大湾区慢性创面医护康标准化体系建设联盟，《中国科技论文》体表外科卷编辑委员会，黄广涛1，吴 军1，郇京宁1，2
（1.深圳大学第一附属医院（深圳市第二人民医院）烧伤整形科，广东深圳518000；2.上海交通大学医学院附属瑞金医院烧伤整形与创面修复科，上海200011）
摘要：负压封闭引流技术（negative pressure wound therapy， NPWT）自2017年国内首部烧伤外科应用专家共识发布以来，其技术类型与临床应用范围均取得了显著拓展。特别是在促进各类急慢性创面愈合及预防外科手术部位感染方面，已累积了大量高质量循证证据。为整合国内外最新研究成果与临床实践经验，规范操作标准，提升治疗水平，国内创面修复相关多学科领域的专家共同撰写了本更新版共识。本共识汇聚了国内多位在创面相关的多学科领域的专家，结合国内外最新研究成果，遵循严谨的循证医学原则，采用系统综述方法，聚焦于NPWT的技术分类、适应症、参数优化及并发症处理等核心议题。工作小组系统检索了PubMed、Web of Science、IEEE Xplore及中国知网等数据库中2015—2025年相关文献，共获得791篇。经去重、筛选，并根据纳入标准（临床研究、随机对照试验、meta分析及相关共识等）最终纳入210篇文献进行证据综合与评价。本共识旨在为创面修复相关学科的临床医生提供基于最新证据、统一且可操作的治疗方案与技术规范。共识内容充分结合了我国临床实践的现状与需求，以期推动NPWT在国内的合理、规范及高效应用，最终惠及广大患者。
关键词：负压封闭引流技术；手术部位感染；创面修复；手术切口并发症
Tarik Zahra,b,y , Vijay K. Bodac,d,y , Jian Gee,f,y , Lexiang Yua,g , Zhongzhi Wuc,d , Jianwen Quee,f,h, *, Wei Lic,d, *, Li Qianga,g, *
a Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA
b Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY 10032, USA
c Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA
d Drug Discovery Center, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA
e Division of Digestive and Liver Diseases, Columbia University, New York, NY 10032, USA
f Center for Human Development, Columbia University, New York, NY 10027, USA
g Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
h Department of Medicine, Columbia University, New York, NY 10032, USA
*Corresponding authors.
E-mail addresses: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Jianwen Que), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Wei Li), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Li Qiang).
These authors made equal contributions to this work.
Peer review under the responsibility of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Received 22 October 2023; received in revised form 13 December 2023; accepted 5 January 2024
KEY WORDS Estrogen receptor b; Aging; Metabolism; Skin injury; Muscle metabolism; Small molecule conjugates; Regeneration; Adiposity
Abstract
Estrogen is imperative to mammalian reproductivity, metabolism, and aging. However, the hormone activating estrogen receptor (ERs) a can cause major safety concerns due to the enrichment of ERa in female tissues and certain malignancies. In contrast, ERb is more broadly expressed in metabolic tissues and the skin. Thus, it is desirable to generate selective ERb agonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERa activation. Here, we report the design and of small molecule conjugates containing selective non-steroid ERb agonists Gtx878 or genistein. Treatment of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity, visceral adipose integrity, skeletal muscle function, and skin health, with validation in vitro. We further uncovered the benefits of ERb conjugates in the skin using two inducible skin injury mouse models, showing increased skin basal cell proliferation, epidermal thickness, and wound healing. Therefore, our ERb-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health.
https://doi.org/10.1016/j.apsb.2024.01.014
2211-3835 ª 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese
Academy of Medical Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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