Wang Shuaishuai 1† , Zhu Tongtong1† , Wang Dapeng2 ,

Zhang Mingran1 , Wang Xukai 1 , Yu Yue1 , Dong Hengliang1 ,

Wu Guangzhi 1 * and Zhang Minglei 1 *

1 Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China,

2 Department of Orthopedics, Siping Central Hospital, Siping, China

EDITED BY

Xiaoyuan Li,

Northeast Normal University, China

REVIEWED BY

Fuzeng Ren,

Southern University of Science and

Technology, China

Gong Cheng,

Harvard University, United States

Ruogu Qi,

Nanjing University of Chinese Medicine,

China

*CORRESPONDENCE

Wu Guangzhi,

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Zhang Minglei,

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†

These authors have contributed equally to this work

SPECIALTY SECTION

This article was submitted to Biomaterials, a section of the journal

Frontiers in Bioengineering and Biotechnology

RECEIVED 27 October 2022

ACCEPTED 18 January 2023

PUBLISHED 30 January 2023

CITATION

Shuaishuai W, Tongtong Z, Dapeng W, Mingran Z, Xukai W, Yue Y, Hengliang D, Guangzhi W and Minglei Z (2023), Implantable biomedical materials for treatment of bone infection.

Front. Bioeng. Biotechnol. 11:1081446.

doi: 10.3389/fbioe.2023.1081446

COPYRIGHT

© 2023 Shuaishuai, Tongtong, Dapeng, Mingran, Xukai, Yue, Hengliang, Guangzhi and Minglei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. 

The treatment of bone infections has always been difficult. The emergence of drugresistant bacteria has led to a steady decline in the effectiveness of antibiotics. It is also especially important to fight bacterial infections while repairing bone deffects and cleaning up dead bacteria to prevent biofilm formation. The development of biomedical materials has provided us with a research direction to address this issue.

We aimed to review the current literature, and have summarized multifunctional antimicrobial materials that have long-lasting antimicrobial capabilities that promote angiogenesis, bone production, or “killing and releasing.” This review provides a comprehensive summary of the use of biomedical materials in the treatment of bone infections and a reference thereof, as well as encouragement to perform further research in this field.

KEYWORDS

biological materials, bone infection, multifunctional material, implantable material, treatment of bone infection, progress of infection treatment, multifunctionalization of materials