伤口世界

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星期四, 07 11月 2019

EMPIRICAL STUDIES Comparison of 3-dimensional Wound Measurement With Laser-assisted and Hand Measurements: A Retrospective Chart Review

Authors

Evan S. Darwin

Jose A. Jaller

星期四, 07 11月 2019

CHILDREN WITH WOUNDS: ASKING THE RIGHT QUESTIONS Issues in Pediatric Wound Care

Authors

Vita Boyar

星期二, 05 11月 2019

LITERATURE REVIEW An Integrative Review of Depression in Patients Receiving Hemodialysis for End-stage Renal Disease and the Relevance to Patients With Wounds

Authors

Sheena A. Gagnier

星期二, 05 11月 2019

EMPIRICAL STUDIES A Descriptive Study of Hospital- and Community-acquired Pressure Ulcers/Injuries

Authors

Holly Kirkland-Kyhn

Oleg Teleten

星期二, 05 11月 2019

EDITOR'S OPINION Medical Communications and Disclosures: A Persistent Problem We Need to Fix

Authors

Lia van Rijswijk

星期二, 05 11月 2019

BACK TO BASICS Clean It Like You Mean It!

Authors

Dot Weir

K2 Content

Cordyceps militaris-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology 2025-05-13 00:00

Trung Quang Nguyen 1 , Thinh Van Pham 2 , Yusuf Andriana 3 and Minh Ngoc Truong 4,5,*

1 Institute of Environmental Science and Public Health, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi 11353, Vietnam; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Faculty of Tourism and Culinary, Ho Chi Minh City University of Industry and Trade, Ho Chi Minh City 70000, Vietnam; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

3 Research Center for Appropriate Technology, Indonesian Institute of Sciences, Subang 41213, Indonesia; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

4 Center for High Technology Research and Development, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi 100000, Vietnam

5 Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi 100000, Vietnam

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Academic Editor: Shige Wang

Received: 9 December 2024

Revised: 23 December 2024

Accepted: 25 December 2024

Published: 3 January 2025

Citation: Nguyen, T.Q.; Van Pham, T.; Andriana, Y.; Truong, M.N. Cordyceps militaris-Derived Bioactive Gels:

Therapeutic and Anti-Aging Applications in Dermatology. Gels 2025, 11, 33. https://doi.org/ 10.3390/gels11010033

Copyright: © 2025 by the authors.

Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).

Abstract: Cordyceps militaris is a medicinal mushroom widely utilized in traditional East Asian medicine, recognized for its diverse therapeutic properties. This review explores the potential of C. militaris-derived bioactive gels for applications in dermatology and skincare, with a particular focus on their therapeutic and anti-aging benefits. In response to the rising incidence of skin cancers and the growing demand for natural bioactive ingredients, C. militaris has emerged as a valuable source of functional compounds, including cordycepin, polysaccharides, and adenosine. These compounds exhibit multiple bioactivities, including apoptosis induction, cell cycle arrest, and anti-inflammatory effects, which have been shown to be particularly effective against melanoma and other skin cancers. Additionally, the antioxidant properties of C. militaris enhance skin resilience by scavenging reactive oxygen species, reducing oxidative stress, and promoting collagen synthesis, thereby addressing skin health and anti-aging requirements. The potential for incorporating C. militaris compounds into gel-based formulations for skincare is also ex amined, either as standalone bioactives or in combination with synergistic ingredients. Emphasis is placed on the necessity of clinical trials and standardization to establish the safety, efficacy, and reproducibility of such applications. By providing a safer alternative to synthetic agents, C. militaris-derived bioactive gels represent a promising advancement in dermatology and skincare.

Keywords: anti-aging; bioactive compounds; Cordyceps militaris; dermatology; skincare; therapeutic properties
Investigation of the anti-skin aging effects of taurine through mendelian randomization analysis of its relationship with immune cells 2025-05-12 00:00

Hongtao Liu, MD1 | Honglai Zheng, MD1 | Siyuan Zhou, MD2 | Quan Lin, MD3

1 Guangxi Health Science College, Nanning, China

2 The Second Affiliated Hospital of Guangxi Medical University, Nanning, China

3 The People's Hospital of Laibin, Laibin, China

Hongtao Liu and Honglai Zheng contributed equally to this work.

Correspondence

Quan Lin, The People's Hospital of Laibin, Laibin 546100, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

[Correction added on 26 August 2024, after first online publication:The spelling of the second author’s surname has been corrected in this version.]

