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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

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广东省内运动医学专业唯一的博士研究生导师

美国哈弗大学医学院骨科访问学者

专业特长处于省内领先、国内或国际先进水平以上

2018年获得“国之名医卓越建树”荣誉称号

2017年被评为全国卫生计生系统先进工作者、广东省医学领军人才

中国医师协会运动医师分会副会长

STCOT中国部运动医学分会副主任委员

广东省医学会关节外科分会主任委员

广东省医学会运动医学会分会名誉主任委员

独立承担过国家“863”课题，主持过10余项省、部级科研项目

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Radiofrequency Treatment Attenuates Age-Related Changes in Dermal–Epidermal Junctions of Animal Skin 2024-12-25 00:00

Kyung-A Byun 1,2,3,†, Hyoung Moon Kim 4,† , Seyeon Oh 3 , Sosorburam Batsukh 1,3, Kuk Hui Son 5,* and Kyunghee Byun 1,3,6,*

1 Department of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea

2 LIBON Inc., Incheon 22006, Republic of Korea

3 Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea

4 Maylin Anti-Aging Center Ilsan, Goyang 10391, Republic of Korea

5 Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University, Incheon 21565, Republic of Korea

6 Department of Health Sciences and Technology, Gachon Advanced Institute for Health & Sciences and Technology (GAIHST), Gachon University, Incheon 21999, Republic of Korea

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.H.S.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.B.); Tel.: +82-32-460-3666 (K.H.S.); +82-32-899-6511 (K.B.)

† These authors contributed equally to this work.

Abstract: The dermal–epidermal junction (DEJ) is essential for maintaining skin structural integrity and regulating cell survival and proliferation. Thus, DEJ rejuvenation is key for skin revitalization, particularly in age-related DEJ deterioration. Radiofrequency (RF) treatment, known for its ability to enhance collagen fiber production through thermal mechanisms and increase heat shock protein (HSP) expression, has emerged as a promising method for skin rejuvenation. Additionally, RF activates Piezo1, an ion channel implicated in macrophage polarization toward an M2 phenotype and enhanced TGF-β production. This study investigated the impact of RF treatment on HSP47 and HSP90 expression, known stimulators of DEJ protein expression. Furthermore, using in vitro and aged animal skin models, we assessed whether RF-induced Piezo1 activation and the subsequent M2 polarization could counter age-related DEJ changes. The RF treatment of H2O2 -induced senescent keratinocytes upregulated the expression of HSP47, HSP90, TGF-β, and DEJ proteins, including collagen XVII. Similarly, the RF treatment of senescent macrophages increased Piezo1 and CD206 (M2 marker) expression. Conditioned media from RF-treated senescent macrophages enhanced the expression of TGF-β and DEJ proteins, such as nidogen and collagen IV, in senescent fibroblasts. In aged animal skin, RF treatment increased the expression of HSP47, HSP90, Piezo1, markers associated with M2 polarization, IL-10, and TGF-β. Additionally, RF treatment enhanced DEJ protein expression. Moreover, RF reduced lamina densa replication, disrupted lesions, promoted hemidesmosome formation, and increased epidermal thickness. Overall, RF treatment effectively enhanced DEJ protein expression and mitigated age-related DEJ structural changes by increasing HSP levels and activating Piezo1.

Keywords: aged mice skin; bipolar; dermal–epidermal junction; heat shock protein; monopolar; Piezo1; radiofrequency

Citation: Byun, K.-A.; Kim, H.M.; Oh, S.; Batsukh, S.; Son, K.H.; Byun, K. Radiofrequency Treatment Attenuates Age-Related Changes in Dermal–Epidermal Junctions of Animal Skin. Int. J. Mol. Sci. 2024, 25, 5178. https://doi.org/10.3390/ ijms25105178

Academic Editor: Terrence Piva

Received: 16 April 2024

Revised: 3 May 2024

Accepted: 7 May 2024

Published: 9 May 2024

Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Epidermal stem cells: skin surveillance and clinical perspective 2024-12-24 00:00

Xin Tang1†, Jiaqi Wang1†, Jiaoling Chen1†, Wanting Liu1 , Pei Qiao1 , Huiyi Quan1 , Zhiguo Li1 , Erle Dang1 , Gang Wang1* and Shuai Shao1*

Abstract

The skin epidermis is continually infuenced by a myriad of internal and external elements. At its basal layer reside epidermal stem cells, which fuels epidermal renovation and hair regeneration with powerful self-renewal ability, as well as keeping diverse signals that direct their activity under surveillance with quick response. The importance of epidermal stem cells in wound healing and immune-related skin conditions has been increasingly recognized, and their potential for clinical applications is attracting attention. In this review, we delve into recent advancements and the various physiological and psychological factors that govern distinct epidermal stem cell populations, including psychological stress, mechanical forces, chronic aging, and circadian rhythm, as well as providing an overview of current methodological approaches. Furthermore, we discuss the pathogenic role of epidermal stem cells in immune-related skin disorders and their potential clinical applications.

Keywords Epidermal stem cells, Aging, Wound healing, Immune-related skin disorders, Regeneration

† Xin Tang, Jiaqi Wang and Jiaoling Chen contributed equally to this work.

