文献精选

Role of Vitamin C in Skin Diseases

This article is excerpted from the 《Frontiers in Physiology》 by Wound World

Screening method and metabolic analysis of plant anti-aging microorganisms via ammoniainduced senescence in the duckweed Wolffia microscopica

This article is excerpted from the 《Journal of Fungi》 by Wound World

Identification of Flavoanoids From Finger Citron and Evaluation on Their Antioxidative and Antiaging Activities

This article is excerpted from the 《Frontiers in Nutrition》by Wound World

Exploring Greek actinobacterial biodiversity for the discovery of bioactive metabolites with skin antiaging potential

This article is excerpted from the 《Frontiers in Microbiology》 by Wound World

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Associations between cardiometabolic traits and diabetic cardiomyopathy: an imaging-based analysis 2026-04-29 00:00

Georgios Mavraganis1 · Dimitrios Bampatsias1,2 · Christina Konstantaki1 · Kamil Stankowski3,4 ·Stavros Athanasopoulos1 · Chrysoula Moustou1 · Alexandros Alexandropoulos1 · Stefano Figliozzi3,4 ·Angelos Soranides1 · Ioannis Petropoulos1 · Dimitrios Klettas5 · Kimon Stamatelopoulos1,6 ·Georgios Georgiopoulos1,7

Received: 12 December 2025 / Accepted: 15 March 2026 © The Author(s) 2026

Abstract

Introduction Diabetic cardiomyopathy (DCM) often evades diagnosis before manifestation of clinical symptoms. In this study we explored how cardiometabolic traits influence early cardiac structure and function in asymptomatic people living with diabetes (PwD), using advanced imaging.

Methods We conducted a cross-sectional study of 88 participants: 57 people living with type 2 diabetes (PwT2D), 16 people living with type 1 diabetes (PwT1D) and 15 controls. All subjects underwent transthoracic echocardiography and/or cardiac magnetic resonance (CMR) imaging. Strain analysis, perfusion indices, and tissue characterization (T1, T2, and extracellular volume) were assessed. Arterial stiffness via pulse wave velocity (PWV), ventricular-arterial coupling (VAC), circulating biomarkers and liver fibrosis indices were evaluated.

Results PwD had lower cardiac index than controls. Global longitudinal strain (GLS) and global radial strain were lower in both diabetes mellitus (DM) groups, while left atrial strain was most impaired in PwT2D (β-coefficient= − 11.77, P=0.003). DM duration≥10 years was associated with worse GLS (β-coefficient= − 2.18, P=0.033) and right VAC (β-coefficient= − 0.27, P=0.027) after multivariable analysis. While tissue characterization and perfusion indices showed no significant group differences, tight glycemic control in PwD correlated with improved myocardial strain parameters. PwT2D exhib-ited greater arterial stiffness (β-coefficient=1.52, P=0.003). In PwD, elevated non-alcoholic fatty liver disease score cor-related with increased left ventricular mass (β-coefficient=6,195, P=0.022) and decreased left ventricular ejection fraction (LVEF) (β-coefficient= − 3.12, P=0.017). Higher growth differentiation factor levels were associated with reduced LVEF (β-coefficient= − 0.005, P=0.029).

Conclusion This multimodal imaging study highlights myocardial and vascular changes in asymptomatic PwD. Early com-prehensive cardiovascular assessment may help identify dysfunction before overt heart failure develops.

Keywords Diabetic cardiomyopathy · Cardiac magnetic resonance · Echocardiography · Arterial stiffness · Ventricular-arterial coupling · Liver fibrosis
Role of automated insulin delivery (AID) systems in glucose control in patients with diabetes mellitus undergoing dialysis in Calabria: AID-DIAL-CAL 2026-04-28 00:00

Elena Succurro1,2 · Giuseppe Cersosimo3 · Paola Sarnelli4 · Francesco Brisinda1 · Ilaria Gattuso1 · Valeria Mazza1 ·Giuseppe Fabiano1 · Fiorella Iorio3 · Roberta Arena3 · Giovanni Mazzitello5 · Ramona Nicotera5 · Maria Capria1 ·Gianluigi Zaza6 · Michele Andreucci1 · Raffaele Mancini5 · Francesco Andreozzi1,2

Received: 22 December 2025 / Accepted: 16 March 2026© The Author(s) 2026

Abstract

Aims To describe the main glycemic outcomes and the Quality of Life (QOL) observed in a cohort of people with type 1(T1D) or type 2 (T2D) insulin-treated diabetes under dialysis who started an Automated Insulin Delivery (AID) system.

