伤口世界

电子邮件地址: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

星期二, 03 9月 2019

糖尿病足：疾病、并发症或症状？

慢伤前沿中诺医疗

糖尿病是北美第六大死亡原因。糖尿病人中有25%会发生足溃疡，而足溃疡会显著增加截肢风险和死亡率。早期识别高危足和给予及时治疗可以挽救下肢和生命。多学科治疗方法对于支持患者需求至关重要。

星期二, 03 9月 2019

负压创面疗法联合浸银敷料治疗混合伤口的临床经验：50 例个案的回顾性研究

原创：中诺医疗

作者：

Peter Bukovcan, MD, PhD; Jan Koller, MD, PhD; Marianna Hajská, MD, PhD; and Peter

Záhorec, MD, PhD

关键词：

负压创面疗法

浸银敷料

伤口修复

星期二, 03 9月 2019

中国慢性难愈性创面诊疗思路及原则

转载中诺医疗

星期二, 03 9月 2019

每2个糖尿病足患者就有一人要截肢，这是危言耸听么？

转载中诺医疗

每6个糖尿病患者中

就有一人患糖尿病足

每2个糖尿病足患者中

就有一人要把腿截掉

这个数字或许更触目惊心

星期二, 03 9月 2019

体检报告怎么看？九图带你读懂

中诺医疗

保持健康，定期体检很重要！然而好不容易在人山人海中完成检查，拿到报告却一头雾水？尿酮体、胆固醇、甘油三酯……这些指标都是什么意思？出现升高或降低提示了怎样的身体变化？……九图带你看懂指标背后的健康信号↓↓发现异常情况要及时就医。转给你关心的TA！

星期二, 03 9月 2019

伤口清创流程

慢伤前沿中诺医疗

K2 Content

Protective Effects of Sesame Glycoproteins on Ultraviolet-Induced Skin Aging: In Vitro and In Vivo Studies 2025-04-08 00:00

Kyung Kyu Baik 1,†, Woo-Yong Song 2,†, Dong Keun Song 1 , Jaehyeok Yun 1 , Ji Hwan Jang 1 , Jae Young Oh 1 , Mi-Jin Lee 2 , Eunjandi Go 2 , Kyong Jin Lee 2 , Eunmiri Roh 3 and Jong-Eun Kim 1,*

1 Department of Food Science and Technology, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.K.B.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (D.K.S.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (J.Y.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (J.H.J.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (J.Y.O.)

2 CNABIOTECH Co., Ltd., Cheongju-si 28106, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (W.-Y.S.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (M.-J.L.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (E.G.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.J.L.)

3 Department of Cosmetic Science, Kwangju Women’s University, Gwangju 62396, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel.: +82-43-820-5245; Fax: +82-43-820-5240

† These authors contributed equally to this work

Abstract: Background/Objectives: Ultraviolet (UV) radiation is a primary factor in skin photoaging, leading to wrinkles, reduced elasticity, and pigmentation changes due to damage to cellular DNA, proteins, and lipids. Glycoproteins from sesame cake (SPE) have potential protective effects against UV-induced skin aging. This study investigated the anti-photoaging effects of SPE on UV-induced damage in human keratinocyte HaCaT cells and SKH-1 hairless mice. Methods: SPE was evaluated for its ability to mitigate UV-induced damage in HaCaT cells by assessing MMP-1 protein and mRNA expression levels, as well as the activity of transcription factors AP-1 and NF-κB. The phosphorylation of AKT and MAPK pathways was also analyzed. In vivo, SKH-1 hairless mice were exposed to UV radiation, and the effects of SPE on wrinkle formation and skin structure were assessed by measuring wrinkle length, area, and volume. Results: SPE significantly inhibited UV-induced MMP-1 protein and mRNA expression in HaCaT cells, indicating suppression of AP-1 and NF-κB transcription factors involved in MMP-1 production. Additionally, SPE reduced UV-induced phosphorylation of AKT and MAPK pathways. In SKH-1 hairless mice, SPE treatment led to significant reductions in wrinkle length, area, and volume, preserving skin structure in UV-exposed mice. Conclusions: The findings demonstrate that SPE has protective effects against UV-induced photoaging by inhibiting key molecular pathways associated with skin aging. SPE shows promise as a natural anti-photoaging agent, providing a foundation for future skincare product development. Further studies are warranted to explore the molecular mechanisms in detail and to validate these effects through clinical trials.

