Robert Chmielewski1–3 , Aleksandra Lesiak4,5
1 Prime Clinic, Warsaw, Poland;
2 Positive Pro-Aging Foundation, Warsaw, Poland;
3 URGO Aesthetics Department, URGO, Warsaw, Poland;
4 Dermoklinika Medical Center, Lodz, Poland; 5 Department of Dermatology, Pediatric Dermatology and Oncology, Laboratory of Autoinflammatory, Genetic and Rare Skin Disorders, Medical University of Lodz, Lodz, Poland Correspondence: Aleksandra Lesiak, Department of Dermatology, Pediatric Dermatology and Oncology, Laboratory of Autoinflammatory, Genetic and Rare Skin Disorders, Medical University of Lodz, 16 Pankiewicza Street, Lodz, Poland, 91-738, Email 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Abstract: This comprehensive review explores the pivotal roles of glycation and oxidative stress in the aging process of the skin, their targeted therapeutic applications in aesthetic and regenerative medicine, as well as anti-aging interventions. Glycation, a biochemical process involving the non-enzymatic attachment of sugars to proteins, lipids, or nucleic acids, culminates in the formation of Advanced Glycation End products (AGEs). These AGEs are significant contributors to aging and various chronic ailments, triggering oxidative stress and inflammatory pathways, thereby manifesting as wrinkles, diminished skin elasticity, and other age-related dermal alterations. A central focus of this review is the synergistic interplay between Hyaluronic Acid (HA) and Trehalose in combating these aging mechanisms. HA, renowned for its anti-inflammatory and antioxidative properties, assumes a pivotal role in modulating Reactive Oxygen Species (ROS) levels and safeguarding against oxidative damage. Concurrently, trehalose targetsglycation and oxidative stress, exhibiting promising outcomes in augmenting skin health, providing Ultraviolet B (UVB) photoprotection, and manifesting notable anti-photoaging effects. The combined administration of HA and trehalose not only addresses existing skin damage but also confers preventive and reparative benefits, particularly in stabilizing HA and mitigating glycation-induced stress. Their synergistic action significantly enhances skin quality and mitigates inflammation. The implications of these findings are profound for the future of anti-aging therapeutics in aesthetic medicine, suggesting that the integration of HA and trehalose holds promise for revolutionary advancements in preserving skin vitality and health. Moreover this paper underscores the imperative for continued research into the combined efficacy of these compounds, advocating for innovative therapeutic modalities in aesthetic medicine and enhanced strategies for combating aging, glycation, and oxidative stress.
Keywords: hyaluronic acid, trehalose, skin aging, glycation, oxidative stress, anti-aging therapies
Juewon Kim1,
*, Hyeryung Kim2 , Woo-Young Seo3 , Eunji Lee3 and Donghyun Cho4
1 Department of Physiology, Konkuk University College of Medicine, Chungju 27478,
2 GENINUS Inc., Seoul 05836,
3 ABIOTECH Co., Ltd., Suwon 16675,
4 HEM pharma, Suwon 16229, Republic of Korea
Abstract
Longevity genes and senescence-related signaling proteins are crucial targets in aging research, which aims to enhance the healthy period and quality of life. Identifying these target proteins remains challenging because of the need for precise categorization and validation methods. Our multifaceted approach combined bioinformatics with transcriptomic data to identify collagen as a key element associated with the lifespan of the model organism, Caenorhabditis elegans. By analyzing transcriptomic data from long-lived mutants that involved mechanisms such as antioxidation, dietary restriction, and genetic background, we identified collagen as a common longevity-associated gene. We validated these findings by confirming that collagen peptides positively affect lifespan, thereby strengthening the validity of the target. Further verification through healthspan factors in C. elegans and functional assays in skin fibroblasts provided additional evidence of the role of collagen in organismal aging. Specifically, our study revealed that collagen type VII is a significant target protein for mitigating age-related decline. By validating these findings across different aging models and cell-based studies, we present compelling evidence for the anti-aging effects of collagen type VII, highlighting its potential as a target for promoting healthy aging. This study proposes that collagen not only serves as an indicative marker of organismal longevity across various senescence-related signaling pathways, but also offers a mechanistic understanding of skin degeneration. Consequently, collagen is an effective target for interventions aimed at mitigating skin aging. This study underscores the potential of collagen type VII (bonding collagen T7) as a therapeutic target for enhancing skin health and overall longevity.
Key Words: Collagen VII, Healthspan, C. elegans, Skin aging, Bonding collagen
https://doi.org/10.4062/biomolther.2024.127
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Aug 1, 2024 Revised Sep 10, 2024 Accepted Sep 30, 2024
Published Online Oct 21, 2024
*
Corresponding Author
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原创: 十六点五 中山二院糖尿病足中心
脓腔切开,3型安尔碘纱布填塞一天之后,重新打开伤口,进行第二次清创,这次清创也是非常重要的。一般需要完成三个任务:探查创面、鉴别坏死及感染的组织、仔细清除各种需要清除的组织。
(3)要把足部被细菌侵袭的各个空隙最好都能打开,尤其是足部比较重要的“空隙”,也是为了引流充分。
糖尿病足的创面清创术是最有效的局部抗菌治疗。毛主席很早之前就教导我们:扫把不到灰尘照例不会自己跑掉,糖尿病足清创术就是治疗糖尿病足局部创面上的“灰尘”(细菌)最有效的“扫把”。
糖尿病足创面难愈合的原因很多,但细菌感染是其中最重要的原因。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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