伤口世界

电子邮件地址: michael.kung@139.com

星期三, 04 9月 2019

一张图让你了解糖尿病到底是什么？

体外诊断网中诺医疗

如果把人的身体比作

一家大公司

里面有好多部门

每个部门的正常运作

确保公司得以健康发展

星期三, 04 9月 2019

健康教育视频：呼吸训练器（三球仪）的使用方法

原创：中诺医疗中诺医疗

呼吸训练器（三球仪）是集阻力呼吸、缩唇呼吸、容量锻炼和耐力训练于一体的训练工具，适用于对抗衰老、预防和治疗疾病，如心、胸、腹、盆部等手术前后、机械通气后、ICU、脑损伤神经肌肉功能障碍、面瘫、吞咽功能障碍、长期吸烟、COPD、胸廓畸形和长期卧床等。呼吸训练器（三球仪）在国外发达国家普遍使用。

星期三, 04 9月 2019

你分得清什么是疤痕疙瘩？什么是疤痕增生？

中诺医疗

最近有不少疤友很着急的问小编：我的疤痕好像比以前更严重了，我这个是不是疤痕疙瘩啊？我是不是疤痕体质啊？

星期三, 04 9月 2019

疤痕带来的伤害，你真的了解吗？

去疤痕中诺医疗

疤痕形成的原因

在人体损伤后愈合的部位，皮肤上会留下不规则的凸起于表面，质硬的，或伴有疼痛、红、痒等不具备正常皮肤组织结构及生理功能的，失去正常组织活力的，异常的，不健全的组织即称为疤痕。疤痕是皮肤对创伤自我修复的产物。

星期三, 04 9月 2019

疤痕为什么总是“奇痒无比”？

去疤痕中诺医疗

当一个人受伤后，尤其是大面积烧烫伤后，受伤区域的疤痕可能会出现凸起并伴随瘙痒。

严重的瘙痒可以让病人寝食不安，痛苦不堪。那么，疤痕为什么会痒?可以治疗吗?

星期三, 04 9月 2019

【医学广角】湿性敷料的止痛原理

赫曼关爱健康中诺医疗

随着医护人员对伤口护理质量及病患生活质量追求的提高，敷料无痛更换及敷料的止痛效果正获得越来越多的重视。以往大家更多的关注敷料更换时的无痛、无二次损伤，随着新型敷料的使用逐渐增多，医护人员也需更加重视敷料贴附时的止痛效果。

K2 Content

Sustainable Skincare Innovation: Cork Powder Extracts as Active Ingredients for Skin Aging 2025-04-11 00:00

Ana Silva 1,2,† , Cláudia Pinto 3,4,†, Sara Cravo 3,4 , Sandra Mota 5,6 , Liliana Rego 5,6 , Smeera Ratanji 6,7 , Clara Quintas 6,7, Joana Rocha e Silva 8 , Carlos Afonso 3,4 , Maria Elizabeth Tiritan 3,4,9,10 , Honorina Cidade 3,4,10,* , Teresa Cruz 1,2,* and Isabel F. Almeida 5,6

1 Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; anacrs@cnc.uc.pt

2 CIBB—Center for Innovative Biomedicine and Biotechnology/CNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal

3 Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal; up201604041@ff.up.pt (C.P.); scravo@ff.up.pt (S.C.); cafonso@ff.up.pt (C.A.); beth@ff.up.pt (M.E.T.)

4 CIIMAR–Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal

5 UCIBIO—Applied Molecular Biosciences Unit, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal; up201608486@edu.ff.up.pt (S.M.); up201203377@edu.ff.up.pt (L.R.); ifalmeida@ff.up.pt (I.F.A.)

6 Associate Laboratory i4HB—Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal; up201805318@edu.ff.up.pt (S.R.); claraquintas@ff.up.pt (C.Q.)

7 UCIBIO—Applied Molecular Biosciences Unit, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal

8 Dimas & Silva, Lda. Industry, Rua Central de Goda 345, 4535-167 Mozelos, Portugal; joanasilva@dimas-silva.pt

9 TOXRUN—Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal 10 UNIPRO—Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (CESPU), 4585-116 Gandra, Portugal

* Correspondence: hcidade@ff.up.pt (H.C.); trosete@ff.uc.pt (T.C.)

