中国老年糖尿病诊疗指南（2024版）---1~4章

国家老年医学中心 中华医学会老年医学分会

中国老年保健协会糖尿病专业委员会

通信作者：郭立新，北京医院内分泌科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100730，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。；肖新华，中国医学科学院北京协和医学院

北京协和医院内分泌科，北京 100730，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

本指南由《中华糖尿病杂志》《中华老年医学杂志》和《Aging Medicine》于 2024年 2月同步发表

【摘要】　随着我国老龄化的加剧，老年糖尿病的患病率明显增高，其规范化管理对改善老年糖尿病患者的临床结局至关重要。2021年国家老年医学中心、中华医学会老年医学分会以及中国老年保健协会糖尿病专业委员会组织专家撰写了我国首部老年糖尿病指南，即《中国老年糖尿病诊疗指南（2021年版）》，强调老年糖尿病患者存在高度异质性，需要综合评估，采取分层和个体化的管理策略，首次提出针对老年糖尿病患者的“简约治疗理念”和“去强化治疗策略”。这版指南为临床医师提供了实用的、可操作的临床指导，对我国老年糖尿病患者全方位、全周期的规范化综合管理起到了极大的推动作用，同时也推动了我国老年糖尿病及相关领域的临床和基础研究的广泛开展。指南发布近三年来，国内外老年糖尿病及相关领域的循证医学证据进一步积累，新的治疗理念、新型药物及治疗技术不断涌现，指南编委会及时对第一版指南进行了更新，对老年糖尿病的血糖管理路径进行了进一步细化和优化，编写了《中国老年糖尿病诊疗指南（2024年版）》，以期继续助力中国老年糖尿病患者的规范化管理及临床结局的改善。

【关键词】　糖尿病；　老年人；　指南；　治疗路径

Guideline for the management of diabetes mellitus in the elderly in China (2024 edition)

National Center of Gerontology, Chinese Society of Geriatrics, Diabetes Professional Committee of Chinese Aging Well Association

Corresponding authors: Guo Lixin, Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China, Email: glx1218@163. com; Xiao Xinhua, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China, Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

目录

前言 ……………………………………………………… 148

编写说明 ………………………………………………… 148

第一章 老年糖尿病及其并发症的流行病学 ………… 149

第二章 老年糖尿病的诊断、分型及特点 …………… 149

第三章 老年糖尿病的三级预防 ……………………… 150

第四章 老年糖尿病患者的健康状态综合评估 ……… 150

第五章 老年糖尿病患者的健康教育 ………………… 151

第六章 老年糖尿病患者的血糖控制目标 …………… 152

第七章 老年糖尿病患者的生活方式干预 …………… 152

第八章 老年2型糖尿病患者的降糖药物及治疗路径……………………………………………… 154

第九章 老年糖尿病合并动脉粥样硬化性心血管疾病或危险因素的综合管理 ……………………… 159

第十章 老年糖尿病慢性并发症的筛查与处理 ……… 162

第十一章 老年糖尿病的急性并发症 ………………… 166

第十二章 老年糖尿病的共患疾病 …………………… 167

第十三章 老年糖尿病的多重用药 …………………… 171

第十四章 老年糖尿病的特殊情况 …………………… 172

第十五章 老年1型糖尿病及相关问题 ……………… 174

第十六章 糖尿病管理相关技术 ……………………… 174

第十七章 老年糖尿病与中医药学 …………………… 176

附录 ……………………………………………………… 177

糖尿病高危足患者自我管理临床实践指南和专家共识的 质量评价及内容分析

庄惠人¹  王文静²  俞海萍²  尤永梅¹  顾英杰¹  姚佳丽¹

¹ 同济大学附属东方医院伤口门诊，上海 201123；

² 同济大学附属东方医院护理部，上海 201123

通信作者：王文静，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

【摘要】 目的 检索糖尿病高危足患者自我管理临床实践的相关指南和专家共识，并对高质量指南和专家共识推荐意见的内容进行分析，为构建糖尿病高危足患者自我管理的指导方案提供借鉴。方法 计算机检索数据库、指南网和相关专业网站中的糖尿病高危足患者自我管理临床实践指南和专家共识，检索时限为2012至1月1日至2022年6月5日。由2名研究者对纳入文献进行质量评价,证据提取与整合，邀请专家对总结的证据进行评价。

