liposuction and fat grafting procedures,surgical-site infections (SSIs) remain a significant concern. These infections, ranging from minor to severe,can arise from various sources and pose a substantial burden. The overuse of antibiotics has led to increased antimicrobial resistance,highlighting the need for alternative infection prevention strategies like stabilized hypochlorous acid (s-HOCl). Objectives: The aim of the authors of this study is to evaluate the efficacy and safety of s-HOCl in preventing SSIs following liposculpture and other body contouring procedures. Methods: A prospective cohort study and matched control cohort were conducted at a single plastic surgery center in Bogota,Colombia (Dhara Clinic). Adult patients scheduled for liposculpture and fat grafting from January 2020 to December 2023 formed the intervention group,receiving s-HOCl as a washing solution for adipose grafts. A matched control cohort was drawn from patients who underwent similar procedures from January 2017 to December 2019 without s-HOCl. Data on demographics,surgical characteristics,and SSI outcomes were collected and analyzed. Results: A total of 1008 patients were included,with 502 in the s-HOCl group and 506 in the control group. The infection rate in the s-HOCl group was 0.2 per 100 grafted muscles, compared with 0.54 in the control group. Relative risk of SSIs in the s-HOCl group was 0.4,indicating a reduction in infection rates. The small absolute risk reduction of 0.59% underscores the clinical importance,considering SSIs, although rare,are severe and life-threatening events,with significant impact on outcomes and healthcare costs. A reduction in the severity of infection and the level of required treatment was also observed. Conclusions: s-HOCl demonstrated potential to reduce SSI risk following liposuction and fat grafting. This intervention offers a valuable alternative to antibiotics,effectively reducing infection rates and contributing to improved patient outcomes and public health in postantibiotic era.
王昳娜1,何振华1,周瑾1,孙晓芬2
1.绍兴文理学院元培学院,浙江 312000;2.浙江中医药大学附属第二医院
Research progress on the application of hypochlorous acid in wound care
WANG Yi'na,HE Zhenhua,ZHOU Jin,SUN Xiaofen
Shaoxing University,Yuanpei College,Zhejiang 312000 China
Keywords hypochlorous acid solution;wound;infection;bacterial biofilm;clinical application;review
摘要 介绍了次氯酸溶液的发展史、杀菌机制、特点、与其他伤口清洁消毒剂的比较、使用方法以及当前研究的不足,旨在为次氯酸
溶液在伤口治疗、护理中的应用提供依据。
关键词 次氯酸溶液;伤口;感染;细菌生物膜;临床应用;综述
擅长疾病:在烧伤、创伤后瘢痕整形、先天性畸形、面部及躯干美容等方面临床经验丰富,具有较强的解决本专业疑难病例的能力及显微外科手术能力。
擅长领域:(1)耳廓、乳房、阴茎、鼻部等体表器官再造(2)体表软组织肿瘤切除与美容修复(3)脂肪移植与面部年轻化(4)血管瘤、鲜红斑痣等激光美容
对烧伤外科、整形外科及美容外科有较深的造谐,擅长大面积严重烧伤的救治,唇腭裂修复、软组织缺损的修复及各类美容整形和再造整形手术,每年完成大小各类手术360余例。
从事整形外科近30年,留美多年,熟练掌握面部美容、除皱、乳房整形、脂肪抽吸等各类美容整形外科手术及各种非手术美容(如肉毒毒素A注射除皱等),对外生殖器整形与再造,两性畸形和易性症的手术治疗等有较深入研究。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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