† These authors equally contributed to this work.

Academic Editor: Chung-Yi Chen

Received: 18 December 2024

Revised: 11 January 2025

Accepted: 14 January 2025

Published: 17 January 2025

Citation: Silva, A.; Pinto, C.; Cravo, S.; Mota, S.; Rego, L.; Ratanji, S.; Quintas, C.; Silva, J.R.e.; Afonso, C.; Tiritan, M.E.; et al. Sustainable Skincare Innovation: Cork Powder

Extracts as Active Ingredients for Skin Aging. Pharmaceuticals 2025, 18, 121.

https://doi.org/10.3390/ ph18010121

Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

(https://creativecommons.org/ licenses/by/4.0/)

Abstract: Background: An emerging practice within the concept of circular beauty involves the upcycling of agro-industrial by-products. Cork processing, for instance, yields byproducts like cork powder, which presents an opportunity to create value-added cosmetic ingredients. Building upon our previous research, demonstrating the antioxidant potential of hydroalcoholic extracts derived from two distinct cork powders (P0 and P1), in this work, aqueous extracts were prepared and analyzed. The safety and bioactivities of the newly obtained aqueous extracts, as well as the 30% ethanol extracts, previously reported to be the most promising for skin application, were also evaluated.

Methods: Aqueous extracts were obtained from cork powders (P0 and P1) and the identification and quantification of some polyphenols was achieved by liquid chromatography (LC). Antioxidant potential was screened by DPPH method and the bioactivity and safety of extracts were further explored using cell-based assays.

Results: All extracts exhibited a reduction in age-related markers, including senescence-associated beta-galactosidase (SA-β-gal) activity. Additionally, they demonstrated a pronounced anti-inflammatory effect by suppressing the production of several pro-inflammatory mediators in macrophages upon lipopolysaccharide stimulation. Moreover, the extracts upregulated genes and proteins associated with antioxidant activity, such as heme oxygenase 1. The aqueous extract from P1 powder was especially active in reducing pro-inflammatory mediators, namely the Nos2 gene, inducible nitric oxide protein levels, and nitric oxide production. Moreover, it did not induce skin irritation, as assessed by the EpiSkin test, in compliance with the OECD Test Guidelines.

Conclusions: Overall, our findings underscore the potential of aqueous extracts derived from cork waste streams to mitigate various hallmarks of skin aging, including senescence and inflammaging, and their suitability for incorporation into cosmetics formulations. These results warrant further exploration for their application in the pharmaceutical and cosmetic industries and could foster a sustainable and circular bioeconomy.

Keywords: cosmetics; cork extracts; skin aging; sustainability; senescence; inflammaging; circular economy
Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond 2025-04-10 00:00

Lara Camillo, Elisa Zavattaro and Paola Savoia *

Department of Health Science, Università del Piemonte Orientale, 28100 Novara, Italy;

lara.camillo@uniupo.it (L.C.); elisa.zavattaro@med.uniupo.it (E.Z.)

* Correspondence: paola.savoia@med.uniupo.it; Tel.: +39-0321-373-3387

Academic Editor: Adam Reich

Received: 30 December 2024

Revised: 23 January 2025

Accepted: 27 January 2025

Published: 1 February 2025

Citation: Camillo, L.; Zavattaro, E.; Savoia, P. Nicotinamide: A

Multifaceted Molecule in Skin Health and Beyond. Medicina 2025, 61, 254.

https://doi.org/10.3390/ medicina61020254

Copyright: © 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/)