结果  根据文献质量评价情况，共纳入12篇指南（A级10篇、B级2篇）和3篇专家共识（专家讨论决定），确定8个主题，分别为定期随访、自我评估、足部及减压管理、运动管理、营养管理、指标管理、心理管理、健康教育，共计28条推荐意见，其中A级推荐23条，B级推荐5条。

结论  本研究纳入指南和专家共识的质量较高，总结所得证据推荐等级亦较高，可为临床医护人员构建及指导糖尿病高危足患者自我管理临床实践提供参考及依据。

【关键词】 糖尿病足； 自我管理； 临床实践； 质量评价； 循证护理

基金项目：上海市护理学会2021年度学会级立项课题（2021MS-B08）；上海市浦东新区卫生健康委员会卫生科技项目（PW2021A-17）；同济大学医学院“护理学院（筹）学科建设三年行动计划”项目（JS2210328）

DOI：10.3760/cma.j.cn211501-20220822-02663

Quality evaluation and content analysis of clinical practice guidelines and expert consensus on self-management of patients with high-risk foot diabetes

Zhuang Huiren¹ , Wang Wenjing² , Yu Haiping² , You Yongmei¹ , Gu Yingjie¹ , Yao Jiali¹

¹ Department of Wound Clinic, Oriental Hospital Affiliated to Tongji University, Shanghai 201123, China;

² Department of Nursing, Oriental Hospital Affiliated to Tongji University, Shanghai 201123, China

Corresponding author: Wang Wenjing, Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

[Abstract]

Objective

To retrieve the relevant guidelines and expert consensus on selfmanagement of patients with high-risk foot diabetes, and analyze the content of high-quality guidelines and expert consensus recommendations, so as to provide a reference for the construction of a guidance program for self- management of patients with high- risk foot diabetes.

Methods

Computer- retrieved clinical practice guidelines and expert consensus for self-management of patients with high-risk foot for diabetes from databases, guideline networks, and related professional websites. The search period was from January 1, 2012 to June 5, 2022. The quality of the included literature was evaluated and the evidence was extracted and integrated by 2 researchers. Experts were invited to evaluate the summarized evidence.

Results

According to the quality of literature, a total of 12 guidelines (10 at level A and 2 at level B) and 3 expert consensus (expert discussion and decision) were included, and 8 themes were defined as regular follow- up, self- assessment, foot and decompression management, exercise management, nutrition management, indicator management, psychological management, and health education, a total of 28 recommendations. Among them, there were 23 A-level recommendations and 5 B-level recommendations.

Conclusions

The quality of the guidelines and expert consensus included in this study is high, the recommended level of the summarized evidence is high. This study provides the reference and basis for the clinical staff to construct and guide the clinical practice of self- management of high-risk diabetic foot

[Key words]

Diabetic foot; Self management; Clinical practice; Quality evaluation; Evidence-based nursing

Fund program: 2021 Academic Level Project of Shanghai Nursing Society (2021MS-B08); Shanghai Pudong New Area Health Commission Health Science and Technology Project (PW2021A- 17); Tongji University "Third Year Action Plan for Discipline Construction of School of Nursing" (JS2210328)

DOI：10.3760/cma.j.cn211501-20220822-02663

黄芪治疗黄褐斑的作用机制及应用概述

张静彦，郭 璇，段 渠

成都中医药大学附属医院，医学美容科，四川 成都

收稿日期：2023年9月8日；录用日期：2023年10月11日；发布日期：2023年10月23日

摘 要

黄芪作为中医常用的补气要药，在诸多损美性疾病中应用广泛，其对于治疗黄褐斑有着显著的疗效。现代药理学研究表明黄芪通过防护紫外线损伤、抗氧化、改善皮肤微循环等作用有效减少色素沉着。传统医学表明黄芪内服健脾补气、外用美白祛斑以达到治疗黄褐斑的作用。为进一步开发使用黄芪，文章对黄芪在黄褐斑中的应用及相关作用机制进行了综述。

关键词

黄芪，黄褐斑，色素增加性疾病，中医美容，中药应用

Overview of Mechanism and Application of Astragalus in Treating Melasma

Jingyan Zhang, Xuan Guo, Qu Duan

Department of Medical Cosmetology, Hospital of Chengdu University of Traditional Chinese Medicine,

Chengdu Sichuan

Received: Sep. 8 ^th, 2023; accepted: Oct. 11^th, 2023; published: Oct. 23 ^rd, 2023

Abstract

Astragalus is commonly used as an essential medicine for supplementing qi in Chinese medicine. It is widely used in many aesthetic diseases and has a remarkable effect on the treatment of melasma. Modern pharmacological studies have shown that astragalus effectively reduces pigmentation by protecting against ultraviolet damage, antioxidant, improving skin microcirculation and other effects. Traditional medicine shows that astragalus can achieve the effect of treating melasma by invigorating spleen, invigorating qi, whitening and removing freckles. In order to further develop the use of astragalus. This article reviewed the application of astragalus in melasma and the related mechanism of action.

