Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin

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04 3月 2025

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Author : 伤口世界

Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin

Hiroyasu Iwahashi1 | Yoshihito Kawashima1 | Hitoshi Masaki2,3 | Atsushi Taga4,5

1Research Center, Maruzen Pharmaceuticals Co., Ltd., Hiroshima, Japan | 2Laboratory of Photoaging Research, School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan | 3Research Institute for Human Health Science, Konan University, Hyougo, Japan | 4Pathological and Biomolecule Analyses Laboratory, Faculty of Pharmacy, Kindai University, Osaka, Japan | 5Antiaging Center, Kindai University, Osaka, Japan

Correspondence: Hiroyasu Iwahashi (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 7 June 2024 | Revised: 7 January 2025 | Accepted: 7 January 2025

Funding: The authors received no specific funding for this work.

Keywords: Endo180 | Melissa officinalis | photoaging | type I collagen | wrinkle

This article is excerpted from the Photodermatology, Photoimmunology & Photomedicine, 2025 by Wound World.

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Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin 2025-03-04 00:00

Hiroyasu Iwahashi1 | Yoshihito Kawashima1 | Hitoshi Masaki2,3 | Atsushi Taga4,5

1Research Center, Maruzen Pharmaceuticals Co., Ltd., Hiroshima, Japan | 2Laboratory of Photoaging Research, School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan | 3Research Institute for Human Health Science, Konan University, Hyougo, Japan | 4Pathological and Biomolecule Analyses Laboratory, Faculty of Pharmacy, Kindai University, Osaka, Japan | 5Antiaging Center, Kindai University, Osaka, Japan

Correspondence: Hiroyasu Iwahashi (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 7 June 2024 | Revised: 7 January 2025 | Accepted: 7 January 2025

Funding: The authors received no specific funding for this work.

Keywords: Endo180 | Melissa officinalis | photoaging | type I collagen | wrinkle
A Dermocosmetic Balm Containing Vitamin B5, Madecassoside, and a Prebiotic Complex Significantly Improves Post Fractionated CO2 Laser Downtime Versus a Repairing Skin Care: Results of a Randomized Double Blind Intra-Individual Exploratory Study 2025-03-03 00:00

Jean-Michel Amici1 | Guénaelle Le Dantec2 | Ann' Laure Demessant2 | Catherine Queille-Roussel3 | Magali Procacci Babled3 |

Anne Claire Cathelineau3 | Alix Danoy4 | Solene Trevisan4 | Merete Haedersdal5,6

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.

1 Service de Dermatologie, Hôpital Saint André, Bordeaux, France | 2La Roche-Posay Laboratoire Dermatologique, Levallois-Perret, France | 3CPCAD, CHU Nice, Nice, France | 4Newtone Technologies–A QIMA Life Sciences Company, Lyon, France | 5Department of Dermatology, Copenhagen University Hospital, Copenhagen, Denmark | 6Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark

Correspondence: Ann' Laure Demessant (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 31 July 2024 | Accepted: 18 September 2024

Funding: This study was supported by La Roche-Posay Laboratoire Dermatologique, France.

Keywords: dermocosmetic | post-procedure | re-epithelization | superficial CO2 laser | vitamin B5
In vitro, ex vivo, instrumental and clinical evaluation of a topical cream on the signs of periorbital ageing 2025-02-28 00:00

Alexandra D'Arcangelis1 | Sayantani Goswami Chatterjee1 | Isabel Diaz2 | Sabine Guehenneux3 | Jin Namkoong1 | Joanna Wu1

1 Skin Research and Innovation, Global Personal Care and Skin Health R&D, Colgate-Palmolive Company, Piscataway, New Jersey, USA

2 Dermal Clinical Research, ColgatePalmolive Company, Piscataway, New Jersey, USA

3 Laboratoires Filorga, Paris, France

Correspondence

Alexandra D'Arcangelis, Skin Research and Innovation, Global Personal Care and Skin Health R&D, ColgatePalmolive Company, 909 River Rd, Piscataway, NJ 08855, USA.

Email: alexandra_d_darcangelis@ colpal.com

Abstract

Objective: Periorbital skin ageing signs are multidimensional, highly visible and a concern for many. We evaluated the potential efficacy of an eye cream to diminish these signs.

Methods: Biological markers associated with ageing, barrier function and homeostasis were analysed in vitro to determine the effects of topically applied eye cream, compared to those of a placebo using human skin tissue models and/or explants. Collagen IV, elastin and bone morphogenic protein 4 (BMP4) expression was investigated by immunohistochemical labelling, while filaggrin, kallikrein 7 (KLK7) and HB-EGF were evaluated by RT-qPCR. IL-1α and melanin levels in darkly pigmented skin models were also quantified. The protective effect of the cream on glycation was assessed by a non-enzymatic assay. Finally, the benefits of twice-daily applications of the eye cream for 56days were instrumentally and clinically evaluated on 33 women.

Results: Only the eye cream, not the placebo, stimulated collagen IV and BMP4 protein expression, as well as increased elastin fibre length. It also led to higher HB-EGF, filaggrin and KLK7 mRNA levels. The placebo and the eye cream did not induce changes in IL-1α and melanin levels, but both reduced non-enzymatic glycation. When assessing the in vivo effects of the cream, short-term results indicated skin hydration, transepidermal water loss (TEWL) and skin profilometry improvement within 15min. Instrumental evaluations of wrinkles showed a reduction after 7days, which was clinically perceivable after 28 or 56days. The eye-opening angle and eyelid sagging also improved after seven and 28days, respectively. Finally, dark circles became lighter within 7days (instrumental measurement) or 28days (clinical assessment).

Conclusion: The instrumental and clinical evaluations revealed that the eye cream reduced all periorbital ageing signs evaluated. Its effects are supported by the in vitro and ex vivo analyses of molecular markers.

KEYWORDS

cosmetic, hydration, periocular ageing, puffiness, wrinkles

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