Clinical Evaluation of the Efficacy, Safety, and InUse Tolerability of a Diacnemide™-Containing Acne Kit (Facial Serum and Cleanser) Regimen for the Synergistic Management of Facial Acne in Adults

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26 2月 2025

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Author : 伤口世界

Clinical Evaluation of the Efficacy, Safety, and InUse Tolerability of a Diacnemide™-Containing Acne Kit (Facial Serum and Cleanser) Regimen for the Synergistic Management of Facial Acne in Adults

Maheshvari N. Patel , Nayan K. Patel , Apeksha M. Merja , Saurav Patnaik

1. Clinical Research, NovoBliss Research Private Limited, Ahmedabad, IND 2. Pharmacology, Swaminarayan University, Ahmedabad, IND 3. Dermatology, NovoBliss Research Private Limited, Ahmedabad, IND 4. Cosmetology, Anveya Living Private Limited, Gurgaon, IND

Corresponding author: Maheshvari N. Patel, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Review began 09/06/2024

Review ended 09/18/2024

Published 09/23/2024

© Copyright 2024

Patel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

DOI: 10.7759/cureus.69968

Categories: Dermatology

Keywords: dark spots, facial cleanser and serum, porphyrins, iga scoring, niacinamide, acne

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Open Access Original Article

How to cite this article

Patel M N, Patel N K, Merja A M, et al. (September 23, 2024) Clinical Evaluation of the Efficacy, Safety, and In-Use Tolerability of a Diacnemide™-Containing Acne Kit (Facial Serum and Cleanser) Regimen for the Synergistic Management of Facial Acne in Adults. Cureus 16(9): e69968.

DOI 10.7759/cureus.69968

This article is excerpted from the Cureus 2024 Sep 23;16(9): e69968. by Wound World.

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Exploring Anti-Aging Potential of Dendrobium Species and Novel Microemulsion Delivery of Dendrobium kentrophyllum Extract for Anti-Aging Effect 2025-06-06 00:00

Suradwadee Thungmungmee1 , Boonchoo Sritularak2 , Nakuntwalai Wisidsri1 , Nattakan Kanana3 , Nattika Nimmano3

1 Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand;

2 Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Science, Chulalongkorn University, Bangkok, Thailand;

3 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

Correspondence: Nattika Nimmano, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, Tel +66 0 2188399, Fax +66 0 2188401, Email 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Purpose: The study aimed to investigate in vitro anti-aging activities of 29 Dendrobium spp. and develop and characterize microemulsions (MEs) for topical application.

Methods: Antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), H2O2 scavenging, and ferric reducing antioxidant power (FRAP) assays. The anti-collagenase (MMP-1 and MMP-2) and anti-elastase activities were also evaluated.

Cytotoxicity and human intracellular reactive oxygen species (ROS) levels were determined using resazurin reduction and 2′,7′- dichlorofluorescin diacetate (DCFDA) assays, respectively. D. kentrophyllum extract-loaded microemulsion (DKME) was then prepared and optimized. The stability of DKME was studied using a heating-cooling cycle.

Results: D. kentrophyllum appeared to be the best candidate anti-aging agent because of its antioxidant, anti-collagenase, and antielastase activities. The extract was safe for human skin cells at a concentration of 6.25–100 μg/mL. It also decreased the intracellular ROS-induced ultraviolet B (UVB) irradiation compared to that in the control. DKME comprising Tween 80:ethanol (5:1), water, and isononyl isononanoate showed a suitable appearance, droplet size, polydisperse index, zeta potential, pH, and viscosity. This formulation demonstrated desirable physical and chemical stability, with non-cytotoxic effects.

Conclusion: DKME is considered a promising anti-aging product. However, an in vivo study of this optimized formulation might be evaluated in further study for anti-aging purposes.

Keywords: reactive oxygen species, anti-aging activities, Dendrobium kentrophyllum, microemulsion
Protective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies 2025-06-04 00:00

Magdalena Wójciak 1,* , Piotr Drozdowski 2,* , Agnieszka Skalska-Kami ´nska 1 , Martyna Zagórska-Dziok 3 , Aleksandra Ziemlewska 3 , Zofia Nizioł-Łukaszewska 3 and Małgorzata Latalska 4

1 Department of Analytical Chemistry, Medical University of Lublin, Chod´zki 4a, 20-093 Lublin, Poland; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Department of Plastic Surgery, Specialist Medical Centre, 57-320 Polanica-Zdrój, Poland

3 Department of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (M.Z.-D.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.Z.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Z.N.-Ł.)

