伤口世界

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星期一, 09 12月 2019

糖尿病患者易于合并的“老年综合征”

原创： tjx 糖尿病天地

疾病之间并不是独立存在的，尤其是糖尿病，如果糖尿病患者不积极控制血糖，可能会导致多种并发症，而各种并发症之间也会有密切的关系，如糖尿病肾病和糖尿病视网膜病变都是糖尿病的微血管并发症，许多糖尿病肾病患者会同时合并有糖尿病眼底病变；如糖尿病肾病患者一般都会出现高血压。

星期一, 09 12月 2019

糖尿病患者如何做好日常足部护理

原创：国际糖尿病

糖尿病患者通常面临哪些足部问题，应该采取哪些日常护理措施？以下让我们来聆听美国田纳西州退伍军人医疗中心足部医疗部门主任Mark Hinkes医生的观点，Hinkes医生还是Healthy Feet for People With Diabetes一书的作者。

星期一, 09 12月 2019

糖尿病蜜月期：我们需要知道什么？

原创：国际糖尿病

　　部分患者初诊为1型糖尿病并开始胰岛素治疗时，其血糖水平正常或接近正常，糖尿病症状消失。即使应用小剂量胰岛素，其血糖水平也近乎正常，有些患者甚至可以暂时停用胰岛素。这种情况被称为“糖尿病蜜月期”。

星期一, 09 12月 2019

治疗1型糖尿病，或能从肠道微生物入手

原创：国际糖尿病

　　澳大利亚昆士兰大学Emma Hamilton Williams等人发现，关注肠道的微生物（微生物群）可能有助于预防1型糖尿病，研究结果近日发表于Microbiome杂志。

星期一, 09 12月 2019

德谷门冬双胰岛素中国上市，全球首个双胰岛素为中国糖尿病患者而来

原创：国际糖尿病

导语：德谷门冬双胰岛素开启糖尿病治疗新时代！

星期一, 09 12月 2019

糖尿病教育必须包括口腔健康教育

原创：国际糖尿病

　　如何了解糖尿病患者的口腔问题，如何使糖尿病患者保持口腔健康？下面是美国南佛罗里达大学Jerry Brown医生的观点，他是美国第一个成为糖尿病教育者（CDE）的牙医。

K2 Content

Efficacy of probiotics in hair growth and dandruff control: A systematic review and meta-analysis 2024-11-28 00:00

Chang-Shik Yin a,1 , Trang Thi Minh Nguyen b,1 , Eun-Ji Yi b,c , Shengdao Zheng b,c , Arce Defeo Bellere b , Qiwen Zheng b , Xiangji Jin d , Myeongju Kim b , Sejic Park b , Sarang Oh b,c , Tae-Hoo Yi b,

a Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

b Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin, Republic of Korea

c Snowwhitefactory Co, Ltd., 807 Nonhyeon-ro, Gangnam-gu, Seoul, 06032, Republic of Korea

d Department of Pharmacology, School of Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dong-daemun, Seoul, Republic of Korea

ABSTRACT

Background: Probiotics are intellectually rewarding for the discovery of their potential as a source of functional food. Investigating the economic and beauty sector dynamics, this study conducted a comprehensive review of scholarly articles to evaluate the capacity of probiotics to promote hair growth and manage dandruff.

Methods: We used the PRISMA 2020 with Embase, Pubmed, ClinicalTrials.gov, Scopus, and ICTRP databases to investigate studies till May 2023. Meta-analyses utilizing the random effects model were used with odds ratios (OR) and standardized mean differences (SMD).

Result: Meta-analysis comprised eight randomized clinical trials and preclinical studies. Hair growth analysis found a non-significant improvement in hair count (SMD = 0.32, 95 % CI -0.10 to 0.75) and a significant effect on thickness (SMD = 0.92, 95 % CI 0.47 to 1.36). In preclinical studies, probiotics significantly induced hair follicle count (SMD = 3.24, 95 % CI 0.65 to 5.82) and skin thickness (SMD = 2.32, 95 % CI 0.47 to 4.17). VEGF levels increased significantly (SMD = 2.97, 95 % CI 0.80 to 5.13), while IGF-1 showed a non-significant inducement (SMD = 0.53, 95% CI -4.40 to 5.45). For dandruff control, two studies demonstrated non-significant improvement in adherent dandruff (OR = 1.31, 95 % CI 0.13–13.65) and a significant increase in free dandruff (OR = 5.39, 95 % CI 1.50–19.43). Hair follicle count, VEGF, IGF-1, and adherent dandruff parameters were recorded with high heterogeneity. For the systematic review, probiotics have shown potential in improving hair growth and controlling dandruff through modulation of the immune pathway and gut-hair axis. The Wnt/β-catenin pathway, IGF-1 pathway, and VEGF are key molecular pathways in regulating hair follicle growth and maintenance.

Conclusions: This review found significant aspects exemplified by the properties of probiotics related to promoting hair growth and anti-dandruff effect, which serve as a roadmap for further in-depth studies to make it into pilot scales.

ARTICLE INFO

Keywords: Probiotic Hair loss Alopecia Hair growth Dandruff Scalp

* Corresponding author.

E-mail address: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (T.-H. Yi).

