The intriguing eﬀects of time to glycemic goal in newly

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16 10月 2019

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Author : 伤口世界

流星中山二院糖尿病足中心

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伤口世界

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Protective Effects of Sesame Glycoproteins on Ultraviolet-Induced Skin Aging: In Vitro and In Vivo Studies
Effects of Hypochlorous Acid Solutions on Venous Leg Ulcers (VLU): Experience With 1249 VLUs in 897 Patients
Betaine–salicylic acid cocrystal for enhanced skincare and acne treatment†
Treatment effects of two pharmaceutical skin care creams for xerotic feet among persons with diabetes: Rationale and design of a two-armed double blind randomized controlled trial
Enhancement of skin regeneration through activation of TGF-β/SMAD signaling pathway by Panax ginseng meyer non-edible callus-derived extracellular vesicles

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Protective Effects of Sesame Glycoproteins on Ultraviolet-Induced Skin Aging: In Vitro and In Vivo Studies 2025-04-08 00:00

Kyung Kyu Baik 1,†, Woo-Yong Song 2,†, Dong Keun Song 1 , Jaehyeok Yun 1 , Ji Hwan Jang 1 , Jae Young Oh 1 , Mi-Jin Lee 2 , Eunjandi Go 2 , Kyong Jin Lee 2 , Eunmiri Roh 3 and Jong-Eun Kim 1,*

1 Department of Food Science and Technology, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea; bkk770@naver.com (K.K.B.); ehdrms0210@naver.com (D.K.S.); qweasd126@naver.com (J.Y.); c91084@naver.com (J.H.J.); jaeyong605@naver.com (J.Y.O.)

2 CNABIOTECH Co., Ltd., Cheongju-si 28106, Republic of Korea; sjousong@naver.com (W.-Y.S.); shuduc@hanmail.net (M.-J.L.); kejd9686@gmail.com (E.G.); jincrow@daum.net (K.J.L.)

3 Department of Cosmetic Science, Kwangju Women’s University, Gwangju 62396, Republic of Korea; roheunmiri@kwu.ac.kr

* Correspondence: jekim14@ut.ac.kr; Tel.: +82-43-820-5245; Fax: +82-43-820-5240

† These authors contributed equally to this work

Abstract: Background/Objectives: Ultraviolet (UV) radiation is a primary factor in skin photoaging, leading to wrinkles, reduced elasticity, and pigmentation changes due to damage to cellular DNA, proteins, and lipids. Glycoproteins from sesame cake (SPE) have potential protective effects against UV-induced skin aging. This study investigated the anti-photoaging effects of SPE on UV-induced damage in human keratinocyte HaCaT cells and SKH-1 hairless mice. Methods: SPE was evaluated for its ability to mitigate UV-induced damage in HaCaT cells by assessing MMP-1 protein and mRNA expression levels, as well as the activity of transcription factors AP-1 and NF-κB. The phosphorylation of AKT and MAPK pathways was also analyzed. In vivo, SKH-1 hairless mice were exposed to UV radiation, and the effects of SPE on wrinkle formation and skin structure were assessed by measuring wrinkle length, area, and volume. Results: SPE significantly inhibited UV-induced MMP-1 protein and mRNA expression in HaCaT cells, indicating suppression of AP-1 and NF-κB transcription factors involved in MMP-1 production. Additionally, SPE reduced UV-induced phosphorylation of AKT and MAPK pathways. In SKH-1 hairless mice, SPE treatment led to significant reductions in wrinkle length, area, and volume, preserving skin structure in UV-exposed mice. Conclusions: The findings demonstrate that SPE has protective effects against UV-induced photoaging by inhibiting key molecular pathways associated with skin aging. SPE shows promise as a natural anti-photoaging agent, providing a foundation for future skincare product development. Further studies are warranted to explore the molecular mechanisms in detail and to validate these effects through clinical trials.

Keywords: sesame glycoproteins; ultraviolet; skin; aging
Effects of Hypochlorous Acid Solutions on Venous Leg Ulcers (VLU): Experience With 1249 VLUs in 897 Patients 2025-04-07 00:00

Cheryl M. Bongiovanni, PhD, RVT, CWS, FASA, FACCWSa,b, *

a Wound Clinics and Vascular Laboratories, Lake Health District, Lake District Hospital, 700 South J Street, Lakeview, OR 97630, USA; and

b Lake Wound Clinic – Klamath Falls, LLC, 2301 B Mountain View Boulevard, Klamath Falls, OR 97601, USA

KEYWORDS: Venous leg ulcer (VLU); Hypochlorous acid; Multidrug resistant infection
Betaine–salicylic acid cocrystal for enhanced skincare and acne treatment† 2025-04-03 00:00

Zhenyuan Wang,ab Mi Wang, *a Qingsheng Tao,c Yufei Li, d Hao Wang,a Mei Zhang,c Xueli Liuc and Jiaheng Zhang *a

a Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China. E-mail: wangmi@hit.edu.cn, zhangjiaheng@hit.edu.cn

b Shenzhen Shinehigh Innovation Technology Co., Ltd., Shenzhen 518055, China

c Advanced Research, L'Oreal Research & Innovation China, Shanghai 201206, China

d The Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao 999078, China

† Electronic supplementary information (ESI) available. CCDC 2101906. For ESI

and crystallographic data in CIF or other electronic format see DOI: https://doi.

org/10.1039/d5md00001g

Salicylic acid (SA) is a natural lipophilic active ingredient commonly used in cosmetics and skin disease treatments, offering benefits such as exfoliation, anti-inflammation effects, antibacterial properties, oil control, and acne alleviation. However, its poor water solubility, low bioavailability, and potential side effects, such as allergies, irritation, and dryness, hinder its widespread application. In this study, we prepared a betaine–salicylic acid (BeSA) cocrystal and systematically characterized its crystal structure, biological activity, and clinical efficacy. The results showed that BeSA has significantly lower irritancy and cytotoxicity than SA, but exhibits excellent anti-inflammatory and antioxidant properties as well as high moisturizing and anti-acne efficacy, making it a potential alternative to SA. Further, quantum chemical calculations and molecular docking simulations were conducted to investigate the intrinsic mechanisms underlying the excellent bioactivity of BeSA cocrystals. This study introduces an innovative solution for safer and more effective skincare formulations based on SA and offers theoretical guidance regarding material engineering and further material optimization, which has crucial implications for both industry and academia.

Received 1st January 2025,

Accepted 4th February 2025

DOI: 10.1039/d5md00001g rsc.li/medchem

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