干细胞ECM修复软骨缺损与鹿茸干细胞ECM的研究进展

王玉俗1，褚文辉2，李久波3，赵全民1N，李春义4※

(1．吉林农业大学中药材学院，吉林长春130118；2．台州学院生命科学学院，浙江台州317000；3．长春市农业机械研究院， 吉林长春130000；4．中国农业科学院特产研究所特种经济动物分子生物学国家重点实验室，吉林长春130112)

收稿日期：2019—10—19

基金项目：中国科学院A类战略性先导专项(XDAl6030305)

作者简介：王玉俗(1994一)，男，贵州省遵义市人，在读硕士研究生，从事特种经济动物干细胞及相关研究。

※通讯作者：李春义，男，教授，博士生导师，从事鹿茸生物学研究：赵全民，男，副教授，硕士生导师，从事经济动物疫病研究。

摘要：鹿茸软骨中富含血管，不但能修复缺陷还能实现再生，是研究软骨缺损修复的良好天然模型。由于鹿茸干细胞所分化的软骨分布着丰富的血管网络，所以其ECM中可能含有大量促进软骨生成的细胞因子和功能蛋白。本文就软骨缺陷修复进行综述，对使用鹿茸干细胞ECM修复软骨缺陷的初步结果进行总结，并提出展望。

关键词：软骨修复；ECM；干细胞；鹿茸  中图分类号：Q786   文献标识码：A   文章编号：1001-4721(2020)01．0064．05

Research Progress of Stem Cell Extracellular Matrix in Repairing Carti--lage Defects and Antler Stem Cell Extracellular Matrix

WANG Yu·SUl，CHU Wen-hui2，LI Jiu·b03，ZHAO Quan-minl※，LI Chun-yi4※

(1．College of Traditional Chinese Medicine，Jilin Agricultural University，Changchun 130118，China；2．Academy of Life Sciences，Taizhou University，Taizhou 317000China；3．Changchun Agricultural Machinery Research Institute，Changchun 130000，China；4．StateKey Laboratory for Molecular Biology of Special Economic Animals，Institute of Special Wild Economic Animals and Plants，Chinese Academy of Agricultural Sciences，Changchun 130112，China)

Abstract：Antler cartilage is rich in blood vessels，which can not only promote defect repair, but also regenerate itself, thus antler is a good animal model to use for the study of cartilage defect repair．Because the cartilage differentiated from antler stem cells is rich in vascular net—works，its extracellular matrix(ECM)contains a 1arge number of cytokines and functional proteins that can promote cartilage for mation．In this paper, the currentstatus of repairing cartilage defects was reviewed，and the preliminary results of using antler stem cell ECM to repair cartilage defects were summarized，and the prospects were put forward．

Key words：cartilage repair．ECM：stem cell：antler

Use of artificial intelligence in wound care education

Author: Corey Heerschap

Corey Heerschap is Wound/ Ostomy Clinical Nurse Specialist at Royal Victoria Regional Health Centre in Barrie, ON, Canada, and a PhD student at Queens University in Kingston, ON, Canada. He is the President-Elect of Nurses Specialized in Wound, Ostomy and Continence Canada, Inaugural Panel Member of the Canadian Pressure Injury Advisory Panel, and Education CoLead for the Commonwealth Wound Care Resource Alliance.

      Artificial intelligence is rapidly changing the healthcare landscape. Advancing technologies such as large language models are providing new tools for educating clinicians, students, and individuals living with wounds. Wound care clinicians should be aware of the benefits of this new technology, how it is impacting, and could impact, wound care education, and current limitations to the technology and tools available. This article outlines broadly the current state of AI in healthcare and discusses the implications of this technology on wound care education as well as its current limitations.

Corey Heerschap is Wound/Ostomy Clinical Nurse Specialist at Royal Victoria Regional Health Centre in Barrie, ON, Canada, and a PhD student at Queens University in Kingston, ON, Canada. He is the President-Elect of Nurses Specialized in Wound, Ostomy and Continence  Canada, Inaugural Panel Member of the Canadian Pressure Injury Advisory Panel, and Education CoLead for the Commonwealth Wound Care Resource Alliance.