Keywords: sesame glycoproteins; ultraviolet; skin; aging
Effects of Hypochlorous Acid Solutions on Venous Leg Ulcers (VLU): Experience With 1249 VLUs in 897 Patients 2025-04-07 00:00

Cheryl M. Bongiovanni, PhD, RVT, CWS, FASA, FACCWSa,b, *

a Wound Clinics and Vascular Laboratories, Lake Health District, Lake District Hospital, 700 South J Street, Lakeview, OR 97630, USA; and

b Lake Wound Clinic – Klamath Falls, LLC, 2301 B Mountain View Boulevard, Klamath Falls, OR 97601, USA

KEYWORDS: Venous leg ulcer (VLU); Hypochlorous acid; Multidrug resistant infection
Betaine–salicylic acid cocrystal for enhanced skincare and acne treatment† 2025-04-03 00:00

Zhenyuan Wang,ab Mi Wang, *a Qingsheng Tao,c Yufei Li, d Hao Wang,a Mei Zhang,c Xueli Liuc and Jiaheng Zhang *a

a Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China. E-mail: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

b Shenzhen Shinehigh Innovation Technology Co., Ltd., Shenzhen 518055, China

c Advanced Research, L'Oreal Research & Innovation China, Shanghai 201206, China

d The Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao 999078, China

† Electronic supplementary information (ESI) available. CCDC 2101906. For ESI

and crystallographic data in CIF or other electronic format see DOI: https://doi.

org/10.1039/d5md00001g

Salicylic acid (SA) is a natural lipophilic active ingredient commonly used in cosmetics and skin disease treatments, offering benefits such as exfoliation, anti-inflammation effects, antibacterial properties, oil control, and acne alleviation. However, its poor water solubility, low bioavailability, and potential side effects, such as allergies, irritation, and dryness, hinder its widespread application. In this study, we prepared a betaine–salicylic acid (BeSA) cocrystal and systematically characterized its crystal structure, biological activity, and clinical efficacy. The results showed that BeSA has significantly lower irritancy and cytotoxicity than SA, but exhibits excellent anti-inflammatory and antioxidant properties as well as high moisturizing and anti-acne efficacy, making it a potential alternative to SA. Further, quantum chemical calculations and molecular docking simulations were conducted to investigate the intrinsic mechanisms underlying the excellent bioactivity of BeSA cocrystals. This study introduces an innovative solution for safer and more effective skincare formulations based on SA and offers theoretical guidance regarding material engineering and further material optimization, which has crucial implications for both industry and academia.

Received 1st January 2025,

Accepted 4th February 2025

DOI: 10.1039/d5md00001g rsc.li/medchem

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病足：疾病、并发症或症状？

负压创面疗法联合浸银敷料治疗混合伤口的临床经验：50 例个案的回顾性研究

中国慢性难愈性创面诊疗思路及原则

每2个糖尿病足患者就有一人要截肢，这是危言耸听么？

体检报告怎么看？九图带你读懂

伤口清创流程

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病足：疾病、并发症或症状？

负压创面疗法联合浸银敷料治疗混合伤口的临床 经验：50 例个案的回顾性研究

中国慢性难愈性创面诊疗思路及原则

每2个糖尿病足患者就有一人要截肢，这是危言耸听么？

体检报告怎么看？九图带你读懂

伤口清创流程

消息订阅

学术会议

伤口世界提示

负压创面疗法联合浸银敷料治疗混合伤口的临床经验：50 例个案的回顾性研究