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世界艾滋病日：主动检测，知艾防艾，共享健康！

胡大夫负压引流与创面修复

世界艾滋病概况：

自1981年世界第一例艾滋病病毒感染者发现至今，短短30多年间，艾滋病在全球肆虐流行，已成为重大的公共卫生问题和社会问题，引起世界卫生组织及各国政府的高度重视；

自艾滋病病毒开始流行以来，在全世界已经有超过6000万人感染了艾滋病毒，其中2200万人已经死亡。

案例分享：铁钉扎伤糖足的处理！

原创：胡海涛负压引流与创面修复

从洗脚开始，治疗足溃疡、糖尿病足！

胡海涛负压引流与创面修复

慢性伤口，表面已经证实存在细菌或生物膜，只依靠消毒剂杀灭细菌，这是很难达到清创效果的。

《今日说法》创办人之一肖晓琳因直肠癌离世的遗言？

萤火虫医生负压引流与创面修复

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K2 Content

Tailoring biomaterials for skin anti-aging 2025-05-23 00:00

Xin Dan a,1 , Songjie Li a,1 , Han Chen a , Ping Xue a , Bo Liu a , Yikun Ju b , Lanjie Lei c,**,

Yang Li a,***, Xing Fan a,*

a Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China

b Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China

c Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, China

* Corresponding author.

** Corresponding author.

*** Corresponding author.

E-mail addresses: leilanjie1988@163.com (L. Lei), liyangzx@fmmu.edu.cn (Y. Li), fanxing.612@163.com (X. Fan).

1 These authors contributed equally to this work and shared the first authorship.

ARTICLE INFO

Keywords:

Biomaterials、Skin anti-aging、Plastic surgery、Tissue regeneration、Medical aesthetics

ABSTRACT

Skin aging is the phenomenon of degenerative changes in the structure and function of skin tissues over time and is manifested by a gradual loss of skin elasticity and firmness, an increased number of wrinkles, and hyperpigmentation. Skin anti-aging refers to a reduction in the skin aging phenomenon through medical cosmetic technologies. In recent years, new biomaterials have been continuously developed for improving the appearance of the skin through mechanical tissue filling, regulating collagen synthesis and degradation, inhibiting pigmentation, and repairing the skin barrier. This review summarizes the mechanisms associated with skin aging, describes the biomaterials that are commonly used in medical aesthetics and their possible modes of action, and discusses the application strategies of biomaterials in this area. Moreover, the synergistic effects of such biomaterials and other active ingredients, such as stem cells, exosomes, growth factors, and antioxidants, on tissue regeneration and anti-aging are evaluated. Finally, the possible challenges and development prospects of biomaterials in the field of anti-aging are discussed, and novel ideas for future innovations in this area are summarized.
Curcumin and EGCG combined formulation in nanostructured lipid carriers for anti-aging applications 2025-05-19 00:00

Chidchanok Prathumwon a , Songyot Anuchapreeda b , Kanokwan Kiattisin a , Pawaret Panyajai b , Panikchar Wichayapreechar d , Young-Joon Surh e , Chadarat Ampasavate a,c,*

a Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand

b Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand

c Center for Excellence in Pharmaceutical Nanotechnology, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand

d Department of Cosmetic Sciences, School of Pharmaceutical Sciences, University of Phayao, Phayao 56000, Thailand

e College of Pharmacy, Seoul National University, Seoul 151-741, South Korea

Corresponding author at: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

E-mail address: chadarat.a@cmu.ac.th (C. Ampasavate).

ABSTRACT

Curcumin (Cur) and epigallocatechin gallate (EGCG), the primary active compounds in turmeric and green tea, respectively, have been investigated for their anti-aging potential. The Cur and EGCG combination was encapsulated in sustained-release nanostructured lipid carriers (NLCs) to enhance their bioactivities and pharmaceutical properties. A significant enhancement in the antioxidant activities of the Cur and EGCG combination was observed at an optimal ratio, as demonstrated by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay (118.83 ± 3.78 %), ferric ion reducing antioxidant power assay (217.25 ± 13.45 %), and lipid peroxidation inhibition assay (106.08 ± 12.93 %), compared to Cur alone without compromising the antioxidant activities and total phenolic content of EGCG. This is due to the enhancement of total phenolic content of the combination of 218.83 ± 10.57 %. For anti-aging activities, the combination exhibited stimulation of SIRT1 protein and inhibition of collagenase and elastase of 27.53 ± 0.73 %, 43.70 ± 1.05 % and 51.76 ± 6.52 % compared with that achieved with Cur alone, respectively. The incorporation of the Cur and EGCG combination into NLCs resulted in high entrapment efficiencies of 98.60 ± 0.05 % for Cur and 98.40 ± 0.08 % for EGCG, with corresponding loading capacities of 0.789 ± 0.001 % and 3.935 ± 0.003 %, respectively. When formulated NLCs into an emulgel base, the system demonstrated sustained release profiles over 48 h, with 12.82 ± 0.99 % release of Cur and 63.77 ± 5.76 % release of EGCG. Significant skin retention was also observed after 24 h, with 23.88 ± 1.71 % Cur and 22.79 ± 4.65 % EGCG retained in the skin. Therefore, Cur: EGCG-loaded NLCs in emulgel can deliver the active compounds into the dermis, enhancing skin penetration, sustained delivery, and anti-aging activity superior to each conventional single active compound in topical formulations.

ARTICLE INFO

Keywords: Curcumin Epigallocatechin gallate SIRT1 Anti-aging HaCaT cells Nanostructured lipid carriers Skin
Small molecule conjugates with selective estrogen receptor b agonism promote anti-aging benefits in metabolism and skin recovery 2025-05-16 00:00

Tarik Zahra,b,y , Vijay K. Bodac,d,y , Jian Gee,f,y , Lexiang Yua,g , Zhongzhi Wuc,d , Jianwen Quee,f,h, *, Wei Lic,d, *, Li Qianga,g, *

a Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA

b Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY 10032, USA

c Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA

d Drug Discovery Center, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA

e Division of Digestive and Liver Diseases, Columbia University, New York, NY 10032, USA

f Center for Human Development, Columbia University, New York, NY 10027, USA

g Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA

h Department of Medicine, Columbia University, New York, NY 10032, USA

*Corresponding authors.

E-mail addresses: jq2240@cumc.columbia.edu (Jianwen Que), wli@uthsc.edu (Wei Li), lq2123@cumc.columbia.edu (Li Qiang).

These authors made equal contributions to this work.

Peer review under the responsibility of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Received 22 October 2023; received in revised form 13 December 2023; accepted 5 January 2024

KEY WORDS Estrogen receptor b; Aging; Metabolism; Skin injury; Muscle metabolism; Small molecule conjugates; Regeneration; Adiposity

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

世界艾滋病日：主动检测，知艾防艾，共享健康！

案例分享：铁钉扎伤糖足的处理！

从洗脚开始，治疗足溃疡、糖尿病足！

《今日说法》创办人之一肖晓琳因直肠癌离世的遗言？

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

世界艾滋病日：主动检测，知艾防艾，共享健康！

案例分享：铁钉扎伤糖足的处理！

从洗脚开始，治疗足溃疡、糖尿病足！

《今日说法》创办人之一肖晓琳因直肠癌离世的遗言？

消息订阅

学术会议

伤口世界提示