漫画科普│什么叫介入治疗？介入医生是做什么的？

字号 + –

03 9月 2019

1
2
3
4
5

Author : 伤口世界

原创：中诺医疗

997 Views

伤口世界

电子邮件地址该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Latest from 伤口世界

Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage
Valorisation of Winery By-Products: Revealing the Polyphenolic Profile of Grape Stems and Their Inhibitory Effects on Skin Aging-Enzymes for Cosmetic and Pharmaceutical Applications
A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries
Exploring Anti-Aging Effects of Topical Treatments for Actinic Keratosis
Tailoring biomaterials for skin anti-aging

K2 Content

Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage 2025-06-03 00:00

Minseo Kang 1,† , Somin Park 2,†, So-Ri Son 2 , Yedam Noh 2 , Dae Sik Jang 2,* and Sullim Lee 1,*

1 Department of Life Science, College of Bio-Nano Technology, Gachon University, Seongnam 13120, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.-R.S.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y.N.)

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (D.S.J.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.L.)

† These authors equally contributed to this work.

Abstract: Panax ginseng (Korean ginseng) is renowned for its health-promoting properties, attributed to its bioactive compounds, including saponins, polyphenols, and polysaccharides, which possess both antioxidant and anti-aging activities. This study investigated the anti-aging and antiinflammatory effects of compounds isolated from the hot water extract of fresh P. ginseng roots, evaluating their resistance to TNF-α/IFN-γ-induced skin cell damage. Among 14 compounds, ginsenoside Rf (compound 2) showed significant multi-target effects. In NHDFs, ginsenoside Rf and others effectively reduced intracellular ROS, demonstrating strong antioxidant properties. Additionally, they inhibited MMP-1 expression, a key enzyme in collagen degradation, and promoted pro-collagen Type I synthesis, countering the negative effects of TNF-α and supporting skin health. Further analysis showed that ginsenoside Rf reduced the secretion of inflammatory cytokines like IL-1β and IL-6, exhibiting anti-inflammatory effects. It also promoted the expression of crucial skin barrier proteins, including LOR, AQP3, FLG, and KRT1 in TNF-α/IFN-γ-stimulated NHEKs, enhancing skin hydration and structural integrity. These results suggest that compounds from P. ginseng roots, especially ginsenoside Rf, hold promise as skincare agents targeting skin aging and inflammation. Future research should further explore their mechanisms and optimize their applications in dermatological treatments.

Keywords: ginsenoside Rf; P. ginseng; anti-aging; anti-inflammatory; ROS; MMP-1; skin barrier; TNF-α/IFN-γ

Citation: Kang, M.; Park, S.; Son, S.-R.; Noh, Y.; Jang, D.S.; Lee, S. Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ- Induced Skin Cell Damage. Molecules 2024, 29, 5479. https://doi.org/ 10.3390/molecules29225479

Academic Editor: Enrique

Barrajón-Catalán

Received: 24 October 2024

Revised: 15 November 2024

Accepted: 18 November 2024

Published: 20 November 2024
Valorisation of Winery By-Products: Revealing the Polyphenolic Profile of Grape Stems and Their Inhibitory Effects on Skin Aging-Enzymes for Cosmetic and Pharmaceutical Applications 2025-05-28 00:00

Rui Dias-Costa 1,* , Concepción Medrano-Padial 2 , Raquel Fernandes 1 , Raúl Domínguez-Perles 2 , Irene Gouvinhas 1 and Ana Novo Barros 1,*

1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.F.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (I.G.)

2 Laboratorio de Fitoquímica y Alimentos Saludables (LabFAS), Centro de Edafología y Biología Aplicada del Segura-Spanish Council for Scientific Research (EBAS-CSIC), University Campus of Espinardo 25, 30100 Murcia, Spain; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (C.M.-P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.D.-P.)

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.D.-C.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.N.B.)

Citation: Dias-Costa, R.; MedranoPadial, C.; Fernandes, R.; DomínguezPerles, R.; Gouvinhas, I.; Barros, A.N. Valorisation of Winery By-Products: Revealing the Polyphenolic Profile of Grape Stems and Their Inhibitory Effects on Skin Aging-Enzymes for Cosmetic and Pharmaceutical Applications. Molecules 2024, 29, 5437.

https://doi.org/10.3390/molecules 29225437

Academic Editor: Michael Jourdes

Received: 17 October 2024

Revised: 9 November 2024

Accepted: 15 November 2024

Published: 18 November 2024

Copyright: © 2024 by the authors.

Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Abstract: Grape (Vitis vinifera L.) stems, a by-product of winemaking, possess significant potential value due to their rich polyphenolic composition, which allows their exploitation for cosmetic and pharmaceutical applications. This presents a promising opportunity for valorisation aimed at developing innovative products with potential health-promoting effects. In this study, the polyphenolic profile of extracts from grape stems of seven white grape varieties was determined using spectrophotometric and chromatographic methods, specifically high-performance liquid chromatography coupled with a photodiode array detector and electrospray ionization multi-stage mass spectrometry (HPLCPDA-ESI-MSn), as well as on their ferric-reducing antioxidant power (FRAP) and radical scavenging capacity, using 2,2-diphenyl-1-picrylhydrazyl (DPPH• ) and 2,2′ -azino-bis(3-ethylbenzothiazoline-6- sulfonic acid (ABTS•+ ) radicals. This study also evaluated the anti-aging activity and skin depigmenting activity of these extracts. These findings revealed a diverse polyphenolic profile, encompassing proanthocyanidins and catechin derivatives (PCDs), phenolic acids, and flavonols. Among the varieties studied, ‘Códega do Larinho’ exhibited the highest concentrations of six distinct polyphenols and the highest total phenolic content. It also demonstrated the highest results for antioxidant capacity and elastase and tyrosinase inhibition. Pearson’s correlation analysis showed a significant positive correlation between certain PCDs with both FRAP and DPPH assays, as well as between the identified flavonols and anti-elastase activity. These results underscore the potential health benefits of grape stem extracts and emphasize the importance of their polyphenolic composition in enhancing antioxidant and anti-aging properties, thus supporting their application in different industries.

Keywords: grape stems; polyphenolic profile; antioxidant capacity; anti-aging; valorisation
A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries 2025-05-27 00:00

Yu-Dan Wang 1 , Lu-Sheng Han 1 , Gen-Yue Li 1 , Kai-Li Yang 1 , Yan-Long Shen 2 , Hao Zhang 3 , Jian-Feng Hou 4 and En-Peng Wang 1,*

1 Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y.-D.W.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (L.-S.H.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (G.-Y.L.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.-L.Y.)

2 College of Innovation and Entrepreneurship, Changchun University of Chinese Medicine, Changchun 130117, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

3 Institute of Special Animal and Plant Sciences CAAS, Changchun 130112, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

4 Shiqi Biological R&D Centre (Suzhou Industrial Park) Co., Ltd., Suzhou 215125, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 * Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Citation: Wang, Y.-D.; Han, L.-S.; Li, G.-Y.; Yang, K.-L.; Shen, Y.-L.; Zhang, H.; Hou, J.-F.; Wang, E.-P. A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries. Molecules 2024, 29, 4962. https:// doi.org/ 10.3390/molecules29204962

Academic Editors: Jurca Tünde and

Laura Gratiela Vicas

Received: 5 September 2024

Revised: 14 October 2024

Accepted: 18 October 2024

Published: 20 October 2024

Copyright: © 2024 by the authors.

Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)

Abstract: This study was conducted to investigate the differences in chemical composition between red (RGBs) and yellow ginseng berries (YGBs) and their whitening and anti-aging skincare effects. The differences in the chemical composition between RGB and YGB were analyzed by ultrahigh-performance liquid chromatography tandem quadrupole electrostatic field orbit trap mass spectrometry (UHPLC-Q-Exactive-MS/MS) combined with multivariate statistics. An aging model was established using UVB radiation induction, and the whitening and anti-aging effects of the two ginseng berries were verified in vitro and in vivo using cell biology (HaCaT and B16-F10 cells) and zebrafish model organisms. A total of 31 differential compounds, including saponins, flavonoids, phenolic acids, and other chemical constituents, were identified between the two groups. Superoxide dismutase (SOD) activity was more significantly increased (p < 0.05) and malondialdehyde (MDA) content was more significantly decreased (p < 0.01) in RGB more than YGB induced by UVB ultraviolet radiation. In terms of whitening effects, YGB was more effective in inhibiting the melanin content of B16-F10 cells (p < 0.01). The results of zebrafish experiments were consistent with those of in vitro experiments and cell biology experiments. The DCFH fluorescence staining results revealed that both ginseng berries were able to significantly reduce the level of reactive oxygen species (ROS) in zebrafish (p < 0.01). Comparison of chemical composition and skin care activities based on RGB and YGB can provide a theoretical basis for the deep development and utilization of ginseng berry resources.

Keywords: ginseng; ginseng berry; chemical composition; anti-aging; anti-UVB; anti-melanin; whitening

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

漫画科普│什么叫介入治疗？介入医生是做什么的？

伤口世界

Latest from 伤口世界

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

漫画科普│什么叫介入治疗？介入医生是做什么的？

伤口世界

Latest from 伤口世界

消息订阅

学术会议

伤口世界提示