Abstract: Nicotinamide (NAM), the amide form of vitamin B3, is a precursor to essential cofactors nicotinamide adenine dinucleotide (NAD+ ) and NADPH. NAD+ is integral to numerous cellular processes, including metabolism regulation, ATP production, mitochondrial respiration, reactive oxygen species (ROS) management, DNA repair, cellular senescence, and aging. NAM supplementation has demonstrated efficacy in restoring cellular energy, repairing DNA damage, and inhibiting inflammation by suppressing proinflammatory cytokines release. Due to its natural presence in a variety of foods and its excellent safety profile—even at high doses of up to 3 g/day—NAM is extensively used in the chemoprevention of non-melanoma skin cancers and the treatment of dermatological conditions such as blistering diseases, atopic dermatitis, rosacea, and acne vulgaris. Recently, its anti-aging properties have elevated NAM’s prominence in skincare formulations. Beyond DNA repair and energy replenishment, NAM significantly impacts oxidative stress reduction, cell cycle regulation, and apoptosis modulation. Despite these multifaceted benefits, the comprehensive molecular mechanisms underlying NAM’s actions remain not fully elucidated. This review consolidates recent research to shed light on these mechanisms, emphasizing the critical role of NAM in cellular health and its therapeutic potential. By enhancing our understanding, this work underscores the importance of continued exploration into NAM’s applications, aiming to inform future clinical practices and skincare

Keywords: nicotinamide; chemoprevention; skin health; cellular oxidative stress; DNA damage; photoaging; ultraviolet radiation; inflammation; vitamin B3
Acheta domesticus: A Natural Source of Anti-Skin-Aging Ingredients for Cosmetic Applications 2025-04-09 00:00

Kankanit Yeerong 1 , Panuwan Chantawannakul 2 , Songyot Anuchapreeda 3,4 , Thomas Rades 5 ,

Anette Müllertz 5,6 and Wantida Chaiyana 1,4,7,*

1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand; kankanit_yeerong@cmu.ac.th

2 Bee Protection Laboratory, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand; panuwan.c@cmu.ac.th

3 Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand; songyot.anuch@cmu.ac.th

4 Center of Excellence in Pharmaceutical Nanotechnology, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand

5 Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark; thomas.rades@sund.ku.dk (T.R.); anette.mullertz@sund.ku.dk (A.M.)

6 Bioneer:FARMA, Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

7 Multidisciplinary and Interdisciplinary School, Chiang Mai University, Chiang Mai 50200, Thailand *

Correspondence: wantida.chaiyana@cmu.ac.th

Abstract: Acheta domesticus is an edible insect, rich in nutritional value and considered a sustainable protein source. This study aimed to investigate the potential application of A. domesticus extracts for anti-skin-aging purposes. The extracts were prepared by maceration at ambient temperature with 95% ethanol or hexane and maceration in gentle heat (45 ◦C) with 95% v/v ethanol or DI water. The extracts were examined for total protein, phenolic, and flavonoid contents. Protein molecular weight distribution was analyzed. The safety of the extracts was investigated in terms of irritation and cytotoxicity. Biological activities relevant to the inhibition of skin aging were evaluated, including increasing transforming growth factor-beta 1 (TGF-β1) expression and inhibitory activities on collagenase and hyaluronidase. The aqueous extract from maceration in gentle heat had the highest total protein content (63 ± 1% w/w), total phenolic content (0.48 ± 0.03 mg GAE/g extract), TGF-β1

stimulating activities (33 ± 2 pg/mL), and collagenase inhibition (with a half maximal inhibitory

concentration of 26 ± 1 µg/mL) among various extracts investigated. It caused no irritation to the

hen’s egg chorioallantoic membrane and showed no cytotoxicity to human dermal fibroblasts and

peripheral blood mononuclear cells. Therefore, aqueous A. domesticus extract is proposed as an

innovative natural anti-skin-aging ingredient.

Keywords: Acheta domesticus; anti-aging skincare; cosmetic; human dermal fibroblast; safety

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

一张图让你了解糖尿病到底是什么？

健康教育视频：呼吸训练器（三球仪）的使用方法

你分得清什么是疤痕疙瘩？什么是疤痕增生？

疤痕带来的伤害，你真的了解吗？

疤痕为什么总是“奇痒无比”？

【医学广角】湿性敷料的止痛原理

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

一张图让你了解糖尿病到底是什么？

健康教育视频：呼吸训练器（三球仪）的使用方法

你分得清什么是疤痕疙瘩？什么是疤痕增生？

疤痕带来的伤害，你真的了解吗？

疤痕为什么总是“奇痒无比”？

【医学广角】湿性敷料的止痛原理

消息订阅

学术会议

伤口世界提示