文章引用: 张静彦, 郭璇, 段渠. 黄芪治疗黄褐斑的作用机制及应用概述[J]. 中医学, 2023, 12(10): 3055-3059.

DOI: 10.12677/tcm.2023.1210459

Keywords

Astragalus, Chloasma, Hyperpigmented Disorders, Traditional Chinese Medical Cosmetology, Application of Traditional Chinese Medicine

Copyright © 2023 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

国际糖尿病足工作组：指南的制定和方法学（２０２３） ———《国际糖尿病足工作组：糖尿病相关的足病预防与管理指南（２０２３） 》 的一部分）

Standards for the development and methodology of the 2023 International Working Group on the Diabetic Foot
Guidelines :Part of the 2023 IWGDF Guidelines on the prevention and management of diabetes-related foot desease

Sicco A. Bus^1,2 ，Matilde Monteiro-Soares^3.4.5, Fran Game', Jaap J. van Netten^1.2, Jan Apelqvist⁷ ，Robert Fitidge⁸ ,
Eric Sennville，Nicolaas C. Schaper0 ,on behalf of the IWGDF Editorial Board

1. Amsterdam UMC, University of Amsterdam, Department of Rehabilitation Medicine，Amsterdam, the Netherlands;

2.Amsterdam Movement Sciences，program Rehabilitation & Development , Amsterdam, the Netherlands;

3. Higher School of Health of the Portuguese Red Cross, Lisbon, Portugal;

4. Department of Community Medicine, Information and Health Decision Sciences ( MEDCIDS)，Faculty of Medicine, University of Porto, Porto, Portugal;

5. RISE@ CINTESIS, Faculty of Medicine, Oporto University, Porto, Portugal;

6. Department of Diabetes and Endocrinology ，University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK;

7. Department of Endocrinology, University Hospital of Malmo, Sweden;

8. Discipline of Surgery, The University of Adelaide and Vascular and Endovascular Service, Royal Adelaide Hospital, Australia;

9. Department of Infectious Diseases ，Gustave Dron Hospital, Tourcoing, France;

10. Division of Endocrinology, MUMC+，CARIM and CAPHRI Institute ，Maastricht, the Netherlands.

朱 虹１ 何 洁１ （译） 刘 芳２ （审校）

（ １ ． 温州医科大学附属第一医院内分泌科， 浙江 温州 ３２５０００；２ ． 上海交通大学医学院附属第一医院内分泌代谢科， 上海 ２０００８０）

【摘要】 糖尿病相关的足病是造成糖尿病患者经济负担和增加社会成本的主要原因之一。 本指南以主要目标为导向，以循证医学为依据，且在全球得到合理实施。 践行国际糖尿病相关的足病指南对于减轻患者经济负担和社会成本有着重要影响。

国际糖尿病足工作组（ＩＷＧＤＦ）从 １９９９ 年起开始发布并随后更新国际指南。 ２０２３ 年更新版指南相关推荐均基于推荐、评估、发展和评价分级（ＧＲＡＤＥ）系统，包括制定相关临床问题和重要结局，完成系统的文献系统综述和荟萃分析，完成评判表汇总，并且给予具体、明确、操作性强的推荐以及理论依据。

本文阐述了《国际糖尿病足工作组：糖尿病相关的足病预防和管理指南（２０２３ 版）》（以下简称为指南）的制定过程。指南由 ７ 个部分组成，包括预防、糖尿病相关的足溃疡分类、减压、周围动脉病变、感染、创面愈合干预以及活动性夏科神经骨关节病，分别由 ７ 个独立的国际专家工作组编写。 ＩＷＧＤＦ 编辑委员会对 ７ 个章节进行了整合和简化，形成 ＩＷＧＤＦ实践指南。 指南中的每条推荐均经过 ＩＷＧＤＦ 编辑委员会成员和相关领域的独立的国际专家审阅通过。 本文是 ＩＷＧＤＦ指南的制定和方法学。