1 These authors contributed equally to this work.
Efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms 2024-11-27 00:00

Xianghua Zhang1 Delphine Kerob2 Zhongxing Zhang1 Han Tao1 Xiaofeng He3 Yi Yi3 Xiaofeng Fang3 Wenna Wang3 Andrew Steel3

1 L’Oreal Dermatological Beauty, L’Oréal China, Shanghai, China

2 La Roche-Posay Laboratoire Pharmaceutique, Levallois Perret, La Roche-Posay, France

3 Research and Innovation Center, L’Oréal China, Shanghai, China

Correspondence

Xianghua Zhang, L’Oreal Dermatological Beauty, L’Oréal China, Shanghai, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: Sensitive skin is a common condition affecting a significant proportion of the population, and there is a growing demand for effective and safe management.

Aim: To evaluate the efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate as an optimal care for facial sensitive skin.

Methods: A total of 110 participants (64 in group A and 46 in group B) with facial sensitive skin applied the cream twice daily for 28 days. Group A evaluated their sensitive skin, product efficacy, and product use experience at D0 (15 min), D1, D14, and D28. In group B, skin barrier function-related indicators were measured at baseline and on D1, D7, D14, and D28. Dermatologists evaluated tolerance for all participants.

Results: After 28 days of use, in group A, 100% of participants reported mildness and comfort with product use. Participants demonstrated significant improvements in skin barrier function-related indicators, including increased stratum corneum moisture content, reduced erythema index, elevated sebum content, decreased trans-epidermal water loss, and diminished skin redness parameter a* value (all p < 0.05). Dermatologist evaluations revealed excellent tolerance among all participants.

Conclusion: The panthenol-enriched cream with prebiotics and probiotic lysate exhibited substantial clinical efficacy in ameliorating facial sensitive skin conditions, coupled with a high safety profile.

KEYWORDS panthenol, prebiotics, probiotics, sensitive skin, skin barrier function
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study 2024-11-26 00:00

Marta Arnal‑Forné1 · Tamara Molina‑García2 · María Ortega2 · Víctor Marcos‑Garcés2,3 · Pilar Molina4 · Antonio Ferrández‑Izquierdo1,2,5 · Pilar Sepulveda1,6,7 · Vicente Bodí2,3,6,8 · César Ríos‑Navarro1,2,6 · Amparo Ruiz‑Saurí1,2,6

Accepted: 10 June 2024 / Published online: 2 July 2024

© The Author(s) 2024

Abstract

Skin represents the main barrier against the external environment, but also plays a role in human relations, as one of the prime determinants of beauty, resulting in a high consumer demand for skincare-related pharmaceutical products. Given the importance of skin aging in both medical and social spheres, the present research aims to characterize microscopic changes in human skin composition due to intrinsic aging (as opposed to aging infuenced by external factors) via histological analysis of a photoprotected body region. Samples from 25 autopsies were taken from the periumbilical area and classifed into four age groups: group 1 (0–12 years), group 2 (13–25 years), group 3 (26–54 years), and group 4 (≥55 years). Diferent traditional histological (hematoxylin–eosin, Masson’s trichrome, orcein, toluidine, Alcian blue, and Feulgen reaction) and immunohistochemical (CK20, CD1a, Ki67, and CD31) stains were performed. A total of 1879 images photographed with a Leica DM3000 optical microscope were morphometrically analyzed using Image ProPlus 7.0 for further statistical analysis with GraphPad 9.0. Our results showed a reduction in epidermis thickness, interdigitation and mitotic indexes, while melanocyte count was raised. Papillary but not reticular dermis showed increased thickness with aging. Specifcally, in the papillary layer mast cells and glycosaminoglycans were expanded, whereas the reticular dermis displayed a diminution in glycosaminoglycans and elastic fbers. Moreover, total cellularity and vascularization of both dermises were diminished with aging. This morphometric analysis of photoprotected areas reveals that intrinsic aging signifcantly infuences human skin composition. This study paves the way for further research into the molecular basis underpinning these alterations, and into potential antiaging strategies.

Keywords Skin aging · Intrinsic aging · Morphometric analysis · Human biopsies

César Ríos-Navarro

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Amparo Ruiz-Saurí 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

1 Department of Pathology, University of Valencia, Avda. Blasco Ibáñez 15. 46010, Valencia, Spain

2 Instituto de Investigación Sanitaria INCLIVA Biomedical Research Institute, Avda. Menéndez Pelayo 4acc,

46010 Valencia, Spain

3 Cardiology Department, Hospital Clínico Universitario, Valencia, Spain

4 Department of Pathology, Instituto de Medicina Legal y Ciencias Forenses, Valencia, Spain

5 Anatomic Pathology Department, Hospital Clínico Universitario, Valencia, Spain

6 Centro de Investigación Biomédica en Red (CIBER)-CV, Madrid, Spain

7 Regenerative Medicine and Heart Transplantation Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain

8 Department of Medicine, University of Valencia, Valencia, Spain

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病患者易于合并的“老年综合征”

糖尿病患者如何做好日常足部护理

糖尿病蜜月期：我们需要知道什么？

治疗1型糖尿病，或能从肠道微生物入手

德谷门冬双胰岛素中国上市，全球首个双胰岛素为中国糖尿病患者而来

糖尿病教育必须包括口腔健康教育

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病患者易于合并的“老年综合征”

糖尿病患者如何做好日常足部护理

糖尿病蜜月期：我们需要知道什么？

治疗1型糖尿病，或能从肠道微生物入手

德谷门冬双胰岛素中国上市，全球首个双胰岛素为中国糖尿病患者而来

糖尿病教育必须包括口腔健康教育

消息订阅

学术会议

伤口世界提示