Hongtao Liu, MD1 | Honglai Zheng, MD1 | Siyuan Zhou, MD2 | Quan Lin, MD3
1 Guangxi Health Science College, Nanning, China
2 The Second Affiliated Hospital of Guangxi Medical University, Nanning, China
3 The People's Hospital of Laibin, Laibin, China
Hongtao Liu and Honglai Zheng contributed equally to this work.
Correspondence
Quan Lin, The People's Hospital of Laibin, Laibin 546100, China.
Email: linquanjg@163.com
[Correction added on 26 August 2024, after first online publication:The spelling of the second author’s surname has been corrected in this version.]
Abstract
Background: Aging skin, exacerbated by external factors like UV radiation and pollutants, is a major cosmetic concern. Taurine, renowned for its antioxidant and anti-inflammatory properties, may combat skin aging. We performed mendelian randomization (MR) analysis to investigate the causal link between taurine and immune cells linked to skin aging.
Objectives: To investigate the association between taurine and immune cells using mendelian randomization, to thereby explore the mechanism through which taurine exerts anti-aging effects on the skin via immune modulation.
Methods: A MR approach was employed using taurine-level data from the Ieu Open GWAS Project and immunocyte traits from a large European cohort. MR-Egger regression, weighted median estimation, and inverse variance weighting all provided statistical insights into causality. Sensitivity analyses assessed the heterogeneity and pleiotropy among the genetic instruments used.
Results: MR analysis identified a causal relationship between taurine levels and 10 immunocyte phenotypes, with taurine found to be negatively and positively associated with three and seven phenotypes, respectively. Sensitivity analysis revealed no significant heterogeneity or pleiotropy, suggesting reliable MR findings.
Conclusion: This study provides insights into the immunological pathways by which taurine contributes to skin anti-aging effects, suggesting that increasing taurine levels could offer a novel strategy for anti-aging skincare.
KEYWORDS
anti-aging treatment, immune cells, Mendelian randomization, monocytes, taurine
Bogdan Păcularu-Burada 1,2 , Alexandru-Ionut, Cîrîc 3,* and Mihaela Begea 3
1 ICA Research & Development S.R.L., 202 Splaiul Independent,ei, 060021 Bucharest, Romania; bogdan.pacularu@ica-rd.ro
2 Dan Voiculescu Foundation for the Development of Romania, 011885 Bucharest, Romania
3 Faculty of Biotechnical Systems Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independent,ei, 060042 Bucharest, Romania; mihaela.begea@upb.ro
* Correspondence: alexandru.ciric@upb.ro
Citation: Păcularu-Burada, B.; Cîrîc, A.-I.; Begea, M. Anti-Aging Effects of Flavonoids from Plant Extracts. Foods
2024, 13, 2441. https://doi.org/ 10.3390/foods13152441
Academic Editor: Barry Parsons
Received: 4 July 2024
Revised: 25 July 2024
Accepted: 29 July 2024
Published: 2 August 2024
Copyright: © 2024 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Abstract: Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues’ and cells’ morphology and functionality and consequently being responsible for aging-related diseases. Taking into account the actual preoccupations of both consumers and researchers, healthy anti-aging alternatives are being intensively studied in order to address such concerns. Due to their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights the possibilities to use flavonoids extracted from various plants for their antiaging potential on the skin, brain, and heart. Moreover, their anticarcinogenic, anti-inflammatory, and anti-diabetic properties are summarized, along with the senescence-associated mechanisms. Both the nutraceutical and cosmeceutical fields are continuously developing and flavonoids originating from plants are promising candidates to obtain such products. Thus, the bioactive compounds’ extraction and their subsequent involvement in innovative product manufacturing must be carefully performed while being aware of the various intrinsic and extrinsic factors that may affect the phytochemicals’ structures, bioavailability, and health effects.
Keywords: flavonoids; senescence; diseases; anti-aging; nutraceuticals
Authors
Daniela Tinti Moreira Borges
Leila Blanes
Rebecca Bryan
Janice M. Beitz
Gözde Turkmenoglu
Ayise Karadag
Ruud J.G. Halfens
Jeen R.E. Haalboom
Daniel R. Baillie
Peter Stawicki
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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