Ten top tips: pressure ulcers on the heels

Author: Joyce Black

Joyce Black is Professor, College of Nursing, University of Nebraska Medical Center, Omaha, Nebraska, US

Despite the frequency of pressure ulcers on the heels, little is written about them. While these ten top tips will not fill the literature gap, it may help you with this common problem.

Pharmacological treatment of painful neuropathy in adults with diabetes

Helen O’Neil

Citation: O’Neil (2023) Pharmacological treatment of painful neuropathy in adults with diabetes. The Diabetic Foot Journal 26(1): 20–3

Key words

- Diabetic neuroarthropathy

- Neuropathic pain

- Pharmacological therapy

Article points

1. Painful diabetic neuropathy is common in people with diabetes and is difficult to manage clinically.

2. Guidelines recommend amitriptyline, duloxetine, gabapentin or pregabalin as initial pain management options.

3. Patients often do not respond to monotherapy, so combination pharmacotherapy may be required.

Author

Helen O’Neil is Senior Medicines Optimisation Pharmacist, South Tyneside and Sunderland NHS Foundation Trust, UK

Diabetic neuropathy is one of the most prevalent chronic complications in people living with diabetes and painful diabetic neuropathy is difficult to manage clinically. Guidelines recommend offering a choice of amitriptyline, duloxetine, gabapentin or pregabalin as initial treatment for neuropathic pain. It is recommended that pharmacotherapy is offered in a stepwise approach to ensure tolerability and effectiveness of individual medications. Patients often do not respond to monotherapy and, therefore, combination pharmacotherapy may be required. The aim of treatment is to improve quality of life for patients living with painful diabetic neuropathy by reducing pain and promoting increased participation in all aspects of daily living.

干细胞技术在抗衰老中的应用

王勤周1 王 辉1 综述，陈红艳2 审校

(1.陕西省医疗器械质量监督检验院 陕西 西安 712046；2.空军军医大学唐都医院惠宾科 陕西 西安 710038)

[摘要]随着人们生活质量的不断提高，抗衰老的要求日益增强。干细胞具有自我更新、多向分化和旁分泌因子分泌能力，在创伤修复、组织再生和抗衰老等临床医学领域显现出良好的应用前景。本文就干细胞在抗衰老、促进皮肤再生领域的研究进展进行综述，从自体干细胞的移植、内源性干细胞的刺激和外源性成体干细胞移植的作用及其机制等角度探讨了干细胞抗衰老的可行性。以期为未来相关医疗保健及美容产品的开发提供借鉴。

[关键词]衰老；抗衰老技术；干细胞；细胞移植；医学美容

[中图分类号]R622 [文献标志码]A [文章编号]1008-6455（2018）11-0170-04

通信作者：陈红艳，空军军医大学唐都医院惠宾科护士长，主管护师，高级美容技师；在文绣美容，问题性皮肤护理，痣、疣、斑的超高频治疗方面有丰富的临床工作及教学经验

第一作者：王勤周，陕西省医疗器械质量监督检验院，硕士研究生，副主任技师；研究方向：生物医学组织工程技术的应用；E-mail: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

The Application of Stem Cell Technology in the Field of Anti-aging

WANG Qin-zhou1 ,WANG Hui1 ,CHEN Hong-yan2

(1.Shaanxi Institute of Medical Device Quality Supervision and Inspection,Xi’an 712046,Shaanxi,China;2.Huibinke,Tangdu Hospital,Air Force Military Medical University,Xi’an 710038,Shaanxi,China)

Abstract: With the continuous improvement of people's life quality, the demand of anti-aging is increasing. Stem cells are non-specialized cells which have the ability of self-renewal, multiple differentiation and paracrine secretion. It has been shown that stem cells have good application prospects in the field of trauma repair, tissue regeneration and anti-aging. This paper reviewed the progress of stem cell research in the field of anti-aging and promoting skin regeneration. The feasibility of rejuvenation technologies by stem cells was discussed from the point of view of autologous stem cell transplantation, activation of endogenous stem cells, and the effect and its mechanism of exogenous stem cell transplantation. It will provide reference for future development of related medical care and beauty products.

