The state of the art in anti-aging: plant-based phytochemicals for skin care

Merve Tomas1 , Deniz Günal-Köroğlu1 , Senem Kamiloglu2,3, Tugba Ozdal4 and Esra Capanoglu1,5*

*Correspondence: Esra Capanoglu 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

1 Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Türkiye

2 Department of Food Engineering, Faculty of Agriculture, Bursa Uludag University, 16059 Gorukle, Bursa, Türkiye

3 Science and Technology Application and Research Center (BITUAM), Bursa Uludag University, 16059 Gorukle, Bursa, Türkiye

4 Department of Food Engineering, Faculty of Engineering and Natural Sciences, Istanbul Okan University, 34959 Tuzla, Istanbul, Türkiye

5 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China

Abstract

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin’s structural integrity. Carotenoids, vitamins, essential fatty acids, and phenolic compounds work by acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, and elastase, which degrade skin structure, and reducing levels of inflammatory markers (IL-6, IL-8, etc.) and matrix metalloproteinases (MMP-1, MMP- 2) linked to aging. Recent research highlights that plant-based phytochemicals can improve skin elasticity, reduce hyperpigmentation, prevent the breakdown of important skin proteins, and support wound healing, making them valuable components for skin care and treatments. This review explores the multifaceted roles of phytochemicals in maintaining and improving skin health, highlighting their mechanisms of action and potential in skin anti-aging

Keywords Skin care, Anti-aging, Phytochemicals, Polyphenols, Carotenoids, Fatty acids, Saponins, Alkoloids

次氯酸消毒液联合湿性愈合方法 用于慢性伤口疗效观察

封红伟 陈丽琴 胡绣华

DOI：10.3969/j.issn.0253-9926.2020.21.004

基金项目：上海市宝山区科学技术委员会科技创新专

项资金项目(17-E-8)

作者单位：200940 上海市第一人民医院宝山分院护理

部

【摘 要】 目的 观察次氯酸消毒液联合湿性愈合方法在慢性伤口中的效果。方法 对 2017 年 1 月至 2019 年 5 月在我院伤口门诊就诊慢性伤口患者(150 例 229 处伤口)，采用随机数字表格法分为观察组(75 例 116 处伤口)，采用次氯酸消毒液联合湿性愈合方法；对照组(75 例 113 处伤口)，采用常规湿性换药方法。比较 2 组患者创面愈合率、愈合时间、换药次数。 结果 观察组的伤口愈合率高于对照组，愈合时间、换药次数均少于对照组，差异有统计学意义(P<0．05)。结论 应用次氯酸消毒液联合湿性愈合方法优于常规湿性愈合方法。

【关键词】 次氯酸；消毒药；伤口愈合

Observation on the curative effect of hypochlorite disinfectant combined with wet healing on chronic wounds

Feng Hongwei, Chen Liqin, Hu Xiuhua．Department of Nursing， Baoshan Branch of Shanghai First People′s Hospital，Shanghai 200940， China

【Abstract】 Objective

To observe the effect of hypochlorite disinfectant combined with wet healing on chronic wounds．

Methods

From January 2017 to May 2019 229 wounds in 150 patients with chronic wounds were randomly divided into two groups： the observation group (116 wounds in 75 patients) of using combination of hypochlorite disinfectant and wet healing method and the control group (113 wounds in 75 patients) of using conventional wet healing method． Wound healing rate， healing time and dressing change times between the two groups were compared． Results The wound healing rate of the observation group was higher than that of the control group (P < 0．05)， and the healing time and dressing change times of the observation group were also lower than those of the conventional group (P< 0．05)． Conclusion

The combination of hypochlorite disinfectant and wet healing method is better than the conven

tional wet healing method．

【Key words】 Hypochlorous acid； Disinfectants； Wound healing

DOI：10.3969/j.issn.0253-9926.2020.21.004

WOUND INFECTIONINCLINICAL PRACTICEPrinciples of best practice

This article is excerpted from the INTERNATIONAL CONSENSUS UPDATE 2022 by Wound World.