我们相信，医务人员、公共卫生机构和政策制定者采用和实施 ２０２３ 年 ＩＷＧＤＦ 指南，将会改善糖尿病相关的足病的预防和管理水平，从而减少全球该疾病患者和减轻该疾病引起的全球社会负担。

【关键词】 指南； 糖尿病； 糖尿病相关的足病； 方法学； 国际糖尿病足工作组

ｗｗｗ．ｉｗｇｄｆｇｕｉｄｅｌｉｎｅｓ．ｏｒｇ

中图分类号：Ｒ５８７．２；Ｒ－０１

文献标识码：Ｃ

A new framework for the diagnosis, staging and management of obesity in adults

Luca Busetto, Dror Dicker, Gema Frühbeck, Jason C. G. Halford, Paolo Sbraccia, Volkan Yumuk & Gijs H. Goossens

      The European Association for the Study of Obesity presents a new framework for the diagnosis, staging and management of obesity in adults to better align with the concept of obesity as an adiposity-based chronic disease.

      Obesity is a multifactorial, chronic, relapsing, non-communicable disease marked by an abnormal and/or excessive accumulation of body fat that presents a risk to health. It is well established that obesity acts as a gateway to a range of other non-communicable and communicable diseases^1–3 .

      Despite this wide recognition of obesity as a chronic disease, the clinical recommendations that guide the diagnosis of obesity and its management have not been aligned sufficiently with the clinical processes normally adopted for other chronic diseases. In many settings, the diagnosis of obesity is still based solely on body mass index (BMI) cut-off values, and does not reflect the role of adipose tissue distribution and function in the severity of the disease1 . Moreover, the indications for using the different therapeutic approaches now available for obesity management remain mostly based on anthropometric measurements, rather than on a more complete clinical evaluation of the individual4 . This is in sharp contrast with other chronic diseases, for which clear therapeutic indications are described, targets are set, and the choice of the type and intensity of treatment is based on the probability of reaching the treatment target, with adequate and prompt treatment intensification when the target is not reached.

     To stimulate the development and implementation of clinical guidelines for obesity that are more aligned with those already in place for other chronic diseases, the European Association for the Study of Obesity (EASO) initiated and conducted a consensus process to propose a new framework for the diagnosis, staging and management of obesity in adults.

Consensus process

      We performed a modified Delphi study5,6 to identify a set of statements that can aid in the diagnosis, staging and management of obesity according to a framework that is more adherent to the concept of obesity as an adiposity-based chronic disease (ABCD)1 . A steering committee identified by the EASO, consisting of the authors of this paper, discussed and prepared an initial set of statements used for a voting process by a group of experts. Voting was performed on a five-point scale, as follows: (1) strongly disagree; (2) disagree; (3) neither agree nor disagree; (4) agree; and (5) strongly agree. In each round of voting, experts were also asked to provide comments to explain their voting score, and responses were anonymized. The steering committee evaluated the voting and comments received at each  round and generated a modified set of statements for the subsequent round of voting. Consensus was defined as ≥75% of expert agreement on a statement (score ≥4).

     The steering committee retained responsibility for the selection of experts involved in the process. Selection was based on international reputation and known expertise in obesity science and management.

     In total, 29 experts were contacted, and all agreed to participate in the present study. Most of the experts belong to the endocrinology, nutrition or internal medicine fields (72%), but the group also included five bariatric surgeons, two primary care physicians and one expert on patient advocacy. A standard conflict of interest form was completed by each participant before the start of the Delphi process. This study was performed by the EASO without any external funding, and approval by the ethics committee was not required.

