Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modes of Action, and Study Outcomes

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07 8月 2026

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Author : 伤口世界

本文转载于J Clin Aesthet Dermatol. 2018;11(11):36–39，不代表本网站赞同其观点和对其真实性负责，我们只作于阅读分享，非商业用途，如若侵权，请告知删除。

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Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modes of Action, and Study Outcomes 2026-08-07 00:00

本文转载于J Clin Aesthet Dermatol. 2018;11(11):36–39，不代表本网站赞同其观点和对其真实性负责，我们只作于阅读分享，非商业用途，如若侵权，请告知删除。
Effect of Stabilized Hypochlorous Acid on Re-epithelialization and Bacterial Bioburden in Acute Wounds: A Randomized Controlled Trial in Healthy Volunteers 2026-08-06 00:00

Ewa A. BURIAN¹, Lubna SABAH¹, Klaus KIRKETERP-MØLLER¹, Glenn GUNDERSEN² and Magnus S. ÅGREN^1,3,4

¹Department of Dermatology and Copenhagen Wound Healing Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark,
²SoftOx Solutions AS, Oslo, Norway, ³Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen, and ⁴Department of Clinical
Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting 2026-08-05 00:00

Yuta Tsujisaka,^1,2,5 Takeshi Hatani,^1,2,5 Chikako Okubo,¹ Ryo Ito,¹ Azuma Kimura,¹ Megumi Narita,¹

Kazuhisa Chonabayashi,^1,3 Shunsuke Funakoshi,^1,4 Antonio Lucena-Cacace,¹ Taro Toyoda,1 Kenji Osafune,¹

Takeshi Kimura,² Hirohide Saito,^{1, *} and Yoshinori Yoshida^{1,4, *}

¹Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan

²Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan

³Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan

⁴Takeda-CiRA Joint Program (T-CiRA), Fujisawa 251-0012, Japan

⁵These authors contributed equally

*Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (H.S.), 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y.Y.)

https://doi.org/10.1016/j.stemcr.2022.05.003

SUMMARY
For regenerative cell therapies using pluripotent stem cell (PSC)-derived cells, large quantities of purified cells are required. Magnetic-activated cell sorting (MACS) is a powerful approach to collect target antigen-positive cells; however, it remains a challenge to purify various cell types efficiently at large scale without using antibodies specific to the desired cell type. Here we develop a technology that combines microRNA (miRNA)-responsive mRNA switch (miR-switch) with MACS (miR-switch-MACS) to purify large amounts of PSC-derived cells rapidly and effectively. We designed miR-switches that detect specific miRNAs expressed in target cells and controlled the translation of a CD4-coding transgene as a selection marker for MACS. For the large-scale purification of induced PSC-derived cardiomyocytes (iPSC-CMs), we transferred miR-208a-CD4 switch-MACS and obtained purified iPSC-CMs efficiently. Moreover, miR-375-CD4 switch-MACS highly purified pancreatic insulin-producing cells and their progenitors expressing Chromogranin A. Overall, the miR-switch-MACS method can efficiently purify target PSC-derived cells for cell replacement therapy.

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modes of Action, and Study Outcomes

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modes of Action, and Study Outcomes

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