Joachim W. Fluhr,1 Andrew F. Alexis,2 Anneke Andriessen,3 Olga L. Ferero Barrios,4 Peter Bjerring,5 Peter Foley,6 Michael H. Gold,7 Hashim Kaderbhai,8 and Chengfeng Zhang9

1 Institute of Allergology, Charite Universitatsmedizin, Berlin, Germany € ,

2 Weill Cornell Medical Medicine, New York, New York, USA, 3 Andriessen Consultants, Malden, The Netherlands, 4 Centro de Dermatologia, Porto Alegre, Brazil,

5 Department of Dermatology, Aalborg University Hospital, Aalborg, Denmark,

6 Skin Health Institute, Carlton, Vic., Australia, 7 Gold Skin Care Center, Vanderbilt University School of Nursing, Nashville, TX, USA, 8 Aga Khan University Hospital, Nairobi, Kenya; and 9 Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China

Keywords

xerosis; ceramide; moisturizers; mature skin; skincare.

Correspondence

Anneke Andriessen

Andriessen Consultants

Zwenkgras 25

6581RK

Malden

The Netherlands

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Conflict of interest: None.

Funding source: Joachim W. Fluhr, Andrew F. Alexis, Anneke Andriessen, Olga L. Ferero Barrios, Peter Bjerring, Michael H. Gold, Hashim Kaderbhai, and Chengfeng Zhang received support from CeraVe International for the research of this project and consultancy fees for attending the meeting.

Abstract

Xerosis is highly prevalent in the population aged over 50 years and substantially impacts quality of life due to the associated stigma, related pruritus, and potential sequelae. We propose that the term mature xerosis be used for subjects over 50 who suffer from age-related xerosis and replace senile xerosis to describe the phenomenon. The etiology of xerosis depends on genetic and environmental factors that affect stratum corneum hydration and skin barrier function. Skincare to restore barrier function is essential in xerosis treatment and is relevant for maintaining and preventing its progression. Many moisturizers and cleansers are available for xerosis; however, they are underutilized by patients with mature xerosis. A panel of eight global dermatologists reviewed the unique aspects of xerosis in mature skin and discussed the specific needs, relevance, and considerations for skincare selection to prevent, treat, and maintain skin with mature xerosis. The panel selected five statements based on evidence from a literature review and the panel’s clinical experience to provide clinical considerations and recommendations for dermatologists and other healthcare providers treating patients with mature xerosis. Increased recognition of the burden of xerosis in mature skin is warranted. Gentle cleansers and barrier-restoring ceramide-containing moisturizers are essential to xerosis management, reducing signs and symptoms of xerosis, including associated pruritus.