Key words: senility; rejuvenation technologies; stem cells; cell transplantation; medical cosmetology

表皮细胞去分化的表皮干细胞

赵学凯，梁自乾，张宪发，宗守凯

Mature epidermal cells dedifferentiate towards epidermal stem cells

Zhao Xue-kai, Liang Zi-qian, Zhang Xian-fa, Zong Shou-kai

Department of Burn and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China

Zhao Xue-kai★,Studying for master’s degree, Department of Burn and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China zhaoxuekai3581@ 163.com

Correspondence to: Liang Zi-qian, Professor, Master’s supervisor, Department of Burn and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region,China Liangzqian@ yahoo.com.cn

Received: 2011-06-16 Accepted: 2011-10-10

广西医科大学第一附属医院烧伤整形外科，广西壮族自治区南宁市530021

赵学凯★，男，1985 年生，山东省滨州市人，汉族，广西医科大学在读硕士，主要从事创面愈合、表皮干细胞的研究。该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

通讯作者：梁自乾，教授，硕士生导师，广西医科大学第一附属医院烧伤整形外科，广西壮族自治区南宁市 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

中图分类号:R318

文献标识码:B

文章编号: 1673-8225 (2011)49-09295-04

收稿日期：2011-06-16

修回日期：2011-10-10 (20110516001/WL·W)

Abstract

BACKGROUND: Epidermal stem cells as seed cells have been paid great attention on the research of wound repair and regeneration with its specific biological advantages with the development of molecular biology and bioengineering.

OBJECTIVE: To review the recent advances in the mature epidermal cells dedifferentiating towards epidermal stem cells.

METHODS: The first author retrieved PubMed database, Highwire database (Highwire.standford.edu) and CNKI for articles published from January 1998 to January 2011. The key words were “dedifferentiation, epidermal stem cell, epidermal cell, induction” in English and Chinese. A total of 2 754 literatures were collected, and finally 46 papers were included in result analysis.

RESULTS AND CONCLUSION: The dedifferentiated epidermal stem cells have some characteristics of native epidermal stem cells and perhaps they may act as a new vehicle for wound repair and regeneration. Both of the native epithelial stem cells and the dedifferentiated epithelial stem cells can promote the wound repair and their effects were on the same level. Because differentiation from epidermal cells into epidermal stem cells has many questions, so far, there are many animal researches, but its extensive clinical application deserves further development.

Zhao XK, Liang ZQ, Zhang XF, Zong SK. Mature epidermal cells dedifferentiate towards epidermal stem cells.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(49):9295-9298. [http://www.crter.cn http://en.zglckf.com]

摘要

背景：表皮干细胞以显著的自我更新和多向分化潜能及皮肤组织工程学中诱人的应用前景，作为“种子细胞”成为皮肤创伤研究领域的热点之一。

目的：综述表皮细胞去分化逆转为表皮干细胞的研究近况。

方法：应用计算机检索 1998-01/2011-01 PubMed、Highwire 和中国期刊全文数据库相关文章，检索词“dedifferentiation，epidermal cells，epidermal stem cells，induction，去分化，表皮细胞，表皮干细胞，诱导”。共检索到文献 2 754 篇，最终纳入符合标准的文献 46 篇。

结果与结论：去分化来源的表皮干细胞与机体自身来源的表皮干细胞之间在形态学和功能有许多相似点，并可表达表皮干细胞的特异性标记物。表皮细胞去分化途径制造表皮干细胞，可以作为机体自身来源表皮干细胞的替代细胞应用于皮肤损伤重建和再生的相关研究，为实现皮肤创伤由解剖修复到功能修复的“完美修复”提供新思路。

关键词：表皮细胞；去分化；表皮干细胞；诱导；皮肤组织工程；创面愈合；综述文献

doi:10.3969/j.issn.1673-8225.2011.49.041

赵学凯，梁自乾，张宪发，宗守凯．表皮细胞去分化的表皮干细胞[J].中国组织工程研究与临床康复，2011，15(49):9295-9298.

[http://www.crter.org http://cn.zglckf.com]