*Correspondence:

Gang Wang

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Shuai Shao

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1 Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shannxi, China

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modifed the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
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伤口管理

伤口世界，是倡导远程、就近和居家管理慢性伤口的连接、整合和拓展线上和线下资源的平台生态圈。解决了伤口专家碎片化时间的价值创造、诊疗经验的裂变复制，和患者的就近、居家、低成本管理慢性伤口的问题。

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自成立以来，教育一直是伤口世界的主要关注领域之一。改善伤口管理和伤口护理教育是实现协会改善和发展伤口管理的主要目标的重要因素。教育活动由教育委员会协调。协会教育培训活动案例...

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慢性伤口给患者带来无尽的痛苦：疼痛为普遍症状，有时痛不欲生；活动受限；误工；失业；经济压力；护理的沉重负担；长期不愈合和反复治理无效，导致怨恨治疗；对生活的的消极反应：家庭矛盾、社交恐惧、孤独、抑郁、焦虑、自我否定、自杀倾向。

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裴剑浩

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擅长治疗糖尿病、糖尿病足等疾病。发表专业论文20多篇,参与各项研究课题10多项,尤其擅长自身免疫性糖尿病的研究。广东省医疗行业协会伤口管理分会主任委员，广东省医学会糖尿病分会副主任委员。广东省人民医院内分泌科主任医师、教授。

李孝建

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专长：重症烧伤救治。广东省医学会烧伤科分会主任委员、广东省医疗行业协会伤口管理分会副主委。广东红十字会医院烧伤整形科主任医师，博士研究生导师。烧伤科大主任、烧伤ICU主任。

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擅长：烧伤后期整形、各种顽固性创面如各种压力性溃疡、糖尿病足等治疗、危重烧伤救治、烧伤内脏并发症的防治、各种外伤后疤痕畸形的修复重建。发表论文40余篇。主任医师、教授，南方医院烧伤外科主任，医学博士，博士研究生导师。学术任职：广东省医师协会烧伤科医师分会副主任委员，广东省医疗行业协会伤口管理分会副主委。

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从事内分泌代谢专业30余年, 对甲亢、糖尿病、肾上腺疾病等诊治有较丰富的临床经验.在糖尿病足的防治和减少糖尿病截肢率方面富有经验。

杨川

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内分泌代谢学博士。教授、主任医师、博士生导师。主要的工作学习经历： 2001年7月中南大学内分泌研究所博士研究生毕业，获博士学位；2001年8月到2003年7月中山大学孙逸仙纪念医院从事博士后研究工作。

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南方医科大学第三附属医院副主任医师硕士导师医学博士采用无痛非手术疗法诊治各种原因导致的皮肤溃烂，如糖尿病足溃疡、压疮、下肢血管性溃疡、外伤后伤口不愈、手术后切口不愈、痛风、骨髓炎等。

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感染伤口的微生物学评估

伤口世界, 2021-07-12 00:00

识别和管理伤口感染是一线医疗实践的重要任务。然而，有关伤口感染病因和采样的很多问题仍然存有争议，缺乏共识。很多伤口感染能够得到临床诊断，而实验室检查的结果提供进一步信息来指导治疗。只有当伤口存在临床感染表现和伤口在恶化、增大或不能愈合时才有必要进行(拭子)培养。对没有感染的伤口进行拭子采集会产生不必要的微生物识别和分析，而所发现的微生物可能仅定植于伤口,而非引起感染。 ...

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慢性伤口治疗中普遍存在的问题？

伤口世界, 2019-10-12 00:00

原创：卢魁慢性伤口治疗中普遍是什么问题困扰着患者呢？问题一：悲观思想，认为患了不治之症 ...

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EMPIRICAL STUDIES The International Consolidated Venous Ulcer Guideline Update 2015: Process ...

伤口世界, 2019-11-19 00:00

Authors Kara S. Couch CWS; Lisa Corbett CWOCN; Lisa Gould Susan Girolami Laura Bolton Keywords validation studies practice guideline Venous Ulcer Interdisciplinary Evidence-Based ...

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Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process

伤口世界, 2022-01-07 00:00

Abstract: Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and fifinally culminating with the formation of a fifibrin clot. However, delay in ...

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EMPIRICAL STUDIES Sequential Organ Failure Assessment (SOFA) to Predict Pressure Ulcer Risk in ...

伤口世界, 2019-11-15 00:00

Authors Maarit Ahtiala Esa Soppi Teijo I. Saari Keywords retrospective cohort study Pressure Ulcer intensive care Risk Assessment SOFA scale Jackson/Cubbin risk scale Issue: Volume 64 ...

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EMPIRICAL STUDIES A Retrospective Analysis to Evaluate Seasonal Pressure Injury Incidence ...

伤口世界, 2019-11-20 00:00

Authors Hong-Lin Chen Bin Zhu Rong Wei Zhen-Yu Zhou Keywords retrospective study pressure injury seasonal variation hip fractures elderly Issue: Volume 64 - Issue 2 - February 2018 ...

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

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