伤口世界

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星期一, 09 9月 2019

破伤风，伤口工作中需要知道的知识点儿（上篇基础理论）

文章转自公众号：迷途小羔羊9527

这段时间准备给学生讲课，其中一个内容就是破伤风。这个病在11年前实习的时候管过一例（暴露年龄了），之后就没接触过。快要讲课了，心里有点虚，找资料来恶补一轮，也就顺便更新一下，就当预讲课。

星期一, 09 9月 2019

关爱癌性伤口患者，努力让他们活得更有尊严

原创：胡海涛负压引流与创面修复

癌性伤口，给患者的伤痛难于安抚，他们活在癌症与伤口疼痛双重压力下，连正常洗澡权力可能被剥夺了，是苦不堪言。

过去处理过颈部巨大癌性溃疡、会阴部巨大溃疡、腹部癌性肠瘘，虽然没能把他们治愈，但是通过专业处理，他们在离世之前获得了最后的尊严。

星期一, 09 9月 2019

7天治愈颈部脓肿——从切开到愈合！

原创：胡海涛负压引流与创面修复

女性患者，29岁，因为害怕手术，颈部包块肿痛1月，一直保守治疗，超声示左侧颈前区脓肿，一周后需要出国旅游，提出‘一周可以治愈吗’？

星期一, 09 9月 2019

感染性皮脂腺囊肿的负压引流经验分享

原创：胡海涛负压引流与创面修复

前言：皮脂腺囊肿，是一个常见疾病，如果不痛不痒时治疗，直接切除它，一期缝合，一周可以痊愈！感染后就医，是一个麻烦疾病，如果合并糖尿病，更是雪上加霜，痛苦持续少则半个月，多着一个月！

星期一, 09 9月 2019

纱布致医疗事故敲响警钟----警惕伤口窦道遗物残留！

原创：胡海涛负压引流与创面修复

攀枝花市卫生计生委，依据《中华人民共和国执业医师法》《医疗事故处理条例》等相关法律法规，责令西区卫生计生局对承担主要责任的攀枝花宏实医院及其涉责医务人员作出处理：吊销攀枝花宏实医院《医疗机构执业许可证》；吊销主持术前讨论和手术主刀的医生文莉琼《医师执业证书》；吊销器械护士苏阿芹《护士执业证书》；吊销巡回护士周燕《护士执业证书》；暂停参与术前讨论的医生胡晓峰执业活动。

伤口爱好者，如何避免，如何避免不发生在自己身上?

星期一, 09 9月 2019

纱布做负压引流材料，治愈的一例骶尾部褥疮

原创：无限di渴望负压引流与创面修复

套装VSD价格昂贵:让很多患者望而却步，同时也让很多医护人员退避三舍！

K2 Content

An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair 2024-11-25 00:00

Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5

1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea

2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea

4 UltraV Co., Ltd. R&D Center, Seoul, South Korea

5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea

Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 and 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.

Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.

Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.

Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.

KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200
异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

破伤风，伤口工作中需要知道的知识点儿（上篇基础理论）

关爱癌性伤口患者，努力让他们活得更有尊严

7天治愈颈部脓肿——从切开到愈合！

感染性皮脂腺囊肿的负压引流经验分享

纱布致医疗事故敲响警钟----警惕伤口窦道遗物残留！

纱布做负压引流材料，治愈的一例骶尾部褥疮

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

破伤风，伤口工作中需要知道的知识点儿（上篇基础理论）

关爱癌性伤口患者，努力让他们活得更有尊严

7天治愈颈部脓肿——从切开到愈合！

感染性皮脂腺囊肿的负压引流经验分享

纱布致医疗事故敲响警钟----警惕伤口窦道遗物残留！

纱布做负压引流材料，治愈的一例骶尾部褥疮

消息订阅

学术会议

伤口世界提示