黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1
1 中山大学附属第一医院烧伤科,广州 510080;
2 南通大学附属医院烧伤整形外科 226001;3 深圳大学第一附属医院烧伤整形科 518037 通信作者:朱家源,Email:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Shaobin Huang1,2† , Zhicheng Hu1† , Peng Wang1 , Yi Zhang3 , Xiaoling Cao1 , Yunxian Dong1 , Pu Cheng1 , Hailin Xu1 ,
Wenkai Zhu4 , Bing Tang1* and Jiayuan Zhu1*
Abstract
Background: Full-thickness wounds severely affect patients’ life quality and become challenging problems for clinicians. Stem cells have great prospects in the treatment of wounds. Our previous study confirmed that autologous basal cell suspension could promote wound healing, and epidermal stem cells (ESCs) were detected in the basal cell suspension. Herein, this study aimed to explore the effect of ESCs on full-thickness wounds.
Methods: Rat ESCs were isolated and expanded and then were transfected with lentivirus to stably express enhanced green fluorescent protein. The experimental rats were randomly divided into 2 groups: in the ESC group, the rat ESCs were sprayed on the full-thickness wounds of rats; in the control group, phosphate-buffered saline was sprayed the on the wounds. Next, wound healing and neovascularization were evaluated. Colonization, division, and differentiation of ESCs on the wound were analyzed by immunofluorescence.
Results: The rat ESCs colonized, divided, and proliferated in the wound. Additionally, rat ESCs around blood vessels differentiated into vascular endothelial cells and formed a lumen-like structure. Compared with the control group, the ESC group showed enhanced angiogenesis and accelerated wound healing.
Conclusions: Our study confirmed that rat ESCs are safe and effective for treating full-thickness wounds. Additionally, under certain conditions, ESCs can differentiate into vascular endothelial cells to promote angiogenesis and wound healing.
Keywords: ESCs, Cell differentiation, Angiogenesis, Full-thickness wounds
原创:伤口治疗及造口护理中心
不管哪种肤质,哪怕是“天生丽质”的人,都会存在或多或少的小毛病,每种不同的肤质可能出现的问题也各有侧重,当皮肤出现问题时就应该警醒了,应该立即审视和调整你的计划,那么我们应该如何科学评估自己的皮肤?今天小编就告诉大家医生及伤口师是如何评估我们的皮肤的。
皮肤是作为人类健康与美丽的象征,当我们最初注意到一个人时,她健康的肌肤往往是形成美好的第一印象的重要因素。
健康与美丽是分不开的,尤其是对皮肤来说,这一点更加重要,如果没有了健康,便根本谈不上皮肤的美丽。
在日常的工作、学习、生活中,难免会有磕磕碰碰,时不时我们的身体就是因某些原因,造成不可避免的伤口出现。有时我们会发现,有些伤口会快速愈合甚至不留痕迹,而有些伤口经久不愈甚至情况愈演愈烈,造成不可挽回的后果,只有我们能够简单的初步认识伤口的各种情况,才能更好地对待我们所发生的一些伤口情况,使其快速愈合,让我们的身体恢复健康。
今天,小编就给大家讲解一下什么是伤口以及伤口的分类。
在日常生活中,当我们的机体受到伤害而造成伤口的时候,最希望伤口能够尽快愈合,恢复到未受伤时候的状态。通过观察不难发现,伤口几乎是一天一个样,那么机体是如何让伤口产生这些变化的呢?伤口有时如何进行修复的呢?
今天小编就告诉大家伤口的愈合过程,通过了解这个过程,我们能够更好地了解自己伤口所处在的周期,以及能够大概了解伤口是往好的方向发展还是往坏的方向恶化。话不多说,下面介绍今天的主题!
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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