4 Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-079 Lublin, Poland; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (M.W.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (P.D.)

Citation: Wójciak, M.; Drozdowski, P.; Skalska-Kami ´nska, A.; Zagórska Dziok, M.; Ziemlewska, A.; Nizioł- Łukaszewska, Z.; Latalska, M. Protective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies. Molecules 2024, 29, 5790. https://doi.org/10.3390/ molecules29235790

Academic Editors: José Basilio Heredia, Luis Angel CabanillasBojórquez and Marilyn

Shomara Criollo-Mendoza

Received: 1 November 2024

Revised: 1 December 2024

Accepted: 5 December 2024

Published: 7 December 2024

Abstract: Isoflavones are found in numerous plant species within the Leguminosae family; however, soy isoflavones are particularly significant in practice and have been extensively studied in recent years. The health-promoting potential of orally administered soy isoflavones is widely documented in the scientific literature, and many review articles have been developed to highlight their significance. However, it should be noted that soy-isoflavone-rich extracts and isolated soy isoflavones, such as genistein and daidzein, are also often applied topically as ingredients in many formulations, including face creams, tonics, and emulsions. New delivery systems are continuously being developed to enhance the skin permeability of isoflavones, thus improving their efficacy. In this context, their direct activity on skin cells is an important aspect of scientific research. The anti-inflammatory, protective, and antioxidant properties of isoflavones and soy extracts make them promising cosmetic ingredients with anti-aging potential because inflammation and the accumulation of reactive oxygen species (ROS) can lead to structural and functional changes in skin cells, accelerating the aging process. This review provides an overview of research on the impact of the application of soy isoflavone extract and soy-derived isoflavones on skin cells, with a focus on the documented molecular mechanisms underlying their effects. This study aims to offer essential insights to aid in the development of functional cosmetics and future clinical applications.

Keywords: phytoestrogens; topical application; genistein; daidzein; fibroblasts; keratinocytes; skin
Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage 2025-06-03 00:00

Minseo Kang 1,† , Somin Park 2,†, So-Ri Son 2 , Yedam Noh 2 , Dae Sik Jang 2,* and Sullim Lee 1,*

1 Department of Life Science, College of Bio-Nano Technology, Gachon University, Seongnam 13120, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.-R.S.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y.N.)

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (D.S.J.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.L.)

† These authors equally contributed to this work.

Abstract: Panax ginseng (Korean ginseng) is renowned for its health-promoting properties, attributed to its bioactive compounds, including saponins, polyphenols, and polysaccharides, which possess both antioxidant and anti-aging activities. This study investigated the anti-aging and antiinflammatory effects of compounds isolated from the hot water extract of fresh P. ginseng roots, evaluating their resistance to TNF-α/IFN-γ-induced skin cell damage. Among 14 compounds, ginsenoside Rf (compound 2) showed significant multi-target effects. In NHDFs, ginsenoside Rf and others effectively reduced intracellular ROS, demonstrating strong antioxidant properties. Additionally, they inhibited MMP-1 expression, a key enzyme in collagen degradation, and promoted pro-collagen Type I synthesis, countering the negative effects of TNF-α and supporting skin health. Further analysis showed that ginsenoside Rf reduced the secretion of inflammatory cytokines like IL-1β and IL-6, exhibiting anti-inflammatory effects. It also promoted the expression of crucial skin barrier proteins, including LOR, AQP3, FLG, and KRT1 in TNF-α/IFN-γ-stimulated NHEKs, enhancing skin hydration and structural integrity. These results suggest that compounds from P. ginseng roots, especially ginsenoside Rf, hold promise as skincare agents targeting skin aging and inflammation. Future research should further explore their mechanisms and optimize their applications in dermatological treatments.

Keywords: ginsenoside Rf; P. ginseng; anti-aging; anti-inflammatory; ROS; MMP-1; skin barrier; TNF-α/IFN-γ

Citation: Kang, M.; Park, S.; Son, S.-R.; Noh, Y.; Jang, D.S.; Lee, S. Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ- Induced Skin Cell Damage. Molecules 2024, 29, 5479. https://doi.org/ 10.3390/molecules29225479

Academic Editor: Enrique

Barrajón-Catalán

Received: 24 October 2024

Revised: 15 November 2024

Accepted: 18 November 2024

Published: 20 November 2024

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