Yu-Dan Wang 1 , Lu-Sheng Han 1 , Gen-Yue Li 1 , Kai-Li Yang 1 , Yan-Long Shen 2 , Hao Zhang 3 , Jian-Feng Hou 4 and En-Peng Wang 1,*
1 Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y.-D.W.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (L.-S.H.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (G.-Y.L.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.-L.Y.)
2 College of Innovation and Entrepreneurship, Changchun University of Chinese Medicine, Changchun 130117, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
3 Institute of Special Animal and Plant Sciences CAAS, Changchun 130112, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
4 Shiqi Biological R&D Centre (Suzhou Industrial Park) Co., Ltd., Suzhou 215125, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 * Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Citation: Wang, Y.-D.; Han, L.-S.; Li, G.-Y.; Yang, K.-L.; Shen, Y.-L.; Zhang, H.; Hou, J.-F.; Wang, E.-P. A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries. Molecules 2024, 29, 4962. https:// doi.org/ 10.3390/molecules29204962
Academic Editors: Jurca Tünde and
Laura Gratiela Vicas
Received: 5 September 2024
Revised: 14 October 2024
Accepted: 18 October 2024
Published: 20 October 2024
Copyright: © 2024 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)
Abstract: This study was conducted to investigate the differences in chemical composition between red (RGBs) and yellow ginseng berries (YGBs) and their whitening and anti-aging skincare effects. The differences in the chemical composition between RGB and YGB were analyzed by ultrahigh-performance liquid chromatography tandem quadrupole electrostatic field orbit trap mass spectrometry (UHPLC-Q-Exactive-MS/MS) combined with multivariate statistics. An aging model was established using UVB radiation induction, and the whitening and anti-aging effects of the two ginseng berries were verified in vitro and in vivo using cell biology (HaCaT and B16-F10 cells) and zebrafish model organisms. A total of 31 differential compounds, including saponins, flavonoids, phenolic acids, and other chemical constituents, were identified between the two groups. Superoxide dismutase (SOD) activity was more significantly increased (p < 0.05) and malondialdehyde (MDA) content was more significantly decreased (p < 0.01) in RGB more than YGB induced by UVB ultraviolet radiation. In terms of whitening effects, YGB was more effective in inhibiting the melanin content of B16-F10 cells (p < 0.01). The results of zebrafish experiments were consistent with those of in vitro experiments and cell biology experiments. The DCFH fluorescence staining results revealed that both ginseng berries were able to significantly reduce the level of reactive oxygen species (ROS) in zebrafish (p < 0.01). Comparison of chemical composition and skin care activities based on RGB and YGB can provide a theoretical basis for the deep development and utilization of ginseng berry resources.
Keywords: ginseng; ginseng berry; chemical composition; anti-aging; anti-UVB; anti-melanin; whitening
Xin Dan a,1 , Songjie Li a,1 , Han Chen a , Ping Xue a , Bo Liu a , Yikun Ju b , Lanjie Lei c,**,
Yang Li a,***, Xing Fan a,*
a Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China
b Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China
c Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, China
* Corresponding author.
** Corresponding author.
*** Corresponding author.
E-mail addresses: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (L. Lei), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y. Li), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (X. Fan).
1 These authors contributed equally to this work and shared the first authorship.
ARTICLE INFO
Keywords:
Biomaterials、Skin anti-aging、Plastic surgery、Tissue regeneration、Medical aesthetics
ABSTRACT
Skin aging is the phenomenon of degenerative changes in the structure and function of skin tissues over time and is manifested by a gradual loss of skin elasticity and firmness, an increased number of wrinkles, and hyperpigmentation. Skin anti-aging refers to a reduction in the skin aging phenomenon through medical cosmetic technologies. In recent years, new biomaterials have been continuously developed for improving the appearance of the skin through mechanical tissue filling, regulating collagen synthesis and degradation, inhibiting pigmentation, and repairing the skin barrier. This review summarizes the mechanisms associated with skin aging, describes the biomaterials that are commonly used in medical aesthetics and their possible modes of action, and discusses the application strategies of biomaterials in this area. Moreover, the synergistic effects of such biomaterials and other active ingredients, such as stem cells, exosomes, growth factors, and antioxidants, on tissue regeneration and anti-aging are evaluated. Finally, the possible challenges and development prospects of biomaterials in the field of anti-aging are discussed, and novel ideas for future innovations in this area are summarized.
1992年中山医科大学本科毕业，1999年获医学硕士学位，从事整形美容、癫痕治疗、创面修复临床工作近二十年。
教授，医学博士，博士研究生导师，硕士研究生导师。毕业于第三军医大学军医系，现任广州军区总医院整形外科主任兼全军激光整形中心主任。从事整形美容外科工作20余年，临床经验丰富，专科技术全面。
擅长：四肢血管损伤/周围神经损伤的外科治疗。带血管蒂组织瓣转位修复骨外露/钢板外露/组织缺损。先天性唇腭裂/先天性手畸形的整复。乳房缺陷的整形。手外伤I期/II期整复。血管瘤的外科治疗。
从事整形美容工作近30年，具有扎实的整形美容外科基础，擅长各种疤痕及溃疡创面的处理，血管瘤等浅表肿瘤的治疗；
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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