伤口世界

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星期四, 17 10月 2019

患胆结石的母子二人，胆囊切除后的生活质量变化竟然是？

胡海涛负压引流与创面修复

母，54岁，反复右上腹疼痛10年，再发2周，当地医院诊断1.胆囊结石慢性胆囊炎 2.胆总管结石 3.急性胰腺炎，建议开刀手术：胆囊切除+胆总管切开取石，为微创手术就诊我院，先ERCP取胆总管结石时发现胃潴留、十二指肠狭窄，于2016年6月24日行腹腔镜下胆囊切除+胆总管切开取石+一期胆总管缝合+胃大部切除+毕二胃空肠吻合术，术后第9天痊愈出院。

星期四, 17 10月 2019

我们从洗脚开始，1月治愈94岁婆婆两年的烂脚！

胡海涛负压引流与创面修复

简介：霍婆婆，94岁，右足背溃烂2年，曾在多家医院诊治，未愈，2018-3-9就诊我院：

星期四, 17 10月 2019

急诊外科轮转那年的儿童节，用完备用的小手术包！

原创：胡海涛负压引流与创面修复

几年前，急诊科值夜班，17：00接班，刚坐下不久，小儿外伤接踵而至，一直忙到23：00，用完所有小手术包后，才吃晚饭！

星期四, 17 10月 2019

震惊：胆囊结石患者，吃排石药，吃到肝衰竭致死亡！

原创：胡大夫负压引流与创面修复

今天和省人民医院朋友聊天，关于吃药‘偏方’‘秘方’等等的后遗症，没有最惨，只有更惨！

星期四, 17 10月 2019

糖尿病腹泻，可能的原因是哪些？

胡海涛负压引流与创面修复

糖尿病腹泻难治疗，原因是它的病因太复查，dxy战友总结若下几点：

星期四, 17 10月 2019

痛风石导致畸形的手，居然可以恢复功能！

原创：胡大夫负压引流与创面修复

老年女患，65岁，双手痛风性关节炎并急性发作，高热、疼痛剧烈，入院时尿酸580umol/L.

K2 Content

Efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms 2024-11-27 00:00

Xianghua Zhang1 Delphine Kerob2 Zhongxing Zhang1 Han Tao1 Xiaofeng He3 Yi Yi3 Xiaofeng Fang3 Wenna Wang3 Andrew Steel3

1 L’Oreal Dermatological Beauty, L’Oréal China, Shanghai, China

2 La Roche-Posay Laboratoire Pharmaceutique, Levallois Perret, La Roche-Posay, France

3 Research and Innovation Center, L’Oréal China, Shanghai, China

Correspondence

Xianghua Zhang, L’Oreal Dermatological Beauty, L’Oréal China, Shanghai, China.

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Abstract

Background: Sensitive skin is a common condition affecting a significant proportion of the population, and there is a growing demand for effective and safe management.

Aim: To evaluate the efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate as an optimal care for facial sensitive skin.

Methods: A total of 110 participants (64 in group A and 46 in group B) with facial sensitive skin applied the cream twice daily for 28 days. Group A evaluated their sensitive skin, product efficacy, and product use experience at D0 (15 min), D1, D14, and D28. In group B, skin barrier function-related indicators were measured at baseline and on D1, D7, D14, and D28. Dermatologists evaluated tolerance for all participants.

Results: After 28 days of use, in group A, 100% of participants reported mildness and comfort with product use. Participants demonstrated significant improvements in skin barrier function-related indicators, including increased stratum corneum moisture content, reduced erythema index, elevated sebum content, decreased trans-epidermal water loss, and diminished skin redness parameter a* value (all p < 0.05). Dermatologist evaluations revealed excellent tolerance among all participants.

Conclusion: The panthenol-enriched cream with prebiotics and probiotic lysate exhibited substantial clinical efficacy in ameliorating facial sensitive skin conditions, coupled with a high safety profile.

