痛风患者如何选择饮食疗法？

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12 10月 2019

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Author : 伤口世界

原创：卢魁

痛风之痛:
尿酸盐在体内大量沉积形成结晶，体表、手脚关节部位会慢慢长出痛风石，时间长了会导致关节破坏、关节畸形，影响正常功能。尿酸盐长期沉积在肾脏，会引发痛风性肾病，严重的甚至导致尿毒症。

痛风患者还常伴发有高脂血血症、高血压、糖尿病及冠心病。痛风久治不愈、反复发作也会形成慢性伤口。一般人正常膳食每天摄人嘌呤600~1000毫克，痛风急性发作期摄人量应控制在150 毫克以内，缓解期也应遵循低嘌呤饮食。
食物嘌呤含量参考
嘌呤含量> 150 毫克/100克。动物内脏：肝、肾、脑、脾、肠；部分水产：带鱼、鲶鱼、鲢鱼、沙丁鱼、凤尾鱼、基围虾等。肉汤、鱼汤、海鲜火锅汤。
嘌呤含量在75-150毫克|100克。猪、牛、羊肉、鸡鸭等；鲈鱼、鲤鱼、鲫鱼、草鱼；螃蟹；黑豆、黄豆、绿豆等。
嘌呤含量在30-75毫克/100克。菠菜、芦笋、毛豆、豌豆、三文鱼、金枪鱼及豆浆、豆干、豆皮、腐竹、豆腐等。
嘌呤含量< 30毫克/100克。大白菜、土豆、芋头、白薯、木薯、番茄、茄子、冬瓜。部分杂粮：小米、荞麦、燕麦；葡萄、苹果、草莓；米饭、馒头等。

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Anxiety, social responsiveness, and grit among patients with KCNJ11- related neonatal diabetes compared to unaffected siblings 2026-05-15 00:00

Jui M. Desai1 · Lisa R. Letourneau-Freiberg1 · Kristen E. Wroblewski2 · Megan N. Scott3 · Michael E. Msall4 · Siri Atma W. Greeley1,4

Received: 27 February 2025 / Accepted: 4 October 2025 / Published online: 27 January 2026 © The Author(s) 2026

Abstract

Aims Neonatal diabetes mellitus (NDM) occurs before 6–12 months of age and is commonly caused by activating mutations in KCNJ11 (KCNJ11-NDM) or ABCC8. Because of brain expression of these mutant ATP-dependent potassium channels, a spectrum of divergent neurodevelopmental difficulties have been described, including developmental delay, epilepsy, and neonatal diabetes (DEND). However, information on anxiety, social responsiveness, and grit is limited.

Methods Individuals with KCNJ11-NDM (N= 12) and their unaffected siblings (N=12) were recruited through the Uni-versity of Chicago Monogenic Diabetes Registry and participants or their parent/caregiver completedthe Screen for Adult/ Child Anxiety Related Disorder (SCAARED/SCARED), the Social Responsiveness Scale, Second Edition (SRS-2), and the Grit Scale.

Results Mean SRS-2 scores were significantly different between KCNJ11-NDM and sibling controls (P= <0.001 ), with 7/10 affected participants, and 0 /11 siblings, having scores suggestive of autism spectrum disorder (ASD). Differences in anxiety (P=0.69) and grit (P=0.46) were not significant when compared to sibling controls; however, 58% (7/12) of KCNJ11-NDM participants and 40% (4/10) of sibling controls had scores indicating an anxiety disorder by either self- or parent-report.

Conclusions Our results agree with previous studies suggesting significant difficulties with social functioning in KCNJ11- NDM, with 7/10 participants having scores suggestive of ASD, strongly reinforcing the need for early neurodevelopmental screening to allow for prompt support. Our report adds to the knowledge of this population in finding robust grit scores but with a high level of anxiety in both KCNJ11-NDM and unaffected siblings. Although families affected by KCNJ11-NDM may have a high risk of anxiety disorders, it is encouraging that affected and unaffected children exhibit robust self-resiliency that will help support functioning through the challenges of life. Study of additional individuals will help to clarify specific challenges, long-term outcomes, and best approaches for monitoring and support.

Keywords Diabetes mellitus · Potassium channels · Brain · Anxiety · Resilience · Genetics
A high-quality RNA-yielding protocol for laser capture microdissection of transplanted stem cell-derived Islets of Langerhans 2026-05-14 00:00

Daniel Norman1 · Joey Lau1

Received: 22 March 2025 / Accepted: 18 January 2026 © The Author(s) 2026

Abstract

Background Laser capture microdissection (LCM) followed by RNA-sequencing is a powerful, widely applicable tool to analyze the transcriptome in regions of a tissue. Protocols for LCM of transplanted islets of Langerhans, particularly stem cell-derived islets (SC-islets) that have evaluated RNA quality, are lacking. This study demonstrates a robust protocol for LCM of SC-islets in multiple organ sites, generating high quality RNA.

Method SC-islets were transplanted to five organ sites in immunodeficient NOG-mice. Graft-containing organs were then sectioned, fixed in 75% ethanol, stained with the alcohol-based stain cresyl violet, and dehydrated before performing LCM. RNA was then extracted, and quality control was performed.

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Honghong Zhang¹ · Changlin Zhai¹ · Huilin Hu¹ · Gang Qian¹ · Menghui Mao¹

Received: 1 November 2025 / Accepted: 18 January 2026©The Author(s) 2026

Abstract

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Conclusion Patients with DM complicated by MI exhibit distinct gut microbial compositions and functional gene signatures compared with patients with DM alone. These microbiome-based markers may contribute to early risk stratification and provide potential targets for microbiota-focused interventions to mitigate MI risk in patients with diabetes.

Keywords Gut microbiome · Type 2 diabetes mellitus · Myocardial infarction · Metagenomics

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长