Xiaoqian Liu,1,5,6,7,21 Zunpeng Liu,1,5,7,21 Zeming Wu,2,5,7,21 Jie Ren,3,5,7,21 Yanling Fan,3,7 Liang Sun,9 Gang Cao,8 Yuyu Niu,11,12,13 Baohu Zhang,1,7 Qianzhao Ji,2,7 Xiaoyu Jiang,2,7 Cui Wang,3,7 Qiaoran Wang,3,7 Zhejun Ji,1,5,7 Lanzhu Li,2,7 Concepcion Rodriguez Esteban,18 Kaowen Yan,2,5,7 Wei Li,4 Yusheng Cai,2,5,7 Si Wang,4,5,7,15,16 Aihua Zheng,7,19 Yong E. Zhang,7,14 Shengjun Tan,14 Yingao Cai,7,14 Moshi Song,2,5,6,7 Falong Lu,7,10 Fuchou Tang,17 Weizhi Ji,11,12,20 Qi Zhou,1,5,6,7,20 Juan Carlos Izpisua Belmonte,18,20 Weiqi Zhang,3,5,7,* Jing Qu,1,5,6,7,* and Guang-Hui Liu2,4,5,6,7,22,*
1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2 State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
3 CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China
4 Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China
5 Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
6 Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
7 University of Chinese Academy of Sciences, Beijing 100049, China
8 State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
9 NHC Beijing Institute of Geriatrics, NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine of Chinese Academy of Medical Sciences, National Center of Gerontology/Beijing Hospital, Beijing 100730, China
10 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China
11 State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China
12 Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650500, China
13 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China
14 Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
15 Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China
16 The Fifth People’s Hospital of Chongqing, Chongqing 400062, China
17 Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
18 Altos Labs, Inc., San Diego, CA 94022, USA
19 State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
20 Senior author
21 These authors contributed equally
22 Lead contact
*Correspondence: zhangwq@big.ac.cn (W.Z.), qujing@ioz.ac.cn (J.Q.), ghliu@ioz.ac.cn (G.-H.L.)
https://doi.org/10.1016/j.cell.2022.12.017
SUMMARY
Whether and how certain transposable elements with viral origins, such as endogenous retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the aging process is largely unknown. In human senescent cells, we found that HERVK (HML-2), the most recently integrated human ERVs, are unlocked to transcribe viral genes and produce retrovirus-like particles (RVLPs). These HERVK RVLPs constitute a transmissible message to elicit senescence phenotypes in young cells, which can be blocked by neutralizing antibodies. The activation of ERVs was also observed in organs of aged primates and mice as well as in human tissues and serum from the elderly. Their repression alleviates cellular senescence and tissue degeneration and, to some extent, organismal aging. These findings indicate that the resurrection of ERVs is a hallmark and driving force of cellular senescence and tissue aging.
伤口、造口、失禁护理俱乐部
伤口、造口、失禁护理俱乐部 以下文章来源于造口全优管理 ,作者康乐保中国
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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