KEYWORDS panthenol, prebiotics, probiotics, sensitive skin, skin barrier function
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study 2024-11-26 00:00

Marta Arnal‑Forné1 · Tamara Molina‑García2 · María Ortega2 · Víctor Marcos‑Garcés2,3 · Pilar Molina4 · Antonio Ferrández‑Izquierdo1,2,5 · Pilar Sepulveda1,6,7 · Vicente Bodí2,3,6,8 · César Ríos‑Navarro1,2,6 · Amparo Ruiz‑Saurí1,2,6

Accepted: 10 June 2024 / Published online: 2 July 2024

© The Author(s) 2024

Abstract

Skin represents the main barrier against the external environment, but also plays a role in human relations, as one of the prime determinants of beauty, resulting in a high consumer demand for skincare-related pharmaceutical products. Given the importance of skin aging in both medical and social spheres, the present research aims to characterize microscopic changes in human skin composition due to intrinsic aging (as opposed to aging infuenced by external factors) via histological analysis of a photoprotected body region. Samples from 25 autopsies were taken from the periumbilical area and classifed into four age groups: group 1 (0–12 years), group 2 (13–25 years), group 3 (26–54 years), and group 4 (≥55 years). Diferent traditional histological (hematoxylin–eosin, Masson’s trichrome, orcein, toluidine, Alcian blue, and Feulgen reaction) and immunohistochemical (CK20, CD1a, Ki67, and CD31) stains were performed. A total of 1879 images photographed with a Leica DM3000 optical microscope were morphometrically analyzed using Image ProPlus 7.0 for further statistical analysis with GraphPad 9.0. Our results showed a reduction in epidermis thickness, interdigitation and mitotic indexes, while melanocyte count was raised. Papillary but not reticular dermis showed increased thickness with aging. Specifcally, in the papillary layer mast cells and glycosaminoglycans were expanded, whereas the reticular dermis displayed a diminution in glycosaminoglycans and elastic fbers. Moreover, total cellularity and vascularization of both dermises were diminished with aging. This morphometric analysis of photoprotected areas reveals that intrinsic aging signifcantly infuences human skin composition. This study paves the way for further research into the molecular basis underpinning these alterations, and into potential antiaging strategies.

Keywords Skin aging · Intrinsic aging · Morphometric analysis · Human biopsies

César Ríos-Navarro

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* Amparo Ruiz-Saurí 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

1 Department of Pathology, University of Valencia, Avda. Blasco Ibáñez 15. 46010, Valencia, Spain

2 Instituto de Investigación Sanitaria INCLIVA Biomedical Research Institute, Avda. Menéndez Pelayo 4acc,

46010 Valencia, Spain

3 Cardiology Department, Hospital Clínico Universitario, Valencia, Spain

4 Department of Pathology, Instituto de Medicina Legal y Ciencias Forenses, Valencia, Spain

5 Anatomic Pathology Department, Hospital Clínico Universitario, Valencia, Spain

6 Centro de Investigación Biomédica en Red (CIBER)-CV, Madrid, Spain

7 Regenerative Medicine and Heart Transplantation Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain

8 Department of Medicine, University of Valencia, Valencia, Spain
An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair 2024-11-25 00:00

Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5

1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea

2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea

4 UltraV Co., Ltd. R&D Center, Seoul, South Korea

5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea

Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

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Abstract

Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.

Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.

Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.

Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.

KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

患胆结石的母子二人，胆囊切除后的生活质量变化竟然是？

我们从洗脚开始，1月治愈94岁婆婆两年的烂脚！

急诊外科轮转那年的儿童节，用完备用的小手术包！

震惊：胆囊结石患者，吃排石药，吃到肝衰竭致死亡！

糖尿病腹泻，可能的原因是哪些？

痛风石导致畸形的手，居然可以恢复功能！

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

患胆结石的母子二人，胆囊切除后的生活质量变化竟然是？

我们从洗脚开始，1月治愈94岁婆婆两年的烂脚！

急诊外科轮转那年的儿童节，用完备用的小手术包！

震惊：胆囊结石患者，吃排石药，吃到肝衰竭致死亡！

糖尿病腹泻，可能的原因是哪些？

痛风石导致畸形的手，居然可以恢复功能！

消息订阅

学术会议

伤口世界提示