Abstract

Background: Aging skin, exacerbated by external factors like UV radiation and pollutants, is a major cosmetic concern. Taurine, renowned for its antioxidant and anti-inflammatory properties, may combat skin aging. We performed mendelian randomization (MR) analysis to investigate the causal link between taurine and immune cells linked to skin aging.

Objectives: To investigate the association between taurine and immune cells using mendelian randomization, to thereby explore the mechanism through which taurine exerts anti-aging effects on the skin via immune modulation.

Methods: A MR approach was employed using taurine-level data from the Ieu Open GWAS Project and immunocyte traits from a large European cohort. MR-Egger regression, weighted median estimation, and inverse variance weighting all provided statistical insights into causality. Sensitivity analyses assessed the heterogeneity and pleiotropy among the genetic instruments used.

Results: MR analysis identified a causal relationship between taurine levels and 10 immunocyte phenotypes, with taurine found to be negatively and positively associated with three and seven phenotypes, respectively. Sensitivity analysis revealed no significant heterogeneity or pleiotropy, suggesting reliable MR findings.

Conclusion: This study provides insights into the immunological pathways by which taurine contributes to skin anti-aging effects, suggesting that increasing taurine levels could offer a novel strategy for anti-aging skincare.

KEYWORDS

anti-aging treatment, immune cells, Mendelian randomization, monocytes, taurine
Anti-Aging Effects of Flavonoids from Plant Extracts 2025-05-08 00:00

Bogdan Păcularu-Burada 1,2 , Alexandru-Ionut, Cîrîc 3,* and Mihaela Begea 3

1 ICA Research & Development S.R.L., 202 Splaiul Independent,ei, 060021 Bucharest, Romania; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Dan Voiculescu Foundation for the Development of Romania, 011885 Bucharest, Romania

3 Faculty of Biotechnical Systems Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independent,ei, 060042 Bucharest, Romania; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Citation: Păcularu-Burada, B.; Cîrîc, A.-I.; Begea, M. Anti-Aging Effects of Flavonoids from Plant Extracts. Foods

2024, 13, 2441. https://doi.org/ 10.3390/foods13152441

Academic Editor: Barry Parsons

Received: 4 July 2024

Revised: 25 July 2024

Accepted: 29 July 2024

Published: 2 August 2024

Copyright: © 2024 by the authors.

Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Abstract: Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues’ and cells’ morphology and functionality and consequently being responsible for aging-related diseases. Taking into account the actual preoccupations of both consumers and researchers, healthy anti-aging alternatives are being intensively studied in order to address such concerns. Due to their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights the possibilities to use flavonoids extracted from various plants for their antiaging potential on the skin, brain, and heart. Moreover, their anticarcinogenic, anti-inflammatory, and anti-diabetic properties are summarized, along with the senescence-associated mechanisms. Both the nutraceutical and cosmeceutical fields are continuously developing and flavonoids originating from plants are promising candidates to obtain such products. Thus, the bioactive compounds’ extraction and their subsequent involvement in innovative product manufacturing must be carefully performed while being aware of the various intrinsic and extrinsic factors that may affect the phytochemicals’ structures, bioavailability, and health effects.

Keywords: flavonoids; senescence; diseases; anti-aging; nutraceuticals

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

EMPIRICAL STUDIES Comparison of 3-dimensional Wound Measurement With Laser-assisted and Hand Measurements: A Retrospective Chart Review

CHILDREN WITH WOUNDS: ASKING THE RIGHT QUESTIONS Issues in Pediatric Wound Care

LITERATURE REVIEW An Integrative Review of Depression in Patients Receiving Hemodialysis for End-stage Renal Disease and the Relevance to Patients With Wounds

EMPIRICAL STUDIES A Descriptive Study of Hospital- and Community-acquired Pressure Ulcers/Injuries

EDITOR'S OPINION Medical Communications and Disclosures: A Persistent Problem We Need to Fix

BACK TO BASICS Clean It Like You Mean It!

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

EMPIRICAL STUDIES Comparison of 3-dimensional Wound Measurement With Laser-assisted and Hand Measurements: A Retrospective Chart Review

CHILDREN WITH WOUNDS: ASKING THE RIGHT QUESTIONS Issues in Pediatric Wound Care

LITERATURE REVIEW An Integrative Review of Depression in Patients Receiving Hemodialysis for End-stage Renal Disease and the Relevance to Patients With Wounds

EMPIRICAL STUDIES A Descriptive Study of Hospital- and Community-acquired Pressure Ulcers/Injuries

EDITOR'S OPINION Medical Communications and Disclosures: A Persistent Problem We Need to Fix

BACK TO BASICS Clean It Like You Mean It!

消息订阅

学术会议

伤口世界提示