Models and methods to support the development of novel burn wound antimicrobial treatments

ABSTRACT: Despite the advances in burn wound management, infection is a primary cause of morbidity, with infected burn wounds being responsible for 51% of burn related deaths. Because of the growing threat of multidrug resistant pathogens in burn injuries, novel therapeutic innovation remain important. This paper presents a comparison of common models and methods that support the development of novel burn wound antimicrobial treatments, of commonly available burn wound models 74% are performed in vivo, 23% are in vitro and just 3% use ex vivo tissue. The manufacturing of burn wound care products requires careful attention to materials, sterilisation, quality control, regulatory compliance and product design. By addressing these considerations systematically, manufacturers can successfully bring innovation solutions to the burn wound market while ensuring patient safety and product quality.

KEY WORDS

Antimicrobial

Biofilm

Burns

Ex vivo

In vitro

Models

Wounds

JENNIE RITCHIE

BA, ACIM, Marketing Executive, Perfectus Biomed Group, Now part of NAMSA, Techspace One SciTech Daresbury, Keckwick Lane, Daresbury, WA4 4AB, jennieritchie@perfectusbiomed. com

SAMANTHA WESTGATE, PhD, Scientific Director Microbiology and In Vitro Services, Perfectus Biomed Group, Now part of NAMSA, Techspace One SciTech Daresbury, Keckwick Lane, Daresbury, WA4 4AB, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

JIM POMONIS PhD, Associate Vice President, Scientific Affairs, NAMSA, 8945 Evergreen Blvd NW, Minneapolis, MN

Management of malignant fungating wounds with a bioactive microfibre gelling technology dressing: an evaluation

Aim: In this article, we aim to raise awareness of some of the clinical concerns surrounding the management of oncology wounds, particularly malignant fungating wounds. We will also provide practical wound management recommendations for healthcare professionals to consider when managing this wound type. We aim to assess the potential of a 100% chitosan with bioactive microfibre gelling (BMG™) dressing (MaxioCel®), to support wound management and work in partnership with industry to deliver clinical education on the management of oncology wounds, including malignant fungating wounds.

Method: A case study series was undertaken over four weeks, using the chitosan BMG dressing.

Results: We recruited 10 patients during the study. The chitosan BMG dressing facilitated a significant improvement in wound tissue type, exudate levels, and periwound skin, as well as reduced malodour. A reduction in patient-reported pain levels was also noted throughout the evaluation process. 

Conclusion: The introduction of BMG fibre technology demonstrated good outcomes in this patient group, in a short period of time. Importantly for this patient group, the BMG dressing was able to remain in situ during radiotherapy treatment, allowing uninterrupted management of the wounds.

KEY WORDS

Bioburden

Case studies

Malignant fungating wounds

Odour reduction

Oncology wounds

Pathways

SUSY PRAMOD

Lead Nurse Tissue Viability, The Christie NHS Foundation Trust, Manchester

SUE RICE

National Clinical Development Manager, CD Medical, Bolton, Lancashire

Engaging with and optimising care for people under age 50 years with type 2 diabetes: The DiaST model of care

Nicola Milne

Audit within Brooklands and Northenden Primary Care Network revealed that people with type 2 diabetes under the age of 50 years were an underserved population and were less likely to receive the recommended eight care processes than other age groups locally. This article outlines the initiatives carried out to address this inequality. The  work involved a Diabetes Support Team (DiaST) model of care and embedded an array of actions to overcome barriers to engagement among this hardly reached group. The initiative has resulted in more than a doubling of the rate of care process achievement in this population, although disparities with other age groups remain. The article should serve as inspiration for services looking to make the most of NHS England’s T2Day (Type 2 Diabetes in the Young) programme to fund extended health checks for people aged 18–39 years living with type 2 diabetes.

Citation: Milne N (2023) Engaging with and optimising care for people under age 50 years with type 2 diabetes: The DiaST model of care. Diabetes & Primary Care 25: [Early view publication]

Key words

– Audit

– DiaST

– Early-onset type 2 diabetes

– Service delivery

Author

Nicola Milne, DiaST Lead, Brooklands and Northenden PCN.

Closing the gap in acute lower limb care: a two-year review

Background: The management of leg ulceration through compression has predominately been considered a community care need. In 2021, Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust, in partnership with the Doncaster Wound Care Alliance, developed and launched a framework of interventions including education, a joint wound care formulary and clinical pathways, all aimed at standardising care. Additionally, they introduced the UrgoKTwo multicomponent compression system to provide seamless care across community, primary and secondary care using the National Wound Care Strategy Programme's (NWCSP) 2020 lower limb recommendations. As a result of changes implemented by the Skin Integrity Team at Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust,within secondary care, the knowledge of hospital staff increased by an average of 34% following attendance at structured education programmes, with 99% of staff being assessed as competent in the practical application of UrgoKTwo multicomponent compression bandage system. These improvements allowed the Skin Integrity Team to perform timely assessments, diagnoses and treatments for venous leg ulcers (VLUs), resulting in 89% of VLUs commencing UrgoKTwo multicomponent compression bandage system while patients were in the hospital and achieved healing within 12 months.

KEY WORDS

Education Healing rates Leg ulcers Lower limb UrgoKTwo

KELLY PHILLIPS Lead Nurse, Skin Integrity Team, Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust, FRAN MCNAB Skin Integrity Team, Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust.

KATIE PHILLIPS Acting Clinical Nurse Specialist, Skin Integrity Team, Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust.

TONI PLUMB Specialist Sister, Skin Integrity Team, Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust.

LOUISE WALL Specialist Sister, Skin Integrity Team, Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust.

VICTORIA DODD Specialist Sister, Skin Integrity Team, Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust.

GEMMA LONG Specialist Support Worker, Skin Integrity Team, Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust.

ENIKKA BARNES Specialist Support Worker, Skin Integrity Team, Doncaster and Bassetlaw Teaching Hospitals, NHS Foundation Trust.

深度烧伤创面削痂后植皮结合自体细胞再生技术治疗的临床研究

关键词：深度烧伤;临床研究;皮片移植

CGM for children and young people with type 1 diabetes: NICE criteria and effects of decision fatigue and alarm fatigue

Imogen Stamford

Research has shown that use of continuous glucose monitoring (CGM) is associated with improved time in range, improved HbA1c, and decreased risk of long-term complications secondary to type 1 diabetes. There are, however, several barriers that can lead to discontinuation of CGM, including pain, skin reactions, concerns around accuracy, sensor loss, interference with daily activity, and alarm fatigue. This review paper will outline the impact of decision fatigue and alarm fatigue in children and young people using CGM.

Citation: Stamford I (2022) CGM for children and young people with type 1 diabetes: NICE criteria and effects of decision fatigue and alarm fatigue. for Children & Young People Diabetes Care 12: [Early view publication]

Article points

1. While the advantages of continuous glucose monitoring (CGM) are well recognised, as practitioners it is important to be aware of the implications of CGM use.

2. People with diabetes can never have a day without checking and responding to ever-changing glucose levels, which puts them at an increased risk of developing decision fatigue.

3. It is important for practitioners to support patients in creating balance between setting alarm limits that are narrow enough to ensure patient safety, but not so narrow that alarms will be repeatedly triggered can lead to the risk of alarms being ignored.

Key words

- Alarm fatigue

- Continuous glucose monitoring

- Decision fatigue

- Type 1 diabetes

Author

Imogen Stamford, Paediatric Diabetes Specialist Nurse, Oxford University Hospitals NHS Foundation Trust