Methods This is a longitudinal retrospective pilot real-world analysis of 14 individuals with T1D and T2D undergoingdialysis who began using an AID system to optimize glycemic control. All subjects used the MiniMed™ 780G system. Glu-cose metrics were collected at baseline, 3, 6, and 12 months after initiating the SmartGuard™ feature. The WHOQoL-Bref questionnaire was administered at the last follow-up to evaluate the QOL.

Results Out of the 14 people, 8 reached 1-year follow-up. Time in Range (TIR) increased from 63% at baseline to 69% at 12 months, Time Below Range <70 mg/dL (TBR70) decreased from 0.3% to 0%, and Time Above Range >250 mg/dL (TAR250) decreased from 6.7% to 3.9%. Seven out of eight subjects who reached a 12-month follow-up achieved all three glycemic targets for this fragile population (TIR>50%, TBR70<1% and TAR250<10%). At the last follow-up, 58.3% of the users were satisfied or very satisfied with their health status, versus only 25% with the previous treatment, and 81.7% had a good or very good QOL, whereas only 8.3% had a good QOL, and no one had a very good QOL with the previous

Conclusion This pilot real-world study showed how the use of an AID system is safe and can help to improve the glycemic outcomes and the QOL of people with diabetes in dialysis.

Keywords Automated insulin delivery system · End-stage kidney disease · Dialysis · Time in range · Diabetes mellitus · Quality of Life

Communicated by Salvatore Corrao, M.D

Elena Succurro

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1 Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, Catanzaro 88100, Italy

2 Research Center for the Prevention and Treatment of Metabolic Diseases (CR METDIS), University Magna Graecia of Catanzaro, Catanzaro, Italy

3 Azienda Ospedaliera Annunziata Cosenza, Cosenza, Italy

4 ASL Viterbo, Viterbo, Italy

5 ASP Catanzaro, Catanzaro, Italy

6 Department of Civil Engineering, University of Calabria, Rende, Italy
“表皮屏障受损及分层修复”新理念 2026-04-27 00:00

何黎

［摘要］广义的皮肤屏障包括物理屏障、神经屏障、色素屏障及免疫屏障。狭义的皮肤屏障通常指表皮屏障。既往研究主要集中在角质层，忽视了表皮其他层次的屏障修复。近年研究表明，多种皮肤疾病及皮肤问题的表皮屏障受损不仅在角质层，还涉及颗粒层、棘层及基底层，且角化包膜、细胞间脂质及紧密连接蛋白变化也是表皮屏障受损的关键因素。但迄今为止，仍缺乏对表皮屏障不同层次受损机制及干预的系统探讨。本文提出“表皮屏障受损及分层修复”新理念，为表皮屏障受损不同层次的精准修复提供理论依据及临床应用新视角。

［关键词］皮肤屏障；表皮屏障；屏障修复；紧密连接蛋白

［中图分类号］Ｒ７５１［文献标志码］Ａ［文章编号］１００１－７０８９（２０２５）０９－０９４５－０８［ＤＯＩ］１０．１３７３５／ｊ．ｃｊｄｖ．１００１⁃７０８９．２０２５０２０２８

ＴｈｅＮｅｗＣｏｎｃｅｐｔｏｆ “ＥｐｉｄｅｒｍａｌＢａｒｒｉｅｒＤａｍａｇｅａｎｄＳｔｒａｔｉｆｉｅｄＲｅｐａｉｒ”ＨＥＬｉ１，２

（１．ＤｅｐａｒｔｍｅｎｔｏｆＤｅｒｍａｔｏｌｏｇｙ，ＦｉｒｓｔＡｆｆｉｌｉａｔｅｄＨｏｓｐｉｔａｌｏｆＫｕｎｍｉｎｇＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ，Ｋｕｎｍｉｎｇ６５００３２，Ｃｈｉｎａ；２．ＬｉｗａＩｎｓｔｉｔｕｔｅｏｆＳｋｉｎＨｅａｌｔｈ，ＥａｓｔＣｈｉｎａＮｏｒｍａｌＵｎｉｖｅｒｓｉｔｙ，Ｓｈａｎｇｈａｉ２０００６２，Ｃｈｉｎａ）

