Medical ozone treatment for pain, fatigue, anxiety, and depression in cancer patients: a scoping review

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05 1月 2026

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Author : 伤口世界

Medical ozone treatment for pain, fatigue, anxiety, and depression in cancer patients: a scoping review

This article is excerpted from the《Frontiers in Psychology》by Wound World

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Antimicrobial Hypochlorous Wound Irrigation Solutions Demonstrate Lower Anti-biofilm Efficacy Against Bacterial Biofilm in a Complex in-vitro Human Plasma Biofilm Model (hpBIOM) Than Common Wound Antimicrobials
Narrowing the chromosome 22q11.2 locus duplicated in bladder exstrophyeepispadias complex
W. Hardy Hendren, III, M.D., A personal perspective
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Antimicrobial Hypochlorous Wound Irrigation Solutions Demonstrate Lower Anti-biofilm Efficacy Against Bacterial Biofilm in a Complex in-vitro Human Plasma Biofilm Model (hpBIOM) Than Common Wound Antimicrobials 2026-09-17 00:00

Julian-Dario Rembe¹*†, Lioba Huelsboemer²^†, Isabell Plattfaut², Manuela Besser² and Ewa K. Stuermer³

¹Department of Vascular and Endovascular Surgery, University Hospital Düsseldorf, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany,²Chair for Translational Wound Research, Centre for Biomedical Education and Research, Witten/Herdecke University, Witten, Germany, ³Department of Vascular Medicine, University Heart and Vascular Center Hamburg, Translational Wound Research, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

Biofilms pose a relevant factor for wound healing impairment in chronic wounds.With 78% of all chronic wounds being affected by biofilms, research in this area is of high priority, especially since data for evidence-based selection of appropriate antimicrobials and antiseptics is scarce.Therefore,the objective of this study was to evaluate the anti-biofilm efficacy of commercially available hypochlorous wound irrigation solutions compared to established antimicrobials.Using an innovative complex in-vitro human plasma biofilm model(hpBIOM),quantitative reduction of Pseudomonas aeruginosa,Staphylococcus aureus,and Methicillin-resistant S. aureus (MRSA) biofilms by three hypochlorous irrigation solutions[two polyhexanide (PHMB)irrigation solution and 0.1%octenidine-dihydrochloride/phenoxyethanol(OCT/PE).Efficacy was compared to a non-challenged planktonic approach,as well as with increased substance volume over a prolonged exposure (up to 72 h).Qualitative visualization of biofilms was performed by scanning electron microscopy (SEM). Both reference agents(OCT/PE and PHMB)induced significant biofilm reductions within 72 h,whereby high volume OCT/PE even managed complete eradication of P. aeruginosa and MRSA biofilms after72 h.The tested hypochlorous wound irrigation solutions achieved no relevant penetration and eradication of biofilms despite increased volume and exposure. Only 0.2% NaClO managed a low reduction under prolonged exposure.The results demonstrate that low-dosed hypochlorous wound irrigation solutions are significantly less effective than PHMB-based irrigation solution and OCT/PE, thus unsuitable for biofilm eradication on their own. The used complex hpBIOM thereby mimics the highly challenging clinical wound microenvironment, providing a more profound base for future clinical translation.

Keywords: wound infection, biofilm, antimicrobial, antiseptic, hypochlorous acid, human plasma bioflm model, wound irrigation, chronic wound
Narrowing the chromosome 22q11.2 locus duplicated in bladder exstrophyeepispadias complex 2026-09-16 00:00

Glenda M. Beaman ^a^,^b, Adrian S. Woolf ^c^,^d, Filipa M. Lopes ^c, Shuang Andrew Guo ^e^,^f^,^{g, J}. Robert Harkness ^a^,b, Raimondo M. Cervellione ^d, David Keene ^d, Imran Mushtaq ^h, Menna R. Clatworthy ^f^,^g^,^h, William G. Newman ^a^,b,*

Summary

Introduction

Bladder exstrophyeepispadias complex (BEEC) comprises a spectrum of anterior midline congenital malformations, involving the lower urinary tract. BEEC is usually sporadic, but families with more than one affected member have been reported, and a twin concordance study supported a genetic contribution to pathogenesis. Moreover, diverse chromosomal aberrations have been reported in a small subset of individuals with BEEC. The commonest are 22q11.2 microduplications, identiﬁed in approximately 3% of BEEC index cases.

Objectives

We aimed to reﬁne the chromosome 22q11.2 locus, and to determine whether the encompassed genes are expressed in normal developing and mature human urinary bladders.

Results

Using DNA from an individual with CBE, the 22q11.2 duplicated locus was reﬁned by identiﬁcation of a maternally inherited 314 kb duplication (chr22:21,147,293e21,461,017), as depicted in this image. Moreover, the eight protein coding genes within the locus were found to be expressed during normal developing and mature bladders. To determine whether duplications in any of these individual genes were associated with CBE, we undertook copy number analyses in 115 individuals with CBE without duplications of the whole locus. No duplications of individual genes were found.

Discussion

The current study has reﬁned the22q11.2locus associated with BEEC and has shown that the eight protein coding genes are expressed in human bladders both during antenatal development and postnatally. Nevertheless, the precise biological explanation as to why duplication of the phenocritical region of22q11 confers increased susceptibility to BEEC remains to be determined. The fact that individuals with CBE without duplications of the whole locus also lacked duplication of any of the individual genes suggests that in individuals with BEEC and duplication of the 22q11.2 locus altered dosage of more than one gene may be important in BEEC etiology.

Conclusions

The study has reﬁned the 22q11.2 locus associated with BEEC and has shown that the eight protein coding genes within this locus are expressed in human bladders.
W. Hardy Hendren, III, M.D., A personal perspective 2026-09-15 00:00

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

Medical ozone treatment for pain, fatigue, anxiety, and depression in cancer patients: a scoping review

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

Medical ozone treatment for pain, fatigue, anxiety, and depression in cancer patients: a scoping review

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