      The study comprised three Delphi rounds. In the first round, 25 experts (86%) voted and commented on 30 original statements that were prepared by the steering committee. A total of 21 statements (70%) received consensus. The steering committee evaluated voting and comments and generated a second set of 28 statements submitted for a second Delphi round. In the second round, 24 experts (83%) voted and commented on the statements. A total of 24 statements (86%) received consensus. The steering committee discussed the comments received for the four non-consented statements, reconsidered the formulations of these statements, and submitted the four revised statements for the final Delphi round. In the third round, 24 experts (83%) voted and provided final comments related to the four revised statements. One of these four statements (statement 12) reached full consensus, whereas most experts approved the other three revised statements (statements 3–5), with only a few experts providing a score <3 (that is, strongly disagree or disagree). The steering committee performed a final revision and decided to approve a list of 28 statements, covering clinical diagnosis and staging of obesity, pillars of treatment, therapeutic targets, and initial level of intervention. The final list of statements and final percentages of approval by the experts is shown in Table 1. A flowchart of the diagnostic and therapeutic pathways resulting from the statements is presented in Fig. 1.

A chronic progressive disease

      The recognition of obesity as a complex chronic non-communicable disease should inform the development of evidence-based guidelines for the diagnosis and management of obesity. We anticipate that, in conjunction with other ongoing initiatives⁷ , this Delphi process will contribute to improving obesity management in adults living with obesity.

      Based on current clinical evidence, the diagnosis of obesity should not be based solely on the presence of an abnormal and/or excessive fat accumulation (anthropometric component). The diagnosis of obesity should instead include a careful analysis of the present and potential effects that dysfunctional and/or excessive fat accumulation may have on health (clinical component) (statement 1). This statement aligns with what has been suggested by other recent guidelines on obesity management^8,9 . Moreover, this statement fully adheres to the concept that obesity should be considered a chronic progressive disease process that may transit from a relatively asymptomatic state to a phase in which abnormal and/or excessive fat accumulation is accompanied by health impairments, and finally to a life-threatening or disabling condition¹⁰.

Abdominal fat accumulation

      An important novelty of our framework regards the anthropometric component of the diagnosis. The basis for this change is the recognition that BMI alone is insufficient as a diagnostic criterion, and that body fat distribution has a substantial effect on health. More specifically, the accumulation of abdominal fat is associated with an increased risk of developing cardiometabolic complications and is a stronger determinant of disease development than BMI, even in individuals with a BMI level below the standard cut-off values for obesity diagnosis¹¹. This is reflected by two important statements. First, we make explicit that abdominal (visceral) fat accumulation is an important risk factor for health deterioration, also in people with low BMI and still free of overt clinical manifestations (statement 3). Second, the new framework includes people with lower BMI (≥25–30kg/m2 ) but increased abdominal fat accumulation and the presence of any medical, functional or psychological impairments of complications in the definition of obesity, hence reducing the risk of undertreatment in this particular group of patients in comparison to the current BMI-based definition of obesity (statement 4). The choice of introducing waist-to-height ratio, instead of waist circumference, in the diagnostic process is due to its superiority as a cardiometabolic disease risk marker¹².

Diagnostics and staging

      The clinical component of the diagnosis should include a systematic evaluation of medical, functional and psychological (such as mental health and eating behavior pathology) impairments in any person with obesity, as also suggested in other guidelines^8,9 . A detailed description of the clinical aspects and methodologies that need to be included in this systemic clinical evaluation was beyond the scope of this exercise. For the medical evaluation (statement 9), several documents are available to provide guidance^4,8 . For the functional and psychological evaluation, examination may be performed using an array of methods, ranging from easy-to-perform tests that are applicable in the primary care setting to more sophisticated tests, which may be reserved for specialized centers (statements 10 and 13). Considering the emerging problem of obesity in older individuals, statement 11 was included to emphasize the importance of performing a diagnostic assessment (muscle strength, performance and body composition) for sarcopenic obesity¹³. Finally, considering the strong association between obesity and several types of cancer, a statement calling for regular screening for obesity-related cancers in any person with obesity was included (statement 12).

      Clinical staging processes are frequently used to evaluate and describe an individual’s health status and the progression of chronic diseases. Clinical staging usually expresses the severity of a disease in a simplified, condensed and standardized way. This has prognostic implications, and it may guide or mandate therapeutic interventions. In our Delphi process, the experts agreed on the importance of staging obesity as a chronic, relapsing disease, according to the severity of its clinical manifestations and complications (statement 14), as proposed by previous guidelines⁹ .