［Ａｂｓｔｒａｃｔ］Ｔｈｅｓｋｉｎｂａｒｒｉｅｒｉｎａｂｒｏａｄｓｅｎｓｅｉｎｃｌｕｄｅｓｔｈｅｐｈｙｓｉｃａｌｂａｒｒｉｅｒ，ｎｅｕｒａｌｂａｒｒｉｅｒ，ｐｉｇｍｅｎｔｂａｒｒｉｅｒ，ａｎｄｉｍｍｕｎｅｂａｒｒｉｅｒ，ｗｈｉｌｅｔｈｅｓｋｉｎｂａｒｒｉｅｒｉｎａｎａｒｒｏｗｓｅｎｓｅｇｅｎｅｒａｌｌｙｒｅｆｅｒｓｔｏｔｈｅｅｐｉｄｅｒｍａｌｂａｒｒｉｅｒ. Ｐｒｅｖｉｏｕｓｓｔｕｄｉｅｓｈａｖｅｍａｉｎｌｙｆｏｃｕｓｅｄｏｎｔｈｅｓｔｒａｔｕｍｃｏｒｎｅｕｍ，ｎｅｇｌｅｃｔｉｎｇｂａｒｒｉｅｒｒｅｐａｉｒｉｎｏｔｈｅｒｅｐｉｄｅｒｍａｌｌａｙｅｒｓ. Ｒｅｃｅｎｔｓｔｕｄｉｅｓｈａｖｅｒｅｖｅａｌｅｄｔｈａｔｅｐｉｄｅｒｍａｌｂａｒｒｉｅｒｄａｍａｇｅｉｎｖａｒｉｏｕｓｄｅｒｍａｔｏｓｅｓａｎｄｓｋｉｎｃｏｎｄｉｔｉｏｎｓｉｎｖｏｌｖｅｓｎｏｔｏｎｌｙｔｈｅｓｔｒａｔｕｍｃｏｒｎｅｕｍｂｕｔａｌｓｏｔｈｅｓｔｒａｔｕｍｇｒａｎｕｌｏｓｕｍ，ｓｔｒａｔｕｍｓｐｉｎｏｓｕｍ，ａｎｄｓｔｒａｔｕｍｂａｓａｌｅ，ｗｉｔｈａｌｔｅｒａｔｉｏｎｓｉｎｔｈｅｃｏｒｎｉｆｉｅｄｅｎｖｅｌｏｐｅ，ｉｎｔｅｒｃｅｌｌｕｌａｒｌｉｐｉｄｓ，ａｎｄｔｉｇｈｔｊｕｎｃｔｉｏｎｐｒｏｔｅｉｎｓｂｅｉｎｇｋｅｙｃｏｎｔｒｉｂｕｔｉｎｇｆａｃｔｏｒｓ．Ｈｏｗｅｖｅｒ，ｓｙｓｔｅｍａｔｉｃｉｎｖｅｓｔｉｇａｔｉｏｎｓｉｎｔｏｔｈｅｄａｍａｇｅｍｅｃｈａｎｉｓｍｓａｎｄｔａｒｇｅｔｅｄｉｎｔｅｒｖｅｎｔｉｏｎｓｆｏｒｄｉｆｆｅｒｅｎｔｅｐｉｄｅｒｍａｌｂａｒｒｉｅｒｌａｙｅｒｓｒｅｍａｉｎｌａｃｋｉｎｇ. Ｔｈｉｓａｒｔｉｃｌｅｐｒｏｐｏｓｅｓｔｈｅｎｅｗｃｏｎｃｅｐｔｏｆ “ ｅｐｉｄｅｒｍａｌｂａｒｒｉｅｒｄａｍａｇｅａｎｄｓｔｒａｔｉｆｉｅｄｒｅｐａｉｒ ”，ｐｒｏｖｉｄｉｎｇｂｏｔｈａｔｈｅｏｒｅｔｉｃａｌｆｒａｍｅｗｏｒｋａｎｄｎｅｗｃｌｉｎｉｃａｌｉｎｓｉｇｈｔｓｆｏｒｌａｙｅｒ⁃ｓｐｅｃｉｆｉｃｐｒｅｃｉｓｉｏｎｒｅｐａｉｒｏｆｔｈｅｅｐｉｄｅｒｍａｌｂａｒｒｉｅｒ.

［Ｋｅｙｗｏｒｄｓ］Ｓｋｉｎｂａｒｒｉｅｒ；Ｅｐｉｄｅｒｍａｌｂａｒｒｉｅｒ；Ｂａｒｒｉｅｒｒｅｐａｉｒ；Ｔｉｇｈｔｊｕｎｃｔｉｏｎｐｒｏｔｅｉｎｓ

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

Role of Vitamin C in Skin Diseases

Screening method and metabolic analysis of plant anti-aging microorganisms via ammoniainduced senescence in the duckweed Wolffia microscopica

Identification of Flavoanoids From Finger Citron and Evaluation on Their Antioxidative and Antiaging Activities

Exploring Greek actinobacterial biodiversity for the discovery of bioactive metabolites with skin antiaging potential

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Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

Role of Vitamin C in Skin Diseases

Screening method and metabolic analysis of plant anti-aging microorganisms via ammoniainduced senescence in the duckweed Wolffia microscopica

Identification of Flavoanoids From Finger Citron and Evaluation on Their Antioxidative and Antiaging Activities

Exploring Greek actinobacterial biodiversity for the discovery of bioactive metabolites with skin antiaging potential

消息订阅

学术会议

伤口世界提示