次氯酸在伤口护理中的应用研究进展

王昳娜 1 ，何振华 1* ，周 瑾 1 ，孙晓芬 2

1. 绍兴文理学院元培学院，浙江 312000；2.浙江中医药大学附属第二医院

Research progress on the application of hypochlorous acid in wound care WANG Yi'na,HE Zhenhua,ZHOU Jin,SUN Xiaofen Shaoxing University,Yuanpei College,Zhejiang 312000 China Keywords hypochlorous acid solution；wound；infection；bacterial biofilm；clinical application；review

摘要

介绍了次氯酸溶液的发展史、杀菌机制、特点、与其他伤口清洁消毒剂的比较、使用方法以及当前研究的不足，旨在为次氯酸溶液在伤口治疗、护理中的应用提供依据。

关键词

次氯酸溶液；伤口；感染；细菌生物膜；临床应用；综述

doi:10. 12102/j. issn. 1009-6493. 2021. 16. 016

Consensus on Wound Antisepsis: Update 2018

Axel Kramer a Joachim Dissemond c Simon Kim b Christian Willy d Dieter Mayer e Roald Papke a Felix Tuchmann f Ojan Assadian g

a Institute of Hygiene and Environmental Medicine and b Department of Trauma, Reconstructive Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald , c Department of Dermatology, Venerology and Allergology, University Hospital Essen, Essen , and d Department of Trauma Surgery, Orthopedics, Reconstructive, Plastic and Hand Surgery, Bundeswehr Hospital, Berlin , Germany; e Department of Surgery, Kantonsspital Freiburg, Freiburg , Switzerland; f Department of Dermatology and g Department of Infection Control and Hospital Epidemiology, Medical University of Vienna, Vienna General Hospital, Vienna , Austria

Keywords

Wound antisepsis · Wounds-at-Risk Score · Antiseptics · Drug · Medical device · Octenidine · Polihexanide · Hypochlorite · Iodophors · Taurolidine · Silver ions · Acetic acid · Negative pressure wound therapy with the instillation of antiseptics · Physical body warm atmospheric plasma · Silver sulfadiazine · Dyes · Mercury compounds · Hydrogen peroxide

Antiaging Potential of Lipophilic Extracts of Caulerpa prolifera

Gonçalo P. Rosa 1,2 , Maria Carmo Barreto 1 , Ana M. L. Seca 1,2 and Diana C. G. A. Pinto 2,*

1 University of the Azores, Faculty of Sciences and Technology, Centre for Ecology, Evolution and Environmental Changes (cE3c), Azorean Biodiversity Group & Global Change and Sustainability Institute (CHANGE), 9501-321 Ponta Delgada, Portugal; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (G.P.R.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (M.C.B.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.M.L.S.)

2 LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Academic Editor: Charlotte Jacobsen

Received: 26 December 2024

Revised: 3 February 2025

Accepted: 11 February 2025

Published: 14 February 2025

Citation: Rosa, G.P.; Barreto, M.C.; Seca, A.M.L.; Pinto, D.C.G.A. Antiaging Potential of Lipophilic Extracts of Caulerpa prolifera. Mar.

Drugs 2025, 23, 83. https:// doi.org/10.3390/md23020083

Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

(https://creativecommons.org/ licenses/by/4.0/).

Abstract: The cosmeceutical industry has increasingly turned its attention to marine macroalgae, recognizing their significant bioactive potential as sources of natural compounds for skincare applications. A growing number of products now incorporate extracts or isolated compounds from various macroalgae species. However, many species remain underexplored, highlighting a valuable opportunity for further research. Among these, Caulerpa prolifera (Forsskål) J.V. Lamouroux has emerged as a promising candidate for cosmeceutical applications. This study provides the most comprehensive phytochemical assessment of C. prolifera to date, revealing its potential as a source of bioactive extracts and compounds. The analysis identified key components of its lipophilic profile, predominantly saturated and unsaturated fatty acids, alongside di-(2-ethylhexyl) phthalate—an endocrine disruptor potentially biosynthesized or bioaccumulated by the algae. While the crude extract exhibited moderate tyrosinase inhibitory activity, its overall antioxidant capacity was limited. Fractionation of the extract, however, yielded subfractions with distinct bioactivities linked to changes in chemical composition. Notably, enhanced inhibitory activities against elastase and collagenase were observed in subfractions enriched with 1-octadecanol and only traces of phthalate. Conversely, antioxidant activity diminished with the loss of specific compounds such as β-sitosterol, erucic acid, nervonic acid, and lignoceric acid. This work advances the understanding of the relationship between the chemical composition of C. prolifera and its bioactivities, emphasizing its potential as a source of cosmeceutical ingredients, leading to a more comprehensive valorization of this macroalga.

Keywords: macroalgae; phytochemical profile; cosmeceutical potential