Obesity management

      Considering the pillars of treatment of people with obesity (statements 15–21), our recommendations substantially adhere to current available guidelines^4,8,9 . Behavioral modifications, including nutritional therapy, physical activity, stress reduction and sleep improvement, were agreed as main cornerstones of obesity management, with the possible addition of psychological therapy, obesity medications and metabolic or bariatric (surgical and endoscopic) procedures. For the latter two options, the steering committee discussed the fact that current guidelines are based on clinical evidence derived from clinical trials, in which inclusion criteria were mostly based on anthropometric cut-off values rather than on a complete clinical evaluation4,8,9,14. In current practice, the strict application of these evidence-based criteria precludes the use of obesity medications or metabolic/bariatric procedures in patients with a substantial burden of obesity disease, but low BMI values. Therefore, members of the steering committee proposed, and experts subsequently agreed (79%), that, in particular, the use of obesity medications should be considered in patients with BMI ≥ 25 kg/m2 and a waist-to-height ratio > 0.5 and the presence of medical, functional or psychological impairments or complications, independently from current BMI cut-off values (statement 18). This statement may also be seen as a call to pharmacological companies and regulatory authorities to use inclusion criteria that are more adherent to the clinical staging of obesity and less to traditional BMI cut-offs when designing future clinical trials with obesity medications15.

      Full agreement among the experts was reached for the statement that the management of obesity should move beyond weight loss alone, and should include the prevention, resolution or improvement of obesity-related complications, a better quality of life and mental wellbeing, and improvement of physical and social functioning and fitness (statement 22). This statement will move obesity management closer to the management of other non-communicable chronic diseases, in which the goal is not represented by short-term intermediate outcomes, but by long-term health benefits. Defining long-term personalized therapeutic goals should inform the discussion with the patients from the beginning of the treatment, considering the stage and severity of the disease, the available therapeutic options and possible concomitant side effects and risks, patient preferences, individual drivers of obesity and possible barriers to treatment (statements 23 and 24). Emphasis on the need for a long-term or life-long comprehensive treatment plan rather than short-term body weight reduction is warranted.

      The concept of obesity as a chronic disease and the discussion of therapeutic targets should also inform the choice of the initial level of intervention and eventual intensification of therapy (statements 26–28), avoiding the same repetitive and futile cycles of intervention that are not effective enough to achieve patient benefit, and preventing therapeutic inertia¹⁶.

      This Delphi process represents the current vision of the EASO on the diagnosis, staging and management of obesity as a complex, relapsing, non-communicable chronic disease in adults. We anticipate that the recommendations outlined in this paper, in conjunction with other ongoing international initiatives7 , will contribute to improved obesity management strategies that are more consistent with treatment algorithms already applied for other non-communicable chronic diseases. Moreover, this framework may aid scientific advancements and the development of new clinical practice guidelines.

Luca Busetto1 , Dror Dicker2 , Gema Frühbeck  3 , Jason C. G. Halford4 , Paolo Sbraccia5 , Volkan Yumuk6 & Gijs H. Goossens  7

¹ Department of Medicine, University of Padova, Padova, Italy.

² Internal Medicine Department and Obesity Clinic, Hasharon Hospital-Rabin Medical Center, Petach-Tikva, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

³ Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, CIBEROBN, IdiSNA, Pamplona, Spain.

⁴ School of Psychology, University of Leeds, Leeds,UK. 

⁵ Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

⁶ Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

⁷ Department of Human Biology, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center⁺, Maastricht, The Netherlands.

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Published online: 05 July 2024

References
1. Fruhbeck, G. et al Obes. Facts12, 131-136 (2019).

