伤口世界

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星期五, 06 9月 2019

10个成年人中就有一个得肾病，生活中常被忽视的6个伤肾小细节，特别是第6个！

中山一院中诺医疗

中华医学会肾脏病学分会主任委员、中山一院肾内科学科带头人余学清教授指出，慢性肾脏病在我国成年人群中的发病率为10.8%，意味着每十个成年人就有一名是慢性肾脏病患者，这个比例在广东则更高。

星期五, 06 9月 2019

北大医院：糖尿病有救了打太极拳可明显改善

太极拳中诺医疗

太极拳能治糖尿病？

糖尿病——严重危害人类健康，是现代疾病中的一大杀手，对人体的危害仅次于肿瘤和心脑血管病。据估计，Ⅱ型糖尿病病人在全世界有两亿五千万人。在我国，它已超越高血压人群、成为第一大高发疾病。其中2型糖尿病约占糖尿病总数的90％～95％。

星期五, 06 9月 2019

香蕉是“通便高手”？错！小心越吃越便秘！

转载中诺医疗转自：广州市第一人民医院服务号

春节期间，走亲访友、同学聚会……少不了各种大鱼大肉的饭局，而数餐多荤少素的饮食令不少朋友的肠子已“不堪重负”，加上过年食用煎炸应节食品、坚果等，肠子急需“释放”。

这时，

不少人便想着吃几根香蕉来润肠通便。

然而现实是，有人一口气连吃好几根，

结果却便秘了。

怎么回事，

难道他吃的是假香蕉？

星期五, 06 9月 2019

重度渗出糖尿病足溃疡的管理

慢伤前沿中诺医疗

为了有效管理糖足溃疡（DFU）的伤口渗出，临床医生须理解渗出的本质和为何其从急性伤口愈合的必要成分变成了慢性伤口中的有害物质。渗液的管理需要了解患者的整体、考虑引起渗出增加的合并症、给予的治疗、皮肤质量和完整性、以及病人的生活质量。

星期五, 06 9月 2019

渗出物管理是伤口愈合过程管控中非常重要的一个环节，它可能贯穿整个伤口治疗的过程。国际伤口愈合联合会（WUWHS， World Union of Wound Healing Societies）在2007年曾经发布过一份关于渗出物管理的共识文件，时隔十二年，因为各种新的临床护理技术及方法的出现，WUWHS认识到临床需要更多、更新的指导意见，因此组织专家组对旧版本的共识文件进行了更新，并于2019年年初发布了新版文件。华阳医疗临床小组对此份文件进行了编译，因篇幅较长，所以内容将分几期进行转发推送，供各位老师参考，并对其中不足之处做出指正，感谢。

星期五, 06 9月 2019

不良情绪对疤痕的影响

中诺医疗

疤痕确实给广大疤友带来了无穷的痛苦，但是看到许多疤痕并不重的，甚至都算不上疤痕的人，大喊压力如何大，如何影响疤痕修复，去疤痕的方法不管用什么的。请你不要大喊，这不叫压力。相比人家脸部的疤痕，相比大面积的疤痕这根本不算什么，相对而言，别人那些大面积疤痕修复更加困难。

K2 Content

An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair 2024-11-25 00:00

Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5

1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea

2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea

4 UltraV Co., Ltd. R&D Center, Seoul, South Korea

5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea

Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

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Abstract

Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.

Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.

Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.

Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.

KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200
异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

10个成年人中就有一个得肾病，生活中常被忽视的6个伤肾小细节，特别是第6个！

北大医院：糖尿病有救了打太极拳可明显改善

香蕉是“通便高手”？错！小心越吃越便秘！

重度渗出糖尿病足溃疡的管理

【分享】国际共识文件--对伤口渗出物的有效评价及处理

不良情绪对疤痕的影响

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

10个成年人中就有一个得肾病，生活中常被忽视的6个伤肾小细节，特别是第6个！

北大医院：糖尿病有救了 打太极拳可明显改善

香蕉是“通便高手”？错！小心越吃越便秘！

重度渗出糖尿病足溃疡的管理

【分享】国际共识文件--对伤口渗出物的有效评价及处理

不良情绪对疤痕的影响

消息订阅

学术会议

伤口世界提示

北大医院：糖尿病有救了打太极拳可明显改善