2. Dicker, D. et al. Obes. Facts 13, 430- -438 (2020).

3. Burki, T. Lancet Diabetes Endocrinol.9, 418 (2021).

4. Yumuk, V. et aL Obes. Facts 8, 402- -424 (2015).

5. Clayton, M. J. Educ. Psychol. 17, 373- -386 (1997).

6. Hasson, F., Keeney, S. & McKenna, H. J. Adv. Nurs.32, 1008- 1015 (2000).

7. Rubino, F. et aL Lancet Diabetes EndocrinoLl. 11, 226- 228 (2023).

8. Garvey, W. T. et al Endocr. Pract. 22, 1-203 (2016).

9. Wharton, S. et aL CMAJ192, E875-E891 (2020).

10. Bray, G. A.,. Kim, K. K., Wilding, J P. H. & on behalf of World Obesity Federation. Obes. Rev. 18, 715-723 (2017).

11. Goossens, G. H. Obes. Facts 10, 207 -215 (2017).

12. Ashwell, M.. Gunn, P. & Gibson, S. Obes. Rev. 13, 275- -286 (2012).

13. Donini, L. M. et al. Obes. Facts.15, 321-335 (2022).

14. Di Lorenzo, N. et al Surg. Endosc.34, 2332- -2358 (2020).

15. Agarwal, A. A., Narayan, A. & Stanford, F. C. JAMA Intern. Med. 184, 341-342 (2024).

16. Busetto, L, Sbraccia, P. & Vettor, R. Eat Weight Disord. 27, 761-768 (2022).

List of experts

The Steering Commitee identifed by EASO for this project, consisting of the authors of this paper, takes full responsibility for the contents of this Comment. The below specialists participated in the voting process of the Delphi methodology, but not in interpretation of the results or writing of the Comment, and agreed to be mentioned here: M. Agarwal, R. Barazzoni, T. Comuzzie, M. De Luca, N. Di Lorenzo, D. Durrer-Schutz, T. Garvey, C. Hughes, L. Kaplan, C. LeRoux, J. Mechanick, N. Montano, Jean-M. Oppert, R. Peterli, K. Pietilainen, G. Prager, X. Ramos-Salas, D. Ryan, M. Ryden, A. Sharma, and E. van Rossum.

Competing interests
L.B. received personal funding from Novo Nordisk, Boehringer Ingetheim, Eli Lilly, Pfizer, Bruno Farmaceutici as a member of advisory boards, and from Rythms Pharmaceuticals and Pronokal as a speaker. D.D. received personal funding from Novo Nordisk, Boehringer Ingelheim, Eli Lilly as a member of advisory boards, and from Novo Nordisk, Boehringer Ingelheim, Eli Lilly as a speaker. G.F. received payment of honoraria from Lilly and Novo Nordisk as a member of advisory boards, and payment of honoraria for lectures as member of the OPEN Spain Initiative. The University of Leeds received funding from Novo Nordisk for J.C.G.H.s participation in the ACTION-Teens study. PS. received payment of honoraria and consulting fees from Novo Nordisk, Eli Lly, Pfizer, Boehringer Ingelheim and Bruno
Farmaceutici as a member of advisory boards. V.Y. received personal funding from Novo Nordisk and Eli Lilly as a member of advisory boards and from Novo Nordisk as a speaker. G.H.G. received research funding from the European Foundation for the Study of Diabetes, the Dutch Diabetes Research Foundation and the Dutch Research Council (NWO).

This article is excerpted from the naturemedicine by Wound world.

女性雄激素性脱发诊断与治疗中国专家 共识（２０２２ 版）

中华医学会整形外科学分会女性雄激素性脱发诊断与治疗专家共识编写组 中国女医师协会整形美容专业委员会

通信作者：张菊芳，浙江大学医学院附属杭州市第一人民医院医学美容科，杭州

３１０００６，Ｅｍａｉｌ： ｚｈｊｕｆ＠ ｖｉｐ．ｓｉｎａ． ｃｏｍ；吴文育，复旦大学附属华山医院皮肤科，上海２０００４０，Ｅｍａｉｌ： ｗｕｗｅｎｙｕ＠ ｈｕａｓｈａｎ．ｏｒｇ．ｃｎ

【摘要】 女性雄激素性脱发与男性雄激素性脱发在病因、诊断、治疗等方面均有所不同，但目前国内外缺乏针对女性雄激素性脱发的诊断与治疗共识。 为了统一女性雄激素性脱发诊断及治疗标准，我国多个学术组织的专家共同启动了女性雄激素性脱发诊断与治疗专家共识的制定。 该共识包括女性雄激素性脱发的命名、流行病学、发病机制、临床表现、诊断依据及鉴别诊断要点、脱发分级、诊断流程、治疗方法。 基于相关循证医学证据，将共识编写组专家意见汇总，形成推荐意见，为临床医生提供参考。

【关键词】 脱发； 女性雄激素性脱发； 诊断； 治疗； 专家共识

基金项目： 国家自然科学基金 （ ８２１７３４４２， ８２１０３７５９）； 上海毛发医学工程技术研究中心（１９ＤＺ２２５０５００）；上海申康医院发展中心临床三年行动计划（ ＳＨＤＣ２０２０ＣＲ２０３３Ｂ）；上海市科学技术委员会西医引导类项目（１９４１１９６２４００）；杭州市医学重点学科（ＯＯ２０２０００４４）

ＤＯＩ：１０